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  • Digitale Medien  (6)
  • 1990-1994  (5)
  • 1955-1959  (1)
Materialart
  • Digitale Medien  (6)
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  • 1
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 669 (1992), S. 0 
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Journal of cancer research and clinical oncology 116 (1990), S. 629-632 
    ISSN: 1432-1335
    Schlagwort(e): Methotrexate ; diarrhea ; Small intestine ; Prostaglandin ; rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Intraperitoneal administration of methotrexate in a single dose of 40 mg/kg induces fluid accumulation in the small intestine of rats, significantly increasing jejunal PGE2 formation and simultaneously the amounts of PGE2 in the intestinal contents in vivo. Concomitantly, jejunal PGD2 and 6-keto-PGF1α generation and the amounts of these prostaglandins in the intestinal contents were significantly lowered. However, PGD2 and 6-keto-PGFα jejunal release, and the amounts of these prostaglandins found in the intestinal contents, were already low after a subletal dose (4 mg/kg) of methotrexate, whereas the jejunal release as well as the amounts in the intestinal contents of PGE2 were not altered. Fluid accumulation, the amounts of prostaglandins in the intestinal contents and jejunal release of prostaglandins are siginificantly inhibited by indomethacin. The increased jejunal synthesis of PGE2, with its enteropooling effect, may play a significant role in methotrexate-induced diarrhea in rats.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Digestive diseases and sciences 35 (1990), S. 1468-1472 
    ISSN: 1573-2568
    Schlagwort(e): stomach ; human gastric mucosa ; muscarinic receptor subtype ; acid secretion ; glandular M3 receptor
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Five subtypes of muscarinic receptors have been distinguished by pharmacological and molecular biological methods. This report characterizes the muscarinic subtype present in human gastric mucosa by radioligand binding studies. The receptor density was 27 ±6 fmollmg protein and the tritiated ligand N-methylscopolamine had an affinity of (KD)0.39±0.08 nM (n=11). The M1 receptor selective antagonist pirenzepine and the M2 receptor selective ligand AF-DX 116 had low affinities of 148±32 nM (n=13) and 4043±1011 nM (n=3) KD,respectively. The glandular M3 antagonists hexahydrosiladifenidol and silahexocyclium had high affinities of KD 78±23 nM (n=5) and 5.6±1.8 nM (n=3). The agonist carbachol interacted with a single low-affinity site and binding was insensitive to modulation by guanine nucleotides. Antagonist and agonist binding studies thus showed an affinity profile typical of M3 receptors of the glandular type.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    ISSN: 1573-7357
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract The response of Superheated Superconducting Granule (SSG) devices to nuclear recoils has been explored by irradiating SSG detectors with a 70MeV neutron beam. In the past we have tested Al SSG and more recently, measurements have been performed with Sn and Zn detectors. The aim of the experiments was to test the sensitivity of SSG detectors to recoil energies down to a few keV. In this paper, the preliminary results of the neutron irradiation of a SSG detector made of Sn granules 15–20µm in diameter will be discussed. For the first time, recoil energy thresholds of ∼1keV have been measured.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    ISSN: 1573-7357
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract The presented results are part of a feasibility study of a Superheated Superconducting Granule (SSG) device for weakly interacting massive particles (WIMPs) detection. The sensitivity of SSG to nuclear recoils has been explored irradiating SSG detectors with a 70MeV neutron beam proving that energy thresholds of ∼1keV can be reached in 30µm Zn and 17µm Sn granules. The successful irradiation experiments with neutrons encouraged us to plan a prototype SSG dark matter detector. The status of the project will be presented and the expected counting rate for spin-independent WIMP interactions in SSG detectors will be discussed.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Springer
    Plant and soil 10 (1959), S. 356-374 
    ISSN: 1573-5036
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Summary The yield of phosphorus in sorghum plants grown on samples of 22 different soils from the United States was determined in the greenhouse. Analyses of variance of the regressions of these values on the measurements of soil phosphorus by various laboratory methods were calculated as an aid in evaluating the methods. No general advantage was found from incubating the samples in moist condition for a week before analysis versus making the analysis on the initially-dry samples. In the order of decreasing precision of predicting the yields of phosphorus the methods are as follows: (1) anion-exchange resin method of Amer and coworkers, (2) 0.5M NaHCO3 method of Olsen and coworkers, (3) phosphate potential method of Schofield and Aslyng, (4) phosphorus concentration in the 0.01M CaCl2 extract of Schofield and Aslyng, and (5) 0.1N HCl, 0.03N NH4F method of Bray and Kurtz. After taking into account the additional variables, little or no improvement in precision of prediction was obtained when the phosphorussorbedvs. time curves for the anion-exchange-resin method were (a) divided into four segments on the basis of time, the quantities of phosphorus in the four segments being used as independent variables in a multiple-regression equation, or (b) broken down into a maximum of four components on the assumption that the overall curve represents the summation of a group of simultaneous first-order reactions, the quantities of phosphorus in the several components being used as independent variables in a multiple-regression equation. The precision of prediction was improved by using as the soil-phosphorus measurement the sum of the products of the rate of phosphorus extraction by the anion-exchange-resin method and the quantities of phosphorus extracted within individual time intervals. A logarithmic expression was used to fit the relationship, however, and it appeared that the greater precision of prediction resulted from the logarithmic transformation rather than the superiority of the method as such. The precision of prediction was improved also by using the H2PO 4 − concentration instead of the total-inorganic-phosphorus concentration as the independent variable in the 0.01M CaCl2 extracts of Schofield and Aslyng and by using the H2PO 4 − instead of the total inorganic phosphorus sorbed by the anion-exchange resin. This modification made the anion-exchange-resin method considerably better than the others tested.
    Materialart: Digitale Medien
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