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  • 1
    Electronic Resource
    Electronic Resource
    Crystallographic and thermodynamic comparison of structurally diverse molecules binding to streptavidin (1995)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 51 (1995), S. 590-596 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Crystallographic structures and thermodynamic binding parameters are compared for three structural classes of streptavidin ligand including d-biotin, 2-[(4′-hydroxyphenyl)-azo] benzoate and the peptide NH2-Phe-Ser-His-Pro-Gln-Asn-Thr-COOH. Descriptions of these structural and thermodynamic observations emphasize the diversity of potential strategies for improving ligand affinity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444995001405
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Experimentelle Rekonstruktion der Orbita beim Schaf mit biodegradablen Implantaten (1998)
    Springer
    Mund-, Kiefer- und Gesichtschirurgie 2 (1998), S. S117 
    Details
    ISSN: 1434-3940
    Keywords: Schlüsselwörter Orbitarekonstruktion ; Resorbierbare Implantate ; Polylaktat ; Key words Orbital reconstruction ; Biodegradable implants ; Polylactide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In a complex animal model in sheep, polydioxanone (PDS®) and polylactic membranes were used for the reconstruction of large orbital-wall defects. In a long-term experiment over 1 year, polylactic implants alone showed the best performance as compared with combinations involving autogenous bone grafts and titanium miniplate fixation. As soon as these polylactic implants are approved for human surgery, they will be used to solve the still challenging problem of anatomical reconstruction of large comminuted fractures of more than one orbital wall.
    Notes: Zusammenfassung In einem experimentellen Modell wurden biodegradierbare Membranen aus Polydioxanon (PDS ® ) resp. Polylaktat zur Rekonstruktion großer Orbitawanddefekte bei Schafen verwendet. Im Langzeitversuch über ein Jahr zeigten diejenigen Rekonstruktionen die besten Resultate, bei welchen ausschließlich biodegradierbare Implantate aus Polylaktat zur Anwendung kamen. Bei gleichzeitiger Verwendung von autologen Knochentransplantaten und Titan-Miniplatten-Osteosynthesen war die anatomische Form der rekonstruierten Orbita weniger zuverlässig gewährleistet. Es darf erwartet werden, dass die klinische Zulassung der Polylaktat-Implantate die chirurgische Wiederherstellung ausgedehnter Trümmerfrakturen mehrerer Orbitawände wesentlich erleichtern wird und zu vorhersehbaren, anatomischen Rekonstruktionen führt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00014455
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Gastroösophagealer Reflux bei systemischer Sklerodermie und Morbus Sharp Verlaufsuntersuchung im Kindes- und Jugendalter (1999)
    Springer
    Monatsschrift Kinderheilkunde 147 (1999), S. 279-282 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Systemische Sklerodermie ; Morbus Sharp ; 24-h-pH-Metrie ; Gastroösophagealer Reflux ; Key words Systemic scleroderma ; Mixed connective tissue disease ; 24-hours pH-metry ; Gastro-esophageal reflux
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Objectives: Esophageal motility disorders and gastroesophageal refluxes are the most frequent gastrointestinal manifestations of progressive systemic sclerosis and Morbus Sharp (”mixed connective tissue disease”). The prognosis of the internal involvements of this uncommon disorders in childhood and adolescence is not well known. Methods: Four patients with systemic sclerosis and two with Morbus Sharp were investigated with two times ambulatory 24-hour esophageal pH-metry for existence and/or degeree of gastro-esophageal reflux. The interval between the two investigations averaged 13,5 months. During this time, none of the patients had symptoms and therefore no H2-antagonists or prokinetic drugs. Results: At both examinations 3/6 patients had an increased percentage of pH〈4. One patient developed retrosternal pain before the second examination. Three patients had an increase of their reflux index. We documented an increase of reflux events lasting for more than 5 min; this result documents a decrease of the esophageal clearance function. Conclusion: In patients with systemic scleroderma or Morbus Sharp a lack of symptoms does not exclude gastroesophageal involvement. In the course of the diseases some of the patients develope a deterioration of the esophageal motility, inspite of immunosuppresive or antiinflammatory therapy. Further studies have to prove the effects of a pre-symptomatic treatment with H2-antagonists or prokinetic drugs on the prognosis of esophageal involvement in systemic scleroderma or Morbus Sharp during childhood.
    Notes: Zusammenfassung Fragestellung:Ösophagusmotilitätsstörungen und gastroösophagealer Reflux sind die häufigsten gastrointestinalen Manifestationen der systemischen Sklerodermie und des Morbus Sharp (mixed connective tissue disease). Über den Spontanverlauf dieser internen Organmanifestationen liegen für das Kindes- und Jugendalter keine Daten vor. Wir untersuchten diese Fragestellung bei pädiatrischen Patienten, die an dieser im Kindesalter seltenen Erkrankung litten, im Rahmen der klinischen Verlaufskontrollen. Patienten und Methode: Es wurden bei 4 Patienten mit systemischer Sklerodermie und 2 Patienten mit Morbus Sharp in 2 24-h-pH-Metrien das Vorliegen und das Ausmaß eines gastroösophagealen Refluxes gemessen. Der durchschnittliche Zeitabstand betrug 13,5 Monate. Während des Beobachtungsintervalls erhielten die Patienten aufgrund fehlender klinischer Symptome keine Säureblocker oder Prokinetika. Ergebnisse: Bei 3/6 Patienten wurde zu beiden Meßzeitpunkten ein erhöhter Refluxindex nachgewiesen. Während nur 1 Patient im Beobachtungszeitraum bis zum Zeitpunkt der Wiedervorstellung und Zweitmessung ein Sodbrennen entwickelte, konnte bei 3 Patienten eine z.T. deutliche Zunahme des gastroösophagealen Refluxes dokumentiert werden. Dabei fand sich insbesondere eine Zunahme der längeren Refluxereignisse als Hinweis auf eine gestörte Clearance-Funktion des distalen Ösophagus. Schlußfolgerung: Das Fehlen klinischer Symptome schließt eine gastroösophageale Beteiligung bei pädiatrischen Patienten mit Sklerodermie und Morbus Sharp nicht aus. Im Spontanverlauf kommt es bei einem Teil der Patienten trotz immunsupressiver und antientzündlicher Therapie der rheumatologischen Grunderkrankung zu einer Progredienz der Ösophagusmotilitätsstörung. Es ist in weiteren Studien zu prüfen, ob eine frühzeitige Therapie mit Prokinetika und H2-Rezeptor-Antagonisten sich im Kindes- und Jugendalter vorteilhaft auf die ösophagealen Komplikationen der systemischen Sklerodermie und des Morbus Sharp auswirkt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050422
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  • 4
    Electronic Resource
    Electronic Resource
    Alternation of interleukin-1α production and interleukin-1α binding sites in mouse brain during rabies infection (1996)
    Springer
    Archives of virology 141 (1996), S. 573-585 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have evaluated the effect of rabies virus infection on interleukin-1α(IL-1α) production and its receptors in mouse brain. Study of virus dissemination in the central nervous system (CNS) showed a massive infection of main brain structures from day 4 post infection (p.i.) up to the agony stage on day 6 p.i. At the same time, IL-1α concentrations increased in cortical and hippocampal homogenates, whereas no change was detected in serum. In non-infected mice, IL-1α binding sites were observed in the dentate gyrus, the cortex, the choroid plexus, the meninges and the anterior pituitary. During rabies virus infection, a striking decrease in IL-1α binding sites was observed on day 4 p.i. with a complete disappearance on day 6 p.i., except in the pituitary gland where they remained at control level. In conclusion, concomitantly with the early rabid pathological signs, brain IL-1α production and IL-1α binding sites are specifically and significantly altered by brain viral proliferation. These results indicate that IL-1α could be involved in the brain response to viral infection as a mediator and could participate in the genesis of the rabies pathogeny.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01718318
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Computer-assisted assignment of peptides with non-standard amino acids (1995)
    Springer
    Journal of biomolecular NMR 5 (1995), S. 183-192 
    Details
    ISSN: 1573-5001
    Keywords: 2D NMR ; Proteins ; Automated assignment ; Graph theory ; Fuzzy mathematics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary A comprehensive peptide assignment program and its application to a cyclic peptide, cyclosporin A, are presented in this paper. A group of graph theoretical algorithms using fuzzy logic are discussed with the aid of examples from cyclosporin A. The algorithms deal with heavily overlapped peaks, recover disjointed and distorted spin coupling networks, and include strategies for sequence-specific assignment. A procedure to extend the Protein Knowledge Base for automatically assigning non-standard amino acid residues is also presented. The program is capable of completely automated assignment for small peptides (∼20 residues). For such molecules, it is insensitive to whether the peptide chain is cyclic or acyclic, and to whether amide protons are present or absent. For larger peptides/proteins, more user interaction is required and the sequence-specific assignment step usually must proceed through fragments smaller than the full length to avoid problems due to occurrence of a combinatorial explosion. The program can be applied as a rigorous tool to check manual assignments. The fuzzy graph theoretical concepts built in the program are illustrated with 2D proton spectra of a peptide, but may be extended to higher-dimensional spectra, other biopolymers, natural products and other organic structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00208809
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  • 6
    Electronic Resource
    Electronic Resource
    N-3 but not N-6 fatty acids reduce the expression of the combined adhesion and scavenger receptor CD36 in human monocytic cells (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Cell Biochemistry and Function 13 (1995), S. 211-216 
    Details
    ISSN: 0263-6484
    Keywords: n-3 polyunsaturated fatty acids ; CD36 ; monocytic cells ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: CD36, a multifunctional adhesion receptor e.g. for thrombospondin and collagen, as well as a scavenger receptor for oxidized low density lipoprotein, is expressed e.g. on platelets and monocytes. By this dual role it might be involved in early steps of atherosclerosis like the recruitment of monocytes and formation of foam cells. We therefore studied the effects of n-3 fatty acids on CD36 expression in human monocytic cells. Incorporation of eicosapentaenoic acid (EPA, C20:5n-3) and docosahexaenoic acid (DHA, C22:6n-3) into cellular phospholipids resulted in a significant reduction of CD36 expression at the mRNA and protein level, whereas arachidonic acid (AA, C20: 4n-6) and linoleic acid (LA, C18:2n-6) tended to increase CD36 expression compared to the control. This specific down-regulation of CD36 by n-3 fatty acids in cells involved in the initiation and progression of atherogenesis and inflammation, represents a further mechanism that may contribute to the beneficial effects of n-3 polyunsaturated fatty acids (PUFA) in these disorders.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cbf.290130312
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  • 7
    Electronic Resource
    Electronic Resource
    Lovastatin induces differentiation of Mono Mac 6 cells (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Cell Biochemistry and Function 13 (1995), S. 273-277 
    Details
    ISSN: 0263-6484
    Keywords: adhesion ; HMG-CoA reductase ; HUVEC ; mevalonate ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The proliferation of human monocytic Mono Mac 6 cells was significantly retarded by treatment with lovastatin (LOV, 10 μM) for 72 h. Treatment of Mono Mac 6 cells with LOV increased surface protein expression of monocyte-associated CD14 and the integrin-chain CD11b towards levels found in isolated human blood monocytes. These effects were dose-dependent and completely reversed by the isoprenoid precursor mevalonate (MVA). LOV failed to induce growth retardation and upregulation of CD11b or CD14 in the less mature premonocytic U937 cell line. While CD11b expression was comparable in Mono Mac 6 cells treated with LOV (10 μM), TNF (100 U ml-1) or LPS (10 ng ml-1), upregulation of CD14 by LOV was less pronounced. Basal CD23 expression was unaffected by LOV but markedly reduced by treatment with TNF or LPS. Moreover, LOV enhanced Mono Mac 6 adhesiveness to human umbilical vein endothelial cells to levels found in isolated human blood monocytes, probably due to the increased CD11b and CD14 expression. In conclusion, LOV can induce differentiation of monocytic cells which is reflected by the retardation of growth, expression of CD14 and CD11b, and enhanced adhesiveness.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cbf.290130408
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