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  • 1
    Electronic Resource
    Electronic Resource
    The Collaborative Randomised Amnioinfusion for Meconium project (CRAMP): 2. Zimbabwe (1998)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 105 (1998), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To evaluate transcervical amnioinfusion for meconium stained amniotic fluid during labour.Design Multicentre randomised controlled trial.Setting A large urban academic hospital. Electronic fetal heart rate monitoring was not used.Participants Women in labour at term with moderate or thick meconium staining of the amniotic fluid.Interventions Transcervical amnioinfusion of 500 mL saline over 30 minutes, then 500 mL at 30 drops per minute. The control group received routine care. Blinding of the intervention was not possible.Main outcome measures Caesarean section, meconium aspiration syndrome and perinatal mortality.Results There was no difference in risk for caesarean section in the two groups (amnioinfusion 9.5%vs control 12.3%; RR 0.84, 95% CI 0.53–1.32). Meconium aspiration syndrome was significantly less frequent in the amnioinfusion group (3.1%vs 12.8%; RR 0.24, 95% CI 0.12–0.48), and there was a trend towards fewer perinatal deaths (1.2%vs 3.6%; RR 0.34, 95% CI 0.11–1.06).Conclusions Amnioinfusion is technically feasible in a developing country situation with limited intrapartum facilities. In this study amnioinfusion for meconium stained amniotic fluid was associated with striking improvements in perinatal outcome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1998.tb10092.x
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  • 2
    Electronic Resource
    Electronic Resource
    Uptake and nuclear transport of Neisseria IgA1 protease-associated α-proteins in human cells (1995)
    Osney Mead, Oxford OX2 0EL, UK : Blackwell Scientific Publications
    Molecular microbiology 17 (1995), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Pathogenic Neisseria species, the causative agents of gonorrhoea and bacterial meningitis, encode a family of polymorphic exo-proteins which are autoproteolytically processed into several distinct extracellular components, including an IgA1 protease and an α-protein. IgA1 protease, a putative virulence determinant, is a sequence-specific endopeptidase known to cleave human IgA1, but additional target proteins have been postulated. The physical linkage of IgA1 protease and a-protein suggests a functional relationship of both precursor components. Previous work has shown that α-protein is essential neither for extracellular transport nor for the proteolytic activity of IgA1 protease. Intriguingly, α-proteins carry amino acid sequences reminiscent of nuclear location signals of viral and eukaryotic proteins. Here we demonstrate the functionality of these nuclear location signal sequences in transfected eukaryotic cells. Chimeric α-proteins show nuclear transport and selectively associate with nucleolar structures. More importantly, native purified α-proteins are capable of entering certain human primary cells from the exterior via an endocytotic route and accumulate in the nuclei. The neisserial α-proteins share several features with eukaryotic transcription factors, such as the formation of dimers via a heptad repeat sequence. We propose a role for a-proteins in the regulation of host-cell functions. As the α-proteins are covalently connected with IgA1 protease they may also serve as carriers for the IgA1 protease into human cells where additional proteolytic targets may exist. Neisseria meningitidis, which locally colonizes the nasopharyngeal mucosa of many human individuals without apparently causing symptoms, secretes this nucleus-targeted factor in large quantities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_17061073.x
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  • 3
    Electronic Resource
    Electronic Resource
    Cross-reactivity between
T cells and bacteria (1999)
    Copenhagen : Munksgaard International Publishers
    Allergy 54 (1999), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.1999.00302.x
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  • 4
    Electronic Resource
    Electronic Resource
    Erklären und Verstehen in der Psychiatrie (1998)
    Springer
    Der Nervenarzt 69 (1998), S. 386-389 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Erklären ; Verstehen ; Erkenntnislehre ; Theorie der Psychiatrie ; Key words Explanantion ; Understanding ; Epistemology ; Theory of psychiatry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The philosophical debate on explanation and understanding also led to basic methodological reflections in psychiatry. Subsuming one fact under a general law is the characteristic feature of scientific explanations. In this way, deductive conclusions can be achieved with a high degree of objectivity. Hermeneutical understanding makes way for interpretations in front of a given theoretical matrix. On the other hand, sympathetic understanding is a matter of conceiving single-part items as a consequence of other singular aspects (e.g., tracing back an action to an intention). If one understands the growth of knowledge as a rational and critical process, it seems no more justified to insist on exclusive methodologically based positions.
    Notes: Zusammenfassung Die philosophische Debatte um Erklären und Verstehen hat auch zu grundsätzlichen methodischen Reflexionen in der Psychiatrie geführt. Kennzeichnend für wissenschaftliche Erklärungen ist die Subsumtion eines Einzelsachverhaltes unter eine allgemeine Regel. Auf diese Weise erhält man deduktiv Schlußfolgerungen mit einem hohen Grad an Objektivität. Beim nachfühlenden Verstehen geht es darum, Einzelsachverhalte als Folge anderer singulärer Momente zu begreifen (z.B. die Zurückführung einer Handlung auf eine Intention). Hermeneutisches Verstehen ermöglicht hingegen Interpretationen vor dem Hintergrund einer gegebenen theoretischen Matrix. Betrachtet man den Fortschritt des Wissens insgesamt als einen rationalen und kritischen Prozeß, dann erscheinen allerdings methodenzentrierte Standpunkte nicht mehr plausibel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050287
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  • 5
    Electronic Resource
    Electronic Resource
    Antagonismus in vivo von fluoreszierenden Pseudomonaden gegenüber Rhizoctonia solani und Pythium aphanidermatum an Gurken und Buschbohnen (1995)
    Springer
    Journal of pest science 68 (1995), S. 3-8 
    Details
    ISSN: 1612-4766
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Zusammenfassung Fluoreszierende Pseudomonaden, die sich als Antagonistenin vitro gegenüberRhizoctonia solani undPythium aphanidermatum erwiesen haben, wurden an Gurken und Bohnen auf Antagonismusin vivo untersucht. Die Effizienz der Antagonisten in Auflaufversuchen gegenüberR. solani war niedriger als beiP. aphanidermatum. Die besten Isolate konnten in mitR. solani verseuchter Erde Auflaufraten von 30–40% erzielen, gegenüberP. aphanidermatum dagegen 40–60%. Die Wirkung der Antagonisten zur Verhütung von Spätinfektionen der Pflanzen war deutlich besser. So konnten 16 Isolate eine Schädigung durchR. solani an Bohnen zwischen 90 und 100% reduzieren. An Gurken konnten 12 Isolate eine Schädigung durchP. aphanidermatum auf 70–80% reduzieren.
    Notes: Abstract Fluorescent pseudomonads, which showed antagonism in vitro against Rhizoctonia solani and Pythium aphanidermatum, were investigated for antagonism in vivo using bean and cucumber. The efficiency of the antagonists in germination tests against Rhizoctonia solani was lower than against Pythium aphanidermatum. In soil infected with Rhizoctonia solani the germination rates of the seeds remained between 30 and 40%, whereas against Phytium aphanidermatum some Pseudomonas-strains caused germination rates of 40–60%. The preventive effect of the antagonists against fungal infection after the germination was better. 16 isolates reduced the damage caused by Rhizoctonia solani to bean between 90 and 100%. Damage caused by Pythium aphanidermatum to cucumber was reduced by 12 antagonists between 70 and 80%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01980347
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  • 6
    Electronic Resource
    Electronic Resource
    The Carnot Heterogeneous Database Project: Implemented Applications (1997)
    Springer
    Distributed and parallel databases 5 (1997), S. 207-225 
    Details
    ISSN: 1573-7578
    Keywords: enterprise integration ; workflow management ; agents interoperation ; heterogeneous databases ; scientific decision support ; data mining
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract The Carnot project was an ambitious research project inheterogeneous databases. It integrated a variety of techniques toaddress a wide range of problems in achieving interoperation inheterogeneous environments. Here we describe some of the majorimplemented applications of this project. These applications concern(a) accessing a legacy scientific database, (b) automating a workflowinvolving legacy systems, (c) cleaning data, and (d) retrievingsemantically appropriate information from structured databases inresponse to text queries. These applications support scientificdecision support, business process management, data integrityenhancement, and analytical decision support, respectively. Theydemonstrate Carnot‘s capabilities for (a) heterogeneous queryprocessing, (b) relaxed transaction and workflow management, (c)knowledge discovery, and (d) heterogeneous resource modelintegration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008645509474
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