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  • 1995-1999  (9)
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Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 109 (1998), S. 2361-2370 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A simple yet reasonably accurate perturbation theory for the Gay–Berne model, capable of describing the uniform isotropic and nematic phases, as well as the layered smectic-A phase, is presented. The theory, in line with a previously proposed theory, is based on a perturbative scheme, but the reference system, a hard Gaussian overlap model, is treated using the nonlocal approximation of Somoza and Tarazona. This approximate scheme, which reduces to the well-known decoupling approximation for nematics, is a simple generalization of the decoupling approximation designed to include smectic structures. The attractive free energy is calculated using a mean-field approximation. Underestimation of the attractive energy implied by this approximation is alleviated by introducing some scale factors, set to reproduce the critical point and two triple points involving the smectic phase. The choice of scale factors, which is valid for a particular set of molecular parameters, is shown to reproduce accurately the phase diagram corresponding to other parameter values. The theory is used to examine the global liquid-crystalline phase behavior of the Gay–Berne model, paying particular attention to the effect of the anisotropy attraction parameter κ′ on the location of the various phase boundaries. Comparison of the results with the available computer simulations for this system indicates that the theory leads to qualitatively correct predictions. The theory could be useful to predict the phase behavior of realistic systems with respect to molecular elongation and energy anisotropy. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 102 (1995), S. 8107-8113 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A thermodynamic linear perturbation theory for the Gay–Berne intermolecular potential has been developed which is able to predict the occurrence of isotropic liquid-vapour coexistence as well as the stability of a nematic phase. The theory can be regarded as a generalisation to molecular fluids of the Weeks, Chandler, Andersen (WCA) pertubative scheme for simple fluids. The reference system, a hard Gaussian overlap model, is analysed within density-functional theory using a standard Onsager-like approach, the "decoupling approximation,'' where density correlations are treated to all orders (albeit approximately) whereas orientational correlations are approximated by the low density limit. We implement this idea by using an equivalent system of hard spheres to approximate the density-dependent part of the excess free energy. The structure of the reference system is approximated by the radial distribution function of an equivalent system of hard spheres, scaled with the contact distance of the hard core. The phase diagram for the Gay–Berne fluid obtained from the theory is compared with computer simulation data of the same model potential and found to be in fair agreement. In contrast, a mean-field approximation for the perturbative term gives rather poor results. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 102 (1995), S. 1098-1099 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: In this note we present molecular dynamics (MD) simulation results of the melting transition of a hexane monolayer adsorbed on graphite. The present study was motivated by the recent simulation results of the same system by Hansen et al. [J. Chem. Phys. 98, 4128 (1993)]. Using a United Atom model for the representation of the inter- and intramolecular interactions, and the standard Steele expression for the monolayer-substrate potential, the latter authors obtained a melting temperature for the monolayer-substrate potential, the latter authors obtained a melting temperature for the monolayer which is at odds with experiment by 25%. In contrast, we show that when Steele's method to model adsorbate–substrate interactions, based on Lorentz–Berthelot's rule, is used, the transition temperature is in good agreement with experiment. The weaker surface potential also causes a slight increase in the width of the tilt distribution of the molecular axes and a decrease in the number of gauche defects. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford BSL : Blackwell Science Ltd
    British journal of dermatology 140 (1999), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: HIV-associated pityriasis rubra pilaris (PRP) or PRP type VI designates a new distinctive entity reported in HIV patients. It is characterized by cutaneous lesions of PRP and variable association with lesions of acne conglobata, hidradenitis suppurativa and lichen spinulosus. We report a patient with HIV-associated PRP which was treated by triple antiretroviral therapy (zidovudine, lamivudin and saquinavir) with complete response. The patient has remained free from symptoms for 20 months of follow-up. We review the clinical features, pathology, evolution, treatment and possible aetiology of this recently described entity.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract It is established that phenytoin, cyclosporin and some calcium antagonists produce gingival overgrowth, but it is not known how this condition may respond to causal periodontal treatment. In order to find out, a longitudinal study was carried out, over a year, comparing a group of patients who were given nifedipine (NG, n= 18) and another group who were given diltiazem (DG. n= 13) with 2 others: one comprised cardiopathic patients who took no calcium antagonists (CG, n= 12) and the other contained patients who were medically healthy. with moderate periodontitis (HG, n= 12). On their basal visit, they were examined and instructed in oral hygiene, and then given causal periodontal treatment, being seen again at 4 and 8 months, when hygiene instructions were reinforced. They were seen for the last time at 12 months, when they were again examined. Groups NG and DG, on their basal visit, showed larger gum size than groups HG and CG. which was statistically significant; on their final visit, these differences remained only at the interproximal level. The number of patients with gingival overgrowth-taking the average of group HG as a minimal value-was much higher in groups CG (92%). DG (100%) and NG (89%) on the basal visit; on the final visit, the differences remained only in groups DG (85%) and NG (83%). The probing pocket depth reduction was much greater in groups HG and CG than in DG and NG. basically due to a greater gaining on clinical attachment level. The % of sites in which the pocket depth improved by more than 2 mm was 39.8% in HG, 54.5% in CG, 23.7% in DG and 28.7% in NG. The % of sites where the attachment gain by more than 2 mm was 46.2% in HG, 55.5% in CG, 22.8% in DG and 21.4% in NG. The amount of plaque and bleeding on probing, which was similar in all groups on the basal visit, decreased throughout the study, especially between the basal and 2nd visit in groups HG and CG. We have demonstrated that patients that take nifedipine and diltiazem show a larger gum size and their response to causal periodontal treatment is poorer than in the healthy and the cardiac groups.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 17 (1998), S. 587-590 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A hospital-based matched case-control study was conducted in order to identify risk factors for the development of bloodstream infections in adult hospitalized patients. Between January 1993 and December 1994, 264 episodes of bloodstream infection were evaluated. Significant variables identified by univariate analysis were included in a multivariate model that showed that central venous catheter [odds ratio (OR), 6.71], poor performance status (OR, 3.40), weight loss (OR, 2.47), hematologic diseases (OR, 2.24), and previous antimicrobial therapy (OR, 2.12) independently influenced the outcome. The knowledge of modifiable risk factors is useful in the development of strategies that may contribute to the prevention of bloodstream infections.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 17 (1998), S. 587-590 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A hospital-based matched case-control study was conducted in order to identify risk factors for the development of bloodstream infections in adult hospitalized patients. Between January 1993 and December 1994, 264 episodes of bloodstream infection were evaluated. Significant variables identified by univariate analysis were included in a multivariate model that showed that central venous catheter [odds ratio (OR), 6.71], poor performance status (OR, 3.40), weight loss (OR, 2.47), hematologic diseases (OR, 2.24), and previous antimicrobial therapy (OR, 2.12) independently influenced the outcome. The knowledge of modifiable risk factors is useful in the development of strategies that may contribute to the prevention of bloodstream infections.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder. To date, a relatively small number of NF1 mutations have been characterized, thus precluding genotype-phenotype correlations. By genotyping 75 NF1 families, we have detected six hemizygous patients (two of whom are members of the same family). The five presumed deletions were confirmed by two quantitative methods of analysis of NF1 copy number: Southern hybridization with cDNA probes and a single-strand conformation polymorphism analysis that discriminates between the NF1 gene and the pseudogene sequences. The five deletions remove most of the NF1 gene, at least 225 kb, from exon 9 to the 3′ end of the coding sequence. The origin of de novo mutations in the NF1 gene has been reported to be mainly paternal but we have determined that four of the de novo deletions involved the maternal chromosome and one the paternal chromosome. The six patients with deletions exhibited precocious, multiple clinical features of the disease. The incidence of tumor complications, particularly plexiform neurofibromas and intracranial tumors, among this group of patients is higher than the observed incidence in our NF1 population, suggesting that NF1 haploinsufficiency may cause a more severe phenotype with regard to tumor development. In contrast to other reports that associated large deletions with mildly dysmorphic facies, mental retardation and a large number of cutaneous neurofibromas, only one out of our six patients presented this phenotype.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 14 (1995), S. 697-699 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fusarium infection is increasingly reported in immunocompromised patients. The role of central venous catheters as potential portals of entry forFusarium is possibly underestimated. Four cases of catheter-related fusarial infection in children with acute leukemia or a solid tumor are described. These patients had an excellent response to removal of the central venous catheter and treatment with amphotericin B.
    Type of Medium: Electronic Resource
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