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  • 1
    Electronic Resource
    Electronic Resource
    Simvastatin reduces activation of normal platelets by LDL isolated from patients with familial hypercholesterolaemia and familial defective apolipoprotein B (1997)
    Springer
    European journal of clinical pharmacology 53 (1997), S. 277-279 
    Details
    ISSN: 1432-1041
    Keywords: Key words Platelet aggregation simvastatin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050377
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  • 2
    Electronic Resource
    Electronic Resource
    Design of surface forces apparatus for tribology studies combined with nonlinear optical spectroscopy (1997)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 68 (1997), S. 2499-2504 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We describe the design, calibration, and performance of surface forces apparatus with the capability of illumination of the contact interface for spectroscopic investigation using optical techniques. The apparatus can be placed in the path of a Nd-YAG laser for studies of the linear response or the second harmonic and sum-frequency generation from a material confined between the two surfaces. In addition to the standard fringes of equal chromatic order technique, which we have digitized for accurate and fast analysis, the distance of separation can be measured with a fiber-optic interferometer during spectroscopic measurements (2 Å resolution and 10 ms response time). The sample approach is accomplished through application of a motor drive, piezoelectric actuator, or electromagnetic lever deflection for variable degrees of range, sensitivity, and response time. To demonstrate the operation of the instrument, the stepwise expulsion of discrete layers of octamethylcyclotetrasiloxane from the contact is shown. Lateral forces may also be studied by using piezoelectric bimorphs to induce and direct the motion of one surface. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1148148
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  • 3
    Electronic Resource
    Electronic Resource
    Three New Polymorphic Forms of Molybdenum Pentachloride (1997)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 53 (1997), S. 895-903 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Three new polymorphic modifications of molybdenum pentachloride could be obtained by solvothermal syntheses in CCl4 and SbCl5 as solvents. The structures have been solved by single-crystal X-ray diffraction. The already known structure of monoclinic \alpha-MoCl5 (C2/m) is not isomorphous with \alpha-NbCl5 and is better derived from the closest packing of Cl atoms of the Sm type with molybdenum occupying 1/5 of the octahedral holes. The triclinic structure of \beta-MoCl5 (P\overline 1) can be derived from hexagonal closest packing. The orthorhombic structure of \gamma-MoCl5 (Pnma) and the monoclinic structure of \delta-MoCl5 (P21/c) can both be derived from double-hexagonal closest packing. All four forms of MoCl5 have in common the discrete Mo2Cl10 moieties built from edge-sharing double octahedra with the metal atoms displaced from the octahedron centres away from each other. The differences between the modifications lie in the different stacking sequences of the close-packed Cl-atom layers and the different occupation of the octahedral interstices. This is reflected in the group–subgroup relationships of the space groups of the closest packings and the molybdenum pentachlorides. X-ray powder diffraction shows that sublimed MoCl5 is a mixture of all four modifications in variable amounts and probably a further unknown form.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108768197008331
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  • 4
    Electronic Resource
    Electronic Resource
    Spontaneous pinwheel annihilation during visual development (1998)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 395 (1998), S. 73-78 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Neurons in the visual cortex respond preferentially to edge-like stimuli of a particular orientation. It is a long-standing hypothesis that orientation selectivity arises during development through the activity-dependent refinement of cortical circuitry. Unambiguous evidence for such a process ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/25736
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  • 5
    Electronic Resource
    Electronic Resource
    Organization of the visual cortex (1996)
    [s.l.] : Nature Publishing Group
    Nature 382 (1996), S. 306-306 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - One long-standing question in developmental neuroscience is whether the functional architecture of the visual cortex is epigenetically induced by activity-dependent mechanisms or whether it is prespecified by genetic instructions1'2. It is widely assumed that dependence on experience and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/382306a0
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  • 6
    Electronic Resource
    Electronic Resource
    Anticardiolipin antibodies do not seem to be associated with APC resistance in vivo or in vitro (1995)
    Springer
    Annals of hematology 71 (1995), S. 195-198 
    Details
    ISSN: 1432-0584
    Keywords: Key words Anticardiolipin antibodies ; Lupus anticoagulants ; APC resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Anticardiolipin antibodies (aCL) or lupus anticoagulants (LA) have been found to exert an inhibitory action upon the activation and function of protein C, a natural coagulation inhibitor. Recently an in vitro phenomenon called resistance to activated protein C (APC resistance) has been described as the most frequent cause of hereditary thrombophilia. In order to see whether a positive association of APC resistance with aCL exists we examined plasma of 162 consecutive outpatients referred for thrombophilia screening. Further, the IgG fraction was isolated from plasma of two aCL-positive and LA-negative patients and of two aCL-negative healthy subjects by means of protein A affinity chromatography. Each of these isolates was mixed with normal plasma, and the APC resistance was assayed; 25/162 (15.4%) patients had confirmed abnormal APC resistance. Only 1/25 (4.0%) APC resistance-positive patients and 11/137 (8.0%) APC resistance-negative patients had positive IgG- and/or IgM-aCL (p=0.5, nonsignificant). In the in vitro test system the APC resistance ratio remained unaffected after addition of normal IgG or aCL-IgG fraction in the tested normal plasma and did not deviate from the range of buffer controls. These data do not suggest any association of aCL with abnormal APC resistance. aCL-IgG fractions from aCL-positive and LA-negative plasmas do not interfere with the APC resistance test system in vitro in low concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01910318
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  • 7
    Electronic Resource
    Electronic Resource
    Anticardiolipin antibodies do not seem to be associated with APC resistance in vivo or in vitro (1995)
    Springer
    Annals of hematology 71 (1995), S. 195-198 
    Details
    ISSN: 1432-0584
    Keywords: Anticardiolipin antibodies ; Lupus anticoagulants ; APC resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Anticardiolipin antibodies (aCL) or lupus anticoagulants (LA) have been found to exert an inhibitory action upon the activation and function of protein C, a natural coagulation inhibitor. Recently an in vitro phenomenon called resistance to activated protein C (APC resistance) has been described as the most frequent cause of hereditary thrombophilia. In order to see whether a positive association of APC resistance with aCL exists we examined plasma of 162 consecutive outpatients referred for thrombophilia screening. Further, the IgG fraction was isolated from plasma of two aCL-positive and LA-negative patients and of two aCL-negative healthy subjects by means of protein A affinity chromatography. Each of these isolates was mixed with normal plasma, and the APC resistance was assayed; 25/162 (15.4%) patients had confirmed abnormal APC resistance. Only 1/25 (4.0%) APC resistance-positive patients and 11/137 (8.0%) APC resistance-negative patients had positive IgG- and/or IgM-aCL (p=0.5, nonsignificant). In the in vitro test system the APC resistance ratio remained unaffected after addition of normal IgG or aCL-IgG fraction in the tested normal plasma and did not deviate from the range of buffer controls. These data do not suggest any association of aCL with abnormal APC resistance. aCL-IgG fractions from aCL-positive and LA-negative plasmas do not interfere with the APC resistance test system in vitro in low concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01910318
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  • 8
    Electronic Resource
    Electronic Resource
    NMR monitoring of rheumatoid arthritis patients receiving anti-TNF-α monoclonal antibody therapy (1997)
    Springer
    Rheumatology international 16 (1997), S. 249-255 
    Details
    ISSN: 1437-160X
    Keywords: Dynamic MRI ; Rheumatoid arthritis ; Biological response modifiers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to investigate if dynamic gadolinium-DTPA-supported magnetic resonance (MR) imaging can monitor the therapeutic effect of a fast-acting immuno-modulating drug like anti-tumour necrosis factor alpha (anti-TNF-α) monoclonal antibody (moab) in patients with rheumatoid arthritis (RA). Dynamic MR imaging was performed on 64 joints in a total of 18 patients before and after infusion with either a placebo or 1 or 10 mg/kg of anti-TNF-α moab. Additionally, treating the placebo group and reinfusing the verum group with either 3 or 10 mg/kg was monitored by quantitative nuclear magnetic resonance (NMR). Time-dependent signal intensity changes were then correlated with a total of five Paulus criteria and with ESR and C-reactive protein (CRP). No changes in either the gadolinium uptake or clinical parameters were seen after the infusion of a placebo. Therapy with 1 mg/kg anti-TNF-α moab resulted in a significant decrease in clinical disease activity, as well as in gadolinium-DTPA uptake in dynamic NMR studies. However, correlations between signal intensity changes and Paulus criteria were only demonstrated for the variable “doctor's evaluation of disease activity”. Patients given 10 mg/kg moab demonstrated a very significant improvement in all clinical manifestations of their disease, as well as a high significant reduction in gadolinium uptake (P=0.004). In addition, the latter group showed significant correlations between time-dependent signal intensity changes and five Paulus criteria: “number of swollen joints”, “number of painful joints”, “duration of morning stiffness”, “doctor's evaluation of disease activity” and “patient's evaluation of disease activity”. No differences and correlations were seen for ESR and CRP. We concluded that dynamic NMR studies are suitable to monitor inflammatory activity in RA patients under therapy with biological response modifiers such as anti-TNF-α moab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01375657
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  • 9
    Electronic Resource
    Electronic Resource
    99m-Tc-HMPAO-SPECT in diagnosis of early cerebral vasculitis (1996)
    Springer
    Rheumatology international 16 (1996), S. 37-42 
    Details
    ISSN: 1437-160X
    Keywords: Systemic vasculitis ; CNS involvement ; Neurologic symptoms ; 99m-Tc-HMPAO-SPECT imaging ; Early detection and prevention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The objective of this study was to evaluate whether mild neurological symptoms suggestive of neuropsychiatric involvement may be associated with cerebral perfusion defects as detected by functional brain imaging with 99m-Tc-HMPAO-SPECT (single photon emission computed tomography). SPECT analysis for the early detection of central nervous system (CNS) involvement was evaluated in 40 consecutive patients with systemic vasculitis or with Sneddon's syndrome. Of these, 18 patients showed overt neuropsychiatric symptoms, so-called major symptoms (e.g. motoric or sensible defects); 6 had mild symptoms like headache or cognitive disorders, so-called minor symptoms; 16 patients did not present with any of these symptoms. SPECT abnormalities were detected in 16 of the 18 patients with overt neuropsychiatric symptoms (89%). Five of the 6 patients with minor symptoms (83%) and 5 of the 16 patients without neurological symptoms (31 %) also had SPECT abnormalities. There was no relation to disease activity or duration. We concluded that the high sensitivity of SPECT (87.5%) in detecting perfusion abnormalities among the evaluated group of patients indicates its suitability for early diagnosis of vasculitic CNS involvement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01419953
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  • 10
    Electronic Resource
    Electronic Resource
    Treatment of AIDS-related non-Hodgkin's lymphoma with chemotherapy (CNOP) and r-hu-G-CSF: Clinical outcome and effect on HIV-1 viral load (1998)
    Springer
    Annals of oncology 9 (1998), S. 1135-1138 
    Details
    ISSN: 1569-8041
    Keywords: AIDS ; chemotherapy ; G-CSF ; HIV-1 viral replication ; non-Hodgkin's lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: The optimal treatment of AIDS-related NHL (ARL) has yet to be defined. The purpose of this study was 1) to evaluate the efficacy and toxicity of the CNOP-regimen (cyclophosphamide, mitoxantrone, vincristine, and prednison) in combination with G-CSF; and 2) to study the effect of this regimen on HIV-1 viral replication. Patients and methods: A phase II study was performed in 21 previously untreated patients with ARL. Results: Based on intention to treat, the response rate was 43%: four complete and five partial remissions. Median survival was only five months. Only one patient had an opportunistic infection during treatment; three patients had localized infections and one episode of septicaemia was seen. Remarkably, during treatment, in 94% of cases p24 antigen levels either remained undetectable or showed a substantial decrease, even though antiretroviral therapy had been discontinued just prior to the first cycle of chemotherapy in all patients. HIV-1 RNA load decreased or remained unchanged in 82% of patients and increased in three patients. Conclusions: Our data demonstrate, 1) that the CNOP-regimen in combination with G-CSF, although associated with a low risk of both opportunistic and bacterial infections, can not be recommended in the treatment of ARL; but 2) that G-CSF can be used safely to sustain haematopoiesis in patients with ARL treated with chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008484522952
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