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  • Articles: DFG German National Licenses  (9)
  • 1990-1994  (9)
  • 1
    Electronic Resource
    Electronic Resource
    Structure of a Myristoyl-ACP-Specific Thioesterase from Vibrio harveyi (1994)
    s.l. : American Chemical Society
    Biochemistry 33 (1994), S. 9382-9388 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00198a003
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Risk factors for adverse drug reactions — epidemiological approaches (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 321-325 
    Details
    ISSN: 1432-1041
    Keywords: risk factor ; adverse drug reactions ; epidemiological approach ; aspirin ; benzodiacepines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Age by itself is not an important risk factor for ADRs. Age-related changes are the consequence of a number of individual factors, for example morbidity associated with polypharmacy, decline in renal or liver function in the elderly, hypoalbuminaemia, reduced body weight, etc. The relationship between gastrointestinal bleeding and non-steroidal anti-inflammatory drugs can be assessed globally in large cohort studies with access to computerized data, but complete accuracy requires access to the original patient records. The increase in the risk of GI bleeding in users of NSAIDs and aspirin was 50% above that in non-users. About a quarter of ADRs in hospitalized patients seem not to arise from purely pharmacological mechanisms. They are mainly due to allergic, anaphylactoid, or idiosyncratic reactions and to intolerance. In such non-pharmacological reactions, the time of exposure, reaction time, and even dosage may be important factors in identification of the causal drug. The use of benzodiazepines can be optimized by taking into account potency, time of action and the different syndromes encountered after withdrawal. Following long-term use problems of relapse and rebound are being increasingly recognized, in addition to organic withdrawal symptoms. In psychiatric patients extrapyramidal disorders due to neuroleptics are common. The rates of these ADRs differ markedly between various drugs, even after dosages and co-medications are taken into account. Epidemiological screening for potentially carcinogenic drugs can only be done in large cohorts of patients with pre-recorded full information sets as may be found in an HMO (Health Maintenance Organization). The findings of several such studies have been published in specialist cancer journals. However, most of the associations observed should only be viewed as hypotheses for further investigation. In a classical twenty-year follow-up study of a cohort of phenacetin abusers, there was an excess of patients with renal insufficiency and death related to renal and urogenital causes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315403
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A novel platinum reagent [chloro(2,2':6',2''-terpyridine)platinum(II) chloride] for use in heavy-atom derivatization of protein crystals (1994)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 50 (1994), S. 332-334 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: A platinum chromophore, chloro(2,2′:6′,2′′-terpyridine)platinum(II) chloride, previously used in labelling active-site histidines of serine proteases, proves to be a useful reagent in heavy-atom derivatization of protein crystals for X-ray crystallographic phase determination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444993013113
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Lignin analyzer based on pyrolysis-mass spectrometry of pulp in hydrogen or helium (1990)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 61 (1990), S. 1958-1965 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The lignin content of wood, paper, pulp, or other materials containing lignin (such as filter paper soaked in black liquor) is readily determined by flash pyrolysis of the sample at approximately 550 °C in a reducing atmosphere of hydrogen or in an inert atmosphere of helium followed by a rapid analysis of the product gas by a mass spectrometer. The heated pyrolysis unit as fabricated, comprises a small platinum cup welded to an electrically heated stainless-steel ribbon with control units for programmed short duration (1.5 s, approximately) heating and for continuous flow of hydrogen or helium. The pyrolysis products enter an electron-ionization-mode mass spectrometer for spectral evaluation. Lignin content is obtained from certain ratios of integrated ion currents of many mass spectral lines, the ratios being linearly related to the Kappa number or Klason lignin. The Kappa number can be obtained from a few milligram sample in 3 min which is at least ten times faster than a Kappa number determination by the Standard Chemical Method. The present instrument can measure Kappa numbers in the whole range from 0 to 200 without any readjustments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1141402
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex (1991)
    [s.l.] : Nature Publishing Group
    Nature 351 (1991), S. 491-494 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Many factors have been suggested to trigger the activation of lipase at a lipid-water interface. They included increase of substrate concentration at the interface6, better orientation of the scissile ester bond7, reduction in the water shell around the ester molecules In water8 and a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/351491a0
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Is ATP synthesized by a vacuolar-ATPase in the extremely halophilic bacteria? (1993)
    Springer
    Cellular and molecular life sciences 49 (1993), S. 1059-1063 
    Details
    ISSN: 1420-9071
    Keywords: Halobacterial ATPase ; archaeal ATPases ; ATP synthesis ; Halobacterium ; Haloarcula ; Haloferax
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The proton-dependent synthesis of ATP was demonstrated in representative members of the generaHalobacterium, Haloarcula, andHaloferax. In all cases, synthesis was not inhibited by nitrate or N-ethylmaleimide, inhibitors of the vacuolar-like ATPase found in Archaea, but was affected by azide, an inhibitor of F0F1-ATP syntheses. These observations extend the earlier observations withHalobacterium saccharovorum and suggest that ATP synthesis in these organisms is brought about by an F0F1-APT synthase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01929914
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of CGRP antagonist, alpha-CGRP 8-37, on acid secretion in the dog (1994)
    Springer
    Digestive diseases and sciences 39 (1994), S. 1405-1408 
    Details
    ISSN: 1573-2568
    Keywords: calcitonin gene-related peptide ; CGRP antagonist ; alpha-CGRP 8-37 ; gastric acid secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The recently synthesized calcitonin gene-related peptide (CGRP) antagonist, human alpha-CGRP 8-37, was used to study its effects on gastric acid secretion. Four dogs with gastric fistula were used to measure the antagonist's physiologic effects in the stomach. All dogs received a bactopeptone dextrose meal (intragastric titration to pH 5.5) with either continuous CGRP 8-37 (1000 pmol/kg/hr) or saline (control). Additionally, intravenous bombesin (75–600 ng/kg/hr) and bethanecol (12.5–100 µg/kg/hr) was tested in the presence of the antagonist. Plasma gastrin levels also were measured via radioimmunoassay (RIA) in control and CGRP 8-37-stimulated animals. Gastric acid secretion increased by 100% with infusion of 1000 pmol/kg/hr CGRP 8-37 when compared to the control. Acid output increased 98% with both intravenous antagonist and 600 ng/kg/hr bombesin when compared to bombesin alone. However, no augmentation of acid secretion by CGRP 8-37 was shown with 25 µg/kg/hr bethanecol. RIA of plasma gastrin demonstrated no effect with the antagonist when given alone and did not increase bombesin-stimulated gastrin release. We conclude that CGRP 8-37 blocks native CGRP inhibitory effects on gastric acid secretion. Our findings of potentiation of acid secretion by bombesin as well as no change in gastrin levels in the presence of the antagonist is likely due to a blockage in a noncholinergic neuron to the somatostatin cell. Furthermore, CGRP 8-37 did not increase bethanecolstimulated acid secretion, most likely due to bethanecol's (acetylcholine) nearly ubiquitous positive effects on acid secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02088041
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  • 8
    Electronic Resource
    Electronic Resource
    Influence of tobacco leaf surface chemicals on germination ofPeronospora tabacina adam sporangia (1990)
    Springer
    Journal of chemical ecology 16 (1990), S. 1565-1576 
    Details
    ISSN: 1573-1561
    Keywords: Nicotiana ; Solanaceae ; Peronospora tabacina ; blue mold ; Alternaria alternata ; leaf surface chemistry ; diterpenes ; sucrose esters ; hydrocarbons ; spore germination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Chromatographic procedures were utilized to isolate and purify components of tobacco cuticular extracts and leaf surface chemicals.In vitro microbial bioassays determined the influence of these leaf surface compounds on germination and germ tube morphology ofP. tabacina sporangia, the tobacco blue mold pathogen, and to a lesser extentAlternaria alternata, the tobacco brown spot pathogen. Exposure to 10 μg/cm2 of α- and β-duvatrienemonols, sucrose esters, or hydrocarbons did not inhibit germination, whereas germination was significantly decreased bycis-abienol.cis-Abienol did not inhibit sporangial germination when combined with sucrose esters or hydrocarbons at a combined 10 μg/cm2. Germination of sporangia was completely inhibited by α- and β-duvatrienediols. In contrast to a previous report, α-DVT-diol was more inhibitory than the β isomer. Toxic effects of the DVT-diols were not altered by pH. Diluting the DVT-diols to less than 0.1 μg/cm2 resulted in a small but significant stimulation of germination. Previously, the DVT-diols had been identified only as inhibitory toP. tabacina. None of the leaf surface chemicals affected germination ofA. alternata conidia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01014090
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Cloning and sequencing of cDNAs encoding the actin cross-liking protein transgelin defines a new family of actin-associated proteins (1994)
    New York, NY : Wiley-Blackwell
    Cell Motility and the Cytoskeleton 28 (1994), S. 243-255 
    Details
    ISSN: 0886-1544
    Keywords: cytoskeleton ; actin binding ; transgelin sequence ; gelation ; gene family ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: We have used degenerate oligonucleotides, derived from the amino acid sequence of transgelin peptides [Shapland et al., 1993: J. Cell Biol. 121:1065-1073], to isolate and sequence overlapping cDNA clones encoding this actin gelling protein. Primers with 5′ restriction enzyme sites directed against the N and C terminal amino acids present in these clones were then used to amplify and clone the entire transgelin coding region from reverse transcribed rat small intestine cDNA (RT-PCR). These studies have shown that transgelin is the product of a single gene which is conserved between yeast, Drosophila, molluscs, and humans. Transgelin is expressed as a single message that is regulated at the level of transcription in SV40 transformed 3T3 cells. Our data have shown that transgelin and several other proteins of unknown function, SM22α [Pearlstone et al., 1987: J. Biol. Chem. 262:5985-5991], mouse p27 [Almendral et al., 1989: Exp. Cell Res. 181:518-530], and human WS3-10 [Thweatt et al., 1992: Biochem. Biophys. Res. Commun. 187:1-7], share extensive homology. More limited regions of homology shared between transgelin and other proteins such as rat NP25 (unpublished), chicken calponins α and β [Takahashi and Nadal-Ginard, 1991: J. Biol. Chem. 266:13284-13288], and Drosophila mp20 [Ayme-Southgate et al., 1989: J. Cell Biol. 108:521-531] suggest that all of these proteins may be classified as members of a new transgelin multigene family. © 1994 Wiley-Liss, Inc.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cm.970280307
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