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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European radiology 8 (1998), S. 573-581 
    ISSN: 1432-1084
    Keywords: Key words: MRI ; Congenital malformations ; Anorectal malformations ; Associated anomalies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Congenital anorectal malformations are found in many forms, and are frequently associated with other anomalies, especially of the spinal cord, spine, and urogenital system. Decisions concerning initial management of children with anorectal malformations can be made only after accurate determination of (a) the level and type of malformation, (b) the type of fistula, (c) the developmental state of the sphincter muscle complex, and (d) the presence of associated anomalies. Magnetic resonance imaging has proven to be the only modality to answer all these crucial questions, and has contributed to a better insight in the morphology and pathogenesis of such complex congenital malformations.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 65 (1996), S. 609-634 
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 12 (1997), S. 286-288 
    ISSN: 1437-9813
    Keywords: Key words Neuropathic bladder ; Bladder exstrophy ; Continent appendicovesicostomy ; Rhabdomyosarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Treatment of children with severe impairment of bladder function requires a large-volume, low-pressure reservoir combined with a continent, easily catheterizable valve. The Mitrofanoff principle (MP) appears to meet these requirements. Between 1986 and 1993, the MP was applied in 15 children (4 girls) aged 4 to 14 years. The primary diagnosis was bladder exstrophy in 8 (2 girls), neuropathic bladder in 3 (2 girls), urethral valves in 2, and rhabdomyosarcoma (RMS) in 2. In 10 patients bladder augmentation with an intestinal patch was performed in addition to a Mitrofanoff procedure; in 5 a neobladder and continent appendicostomy were made. One boy with RMS died of distant metastases with a well-functioning appendicostomy and adequate renal function. At 2 to 9 years follow-up of the other 14 patients, 12 have a good result defined as: (1) adequate reservoir capacity; (2) continence; (3) normal renal function; and (4) no hydronephrosis. In 1 exstrophy patient with pre-existing impairment of renal function, further deterioration necessitated frequent catheterization and additional medical treatment. In 1 boy with fulgurated urethral valves, spontaneous micturition became subsequently possible, allowing closure of his appendicovesicostomy. Complications occurred in 10 patients, necessitating reintervention in 7. The MP in combination with the creation of an adequate reservoir gives good results in children with severe impairment of bladder function. Careful attention should be given to patient education regarding emptying of the reservoir. Long-term follow-up of renal function is mandatory.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 51 (1995), S. 649-650 
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 12 (1997), S. 286-288 
    ISSN: 1437-9813
    Keywords: Neuropathic bladder ; Bladder exstrophy ; Continent appendicovesicostomy ; Rhabdomyosarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Treatment of children with severe impairment of bladder function requires a large-volume, low-pressure reservoir combined with a continent, easily catheterizable valve. The Mitrofanoff principle (MP) appears to meet these requirements. Between 1986 and 1993, the MP was applied in 15 children (4 girls) aged 4 to 14 years. The primary diagnosis was bladder exstrophy in 8 (2 girls), neuropathic bladder in 3 (2 girls), urethral valves in 2, and rhabdomyosarcoma (RMS) in 2. In 10 patients bladder augmentation with an intestinal patch was performed in addition to a Mitrofanoff procedure; in 5 a neobladder and continent appendicostomy were made. One boy with RMS died of distant metastases with a well-functioning appendicostomy and adequate renal function. At 2 to 9 years follow-up of the other 14 patients, 12 have a good result defined as: (1) adequate reservoir capacity; (2) continence; (3) normal renal function; and (4) no hydronephrosis. In 1 exstrophy patient with preexisting impairment of renal function, further deterioration necessitated frequent catheterization and additional medical treatment. In I boy with fulgurated urethral valves, spontaneous micturition became subsequently possible, allowing closure of his appendicovesicostomy. Complications occurred in 10 patients, necessitating reintervention in 7. The MP in combination with the creation of an adequate reservoir gives good results in children with severe impairment of bladder function. Careful attention should be given to patient education regarding emptying of the reservoir. Long-term follow-up of renal function is mandatory.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-198X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1569-8041
    Keywords: cisplatin ; Cremophor EL ; drug accumulation ; haematopoietic cells ; leukocytes ; paclitaxel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Several clinical studies have shown that poly-chemotherapy with the taxanes paclitaxel or docetaxel preceded or followed by cisplatin is associated with important schedule-dependent differences in toxicities, such as leukocytopenia. In general, the pharmacokinetics of both drugs during the combined treatment are unaltered, suggesting that a pharmacodynamic interaction might have occurred. Materials and methods: In order to gain insight into this pharmacologic interaction, we performed in vitro drug accumulation studies using peripheral blood leukocytes and a panel of tumor and non-malignant cell lines with paclitaxel and docetaxel, as wel as with their respective formulation vehicles Cremophor EL and Tween 80. Results: Our results show a significant reduction in the intracellular cisplatin concentration in leukocytes of up to 42% in the presence of Cremophor EL and Tween 80 as compared to the control. This pharmacodynamic interaction of these surfactants with cisplatin seems to be specific for haematopoietic cells, and does not occur in solid tumor cells. Conclusion: The present data suggest that the pharmaceutical vehicles Cremophor EL and Tween 80 might contribute to the reduced cisplatin-associated myelotoxicity observed in the clinical combination chemotherapy studies with paclitaxel and docetaxel.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Environmental monitoring and assessment 34 (1995), S. 73-102 
    ISSN: 1573-2959
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract A base line study into the environmental quality of soils in the rural areas of the province of Zeeland, the Netherlands, was performed. The polder-landscape in this area was developed in a complex history of floodings and land-reclamation. Samples from 67 sites, at a density of roughly one per 25 km2, were analyzed for As, Cd, Cr, Cu, Hg, Ni, Pb and Zn in addition to a physicochemical characterization by pH(KCl), dry solids, organic matter, and clay content. At about 2/3 of the sites samples were taken at more than one depth. Fluoride and pesticides were determined in partly overlapping selections of 30 samples. Four land use classes were distinguished (arable land, grass land, orchards, uncultivated), and samples were labelled by region within the province. Data evaluation was aided by a recursive statistical approach, whereby statistical tests confirm and strengthen geochemical reasoning. Single- and multivariate statistics were used both as exploratory tools and as a measure of significance and relevance of conditions and processes. In general the environmental quality of the soils is satisfactory. Exceedence of the legal standards for natural background values at more than one site occurs for Cd, Cu, Hg and the pesticides DDT/DDE, dieldrin and HCH, at most by a factor of three. High levels of Hg appear related to arable land use; enhanced levels of Cu are found in orchards. High Cd levels primarily seem to follow a regional or geological pattern; yet, a relation with arable land use and clayey soils cannot be excluded. Pesticides are not detected in grass land, incidence is highest in orchards as well as in uncultivated areas. DDT levels appear to be generally inherited from the past. Variation in soil type as described by the macro physico-chemical characteristics is essential in explaining the variation in concentration level of the potential contaminants. Variations with depth also appear largely related to concurrent variation in soil properties. For As redox conditions and hydrological regime seem of importance, in addition to the geologic history. The influence of atmospheric input is inferred for Pb. The available data do not fully resolve the causes for the regional pattern that remains when the influences of soil type, geology, and land use have been taken into account. In addition to current concentration levels, the base line study offers general insight as to what degree variations in potential contaminants are of natural or anthropogenic origin. A succession of similar studies at suitable time intervals, each with a new selection of sampling sites, may constitute an evolving, flexible monitoring system. When putting up a monitoring system, authorities should weigh the advantages and disadvantages of a network composed of fixed sites against this alternative.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Tropical animal health and production 28 (1996), S. 81-90 
    ISSN: 1573-7438
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Cette revue décrit les 4 espèces de parasites considérées habituellement comme desTheileria en Australie. Les caractéristiques physiologiques et épidémiologiques de ces espèces, présentes chez le bétail, sont ici discutées. La relation entre ces espèces et des espèces bénignes deTheileria dans d'autres pays reste confuse. Des arguments sont présentés en faveur du fait que l'espèce bovine en Australie est correctement identifiée commeTheileria buffeli et que ce nom devrait être utilisé pour les espèces bénignes deTheileria chez le bétail en Eurasie. Les 3 autres espèces présentées dans la revue sont des espèces proposées issues de Marsupiaux. Parmi ces dernières, seuleTheileria tachyglossi peut être inclus dans le genreTheileria, car des schizontes doivent être observés pour les 2 autres espèces.
    Abstract: Resumen Este artículo describe las 4 especies de parásitos incluídas normalmente en el géneroTheileria que se encuentran en Australia. Se discuten las caracteristicas fisiológical y epidemiológicas de las especies que infestan el ganado vacuno. Existe todavía confusión acerca de la relación de dichas especies con otras especies benignas del mismo género que se encuentran en otros paises. Se presentan argumentos que apoyan la opinión de que la especie que se encuentra en el ganado vacuno en Australia debe designarse comoTheileria buffeli y que este nombre debería aplicarse también a todas las especies benignas deTheileria que se encuentran en el ganado vacuno en Eurasia. Las otras 3 especies que se proponen en este artículo se encuentran en animales marsupiales. De todas ellas, sólo la especieTheileria tachyglossi puede ser incluída con certeza en el géneroTheileria, puesto que todavía no se han detectado esquizontes en las otras dos.
    Notes: Summary This review describes 4 species of parasites in Australia generally regarded asTheileria. The physiological and epidemiological characteristics of the species that occurs in cattle are discussed. Confusion still surrounds the relationship of this species with benign species ofTheileria in other countries. Arguments are presented to support the proposal that the bovine species in Australia is correctly designatedTheileria buffeli and that this name should apply to all the benign species ofTheileria of cattle in Eurasia. The other 3 species considered in the review are proposed species from marsupials. Of these, onlyTheileria tachyglossi can confidently be included in the genusTheileria, because schizonts have yet to be detected in the other 2 species.
    Type of Medium: Electronic Resource
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