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  • Electronic Resource  (7)
  • 1990-1994  (5)
  • 1975-1979  (2)
  • 1
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We evaluated membrane expression and function of complement receptors CR1 and CR3 on neutrophils from 27 HIV-positive (HIV+) subjects (14 in the CDC class III and 13 class IV) as well as their modulation in vitro by recombinant tumour necrosis factor-α (rTNF-α) and granulocyte-macrophage colony stimulating factor (rGM-CSF). While CR1 was expressed at similar levels on neutrophils from controls and HIV+ subjects. CR3 expression was significantly higher in CDC class IV subjects than in healthy controls. CR1 and CR3 expression was significantly increased after treatment of neutrophils with both cytokines, without differences between controls and HIV+ subjects. Similarly, the superoxide anion (O2) production in response to C3-coated zymosan (C3zy) was significantly enhanced on neutrophils from CDC class IV subjects when compared with controls. rGM-CSF and rTNF-α treatment significantly enhanced the spontaneous as well as C3zy-stimulated O2 production by neutrophils from controls and CDC class III subjects, and induced an upward trend in the CDC class IV group. These results indicate that the neutrophils of HIV+ patients are preactivated in vivo but they also indicate that these cells may correctly respond to a subsequent particulate stimulus as well as to activating cytokines. Our findings suggest that desensitization or functional exhaustion of complement receptors are not implicated in the abnormalities observed on neutrophils from HIV+ patients.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 344-345 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The asymmetry would arise in a ring of synchronously rotating, irregularly shaped, particles if there was a statistical tendency for the long axes of the particles to be inclined in the trailing sense with respect to the differential rotation. Such an orientation of the axes of the particles could ...
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 102-104 (Jan. 1992), p. 271-278 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1572-9648
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Description / Table of Contents: Summary A Shuttle-borne tethered satellite has the potential of contributing significantly to the scientific versatility of the Shuttle Orbiter, that will be launched by NASA in the early '80s. If the Shuttle is in a 200 km orbit, the use of a 100 km tether connected to the Shuttle at one end and to the satellite at the other makes the performance of various relevant electromagnetic measurements in the magnetosphere possible. The tethered satellite (a subsatellite) can also be lowered from the Shuttle down to heights in the vicinity of 100 km, to an altitude band that has great importance from the standpoint of both upper atmospheric experimentation and gravity-gradient measurements. From a preliminary analysis, we find that one of the major problem areas of the system — the heating of the wire and of the subsatellite due to air drag — can be solved within the present state of the art in wire technology and heat shielding. System masses are also reasonable: In fact, a system with a 100 km wire and a Shuttle-borne reel, tethering a 100 kg subsatellite, would have a mass no larger than 120 kg.
    Notes: Sommario Satelliti collegati con cavo allo Shuttle in orbita contribuiscono in modo significativo alla versatilità del veicolo. Se lo Shuttle è in orbita a 200 km di altezza, l'uso di un cavetto lungo 100 km attaccato con un estremo allo Shuttle e con l'altro ad un satellite rende possibile una grande varietà di misure elettromagnetiche nella magnetosfera. Il satellite collegato con cavo (un sottosatellite) può essere calato dallo Shuttle giù fino ad altezze dell'ordine di 100 km in una banda di quote che ha una enorme importanza dal punto di vista della sperimentazione dell'alta atmosfera ed inoltre dal punto di vista della misura del gradiente di gravità. Dall'analisi preliminare abbiamo trovato che uno dei maggiori problemi che presenta il sistema, il riscaldamento del filo e del satellite dovuto alla resistenza dell'aria, può essere risolto nell'ambito del presente stato dell'arte nella tecnologia dei cavi e dell'isolamento termico. Le masse del sistema sono anche ragionevoli; infatti un sistema con un cavo lungo 100 km ed un rocchetto sullo Shuttle, collegante un sottosatellite di 100 kg, verrebbe ad avere una massa di 120 kg.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 83 (1994), S. 207-215 
    ISSN: 1573-2878
    Keywords: Differential inclusions ; state constraints ; regulation maps
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract In this note, a perturbed control problem with state constraints depending on a parameteru is considered. Assuming that, for a certain value ofu, there exists a viability controller, we explicitly estimate the range of variations ofu for which the same controller gives viable solutions.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Annali di matematica pura ed applicata 160 (1991), S. 147-162 
    ISSN: 1618-1891
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary We study in this paper the initial value problem for the multivalued differential equation wheref is in MS(2) andG is a multifunction fromC([0, T];Ω) into the closed subsets of L2(0, Y;Ω), satisfying suitable regularity assumptions. As an application we prove a local existence result for the problem $$u\prime (t)2 - \partial ^ - f(u(t)) + G_1 (t,u(t)) + G_2 (t,u(t)),u(0) = u_0 ,$$ , where G1 (resp. G2) is a lower semicontinuous (resp. upper semicontinuous, convex valued) multifunction from [0, T]×Ω into H. No strong compactness is required for the values of G1 and G2. The differential inclusion (*) is also investigated in the case whereG comes from a multivalued regularization of g(t, x, u) and $$\int\limits_0^t {a(} t - s)g(s,;u(s))ds$$ , where g(t, x, u) is a discontinuous real single-valued function defined on [0, T]×Rn×R.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Neurological sciences 13 (1992), S. 53-58 
    ISSN: 1590-3478
    Keywords: Myotonic dystrophy ; cognitive function ; psychiatric diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Abbiamo valutato, in 40 pazienti affetti da forma severa di distrofia miotonica (MD), i disturbi cognitivi e i sintomi psichiatrici mediante test neuropsicologici (WAIS-R, MMSE) e mediante intervista semistrutturata e scala di autovalutazione (SADS, SRT). Come controllo abbiamo utilizzato 20 controlli sani. I pazienti con MD avevano punteggi significativamente più bassi di QI totale (p〈0.001), Verbale (p〈0.001) e non-Verbale (p〈0.001) del WAIS-R e al MMSE (p〈0.05) rispetto ai controlli. Il trentacinque per cento dei pazienti aveva una diagnosi psichica, di cui 17.5% avevano disturbi depressivi. I nostri dati confermano che i disturbi cognitivi e psichiatrici sono una manifestazione clinica importante nella distrofia miotonica.
    Notes: Abstract We evaluated 40 patients suffering from a severe form a myotonic dystrophy (MD) with neuropsychological (WAIS-R, MMSE) and psychiatric tests (SADS, SRT) for the assessment of cognitive and psychiatric symptoms. We tested 20 normal volunteers as control group. Patients with MD scored significantly, lower on WAIS Full Scale (p〈0.001), Verbal Scale (p〈0.001), and Performance Scale (p〈0.001) and on the MMSE (p〈0.05) than the controls. 35% of patients met the Research Diagnostic Criteria for a psychiatric diagnosis; 17.5% of them had a depressive disorder. The scores on SADS subscales and on the SRT scale of depression were also significantly higher in patients than in controls. Our data confirm that mental impairment and psychiatric disorders are important clinical manifestations of CNS dysfunction in the severe form on MD.
    Type of Medium: Electronic Resource
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