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  • 1
    Electronic Resource
    Electronic Resource
    Mechanisms of Thermolytic Rearrangement of cis-Bis(silylmethyl)platinum(II) Complexes: .beta.-Carbon Transfer Predominates over Hydrogen Transfer (1994)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 116 (1994), S. 9963-9978 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00101a018
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  • 2
    Electronic Resource
    Electronic Resource
    Arteether-induced brain injury in Macaca mulatta. I. The precerebellar nuclei: the lateral reticular nuclei, paramedian reticular nuclei, and perihypoglossal nuclei (2000)
    Springer
    Anatomy and embryology 201 (2000), S. 383-397 
    Details
    ISSN: 1432-0568
    Keywords: Key words Lateral reticular nuclei ; Paramedian reticular nuclei ; Perihypoglossal nuclei ; Malaria ; Arteether ; Artemisinin ; Neurotoxicity ; Rhesus monkey ; Antimalarial drugs ; Cerebral malaria ; Macaca mulatta ; Plasmodium falciparum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Malaria poses a threat across several continents: Eurasia (Asia and parts of Eastern Europe), Africa, Central and South America. Bradley (1991) estimates human exposure at 2,073,000,000 with infection rates at 270,000,000, illnesses at 110,000,000, and deaths at 1,000,000. Significant mortality rates are attributed to infection by the parasite Plasmodium falciparum, with an estimated 90% among African children. A worldwide effort is ongoing to chemically and pharmacologically characterize a class of artemisinin compounds that might be promising antimalarial drugs. The U.S. Army is studying the efficacy and toxicity of several artemisinin semi-synthetic compounds: arteether, artemether, artelinic acid, and artesunate. The World Health Organization and the U.S. Army selected arteether for drug development and possible use in the emergency therapy of acute, severe malaria. Male Rhesus monkeys (Macaca mulatta) were administered different daily doses of arteether, or the vehicle alone (sesame oil), for a period of either 14 days, or 7 days. Neuropathological lesions were found in 14-day arteether treated monkeys in the precerebellar nuclei of the medulla oblongata, namely: (1) the lateral reticular nuclei (subnuclei magnocellularis, parvicellularis, and subtrigeminalis), (2) the paramedian reticular nuclei (subnuclei accessorius, dorsalis, and ventralis), and the perihypoglossal nuclei (n. intercalatus of Staderini, n. of Roller, and n. prepositus hypoglossi). The data demonstrate that the simian medullary precerebellar nuclei have a high degree of vulnerability when arteether is given for 14 days at dose levels between 8 mg/kg per day and 24 mg/kg per day. The neurological consequences of this treatment regimen could profoundly impair posture, gait, and autonomic regulation, while eye movement disorders might also be anticipated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004290050326
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  • 3
    Electronic Resource
    Electronic Resource
    Therapeutic ERCP: Spectrum of procedures performed in 60 consecutive patients (1994)
    Springer
    Abdominal imaging 19 (1994), S. 30-33 
    Details
    ISSN: 1432-0509
    Keywords: Biliary tract, obstruction ; Gallstone, diagnosis ; ERCP, interventional techniques
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Therapeutic applications of endoscopic retrograde cholangiopancreatography (ERCP) have increased dramatically, and endoscopic sphincterotomy (ES) is the cornerstone of these techniques. Indications include treatment of retained biliary duct stones, papillary stenosis, benign and malignant strictures, and acute cholangitis and pancreatitis. We reviewed our recent experience to assess the spectrum of procedures done and their results. Medical records and radiographic examinations in 60 consecutive patients undergoing therapeutic ERCP were studied. Patients were placed into one of three treatment groups; Group 1, ES alone (N=21); Group 2, ES plus stone retrieval (N=15); and Group 3, ES plus stent placement (N=24). In Group 1, all of eight patients with ductal stones had spontaneous passage. In 11 patients with papillary stenosis, nine had relief of symptoms following ES. Two patients with pancreatitis improved after ES. In Group 2, all 15 patients with ductal stones had successful retrieval. In Group 3, patients were treated for biliary stricture alone (4), retained stones (7), pancreatitis (5), neoplasms (6) and papillary stenosis (2). In these 24 patient, 21 (88%) were treated successfully or had palliation of their symptoms. In our series, a wide variety of therapeutic applications of ERCP was used to manage simple and complex biliary disease. ES alone or in combination with other techniques was done in all patients. Overall, 55 (92%) of 60 interventional procedures were successful as defined by removal of stones and relief or palliation of symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02165857
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  • 4
    Electronic Resource
    Electronic Resource
    Relativistic Heavy ION Physics at Cern and BNL (1992)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Nuclear and Particle Science 42 (1992), S. 537-597 
    Details
    ISSN: 0163-8998
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ns.42.120192.002541
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  • 5
    Electronic Resource
    Electronic Resource
    Histopathology, blood chemistry, and physiological status of normal and moribund striped bass (Morone saxatilis) involved in summer mortality (’die-off‘) in the Sacramento-San Joaquin Delta of California (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 44 (1994), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Summer mortality (’die-off‘) is common in striped bass, Morone saxatilis (Walbaum), in the San Francisco Bay-Delta region. Tissue and blood samples of moribund and healthy striped bass collected during the summers of 1986–1988 were analysed. Sixteen moribund and 25 healthy reference fish from the Carquinez Strait area and eight fish caught in the Pacific Ocean were studied. Moribund fish plasma was invariably yellow-orange; most of the moribund fish had discoloured livers with haemorrhagic regions, and approximately one-third had haemorrhagic intestines. Piasma levels of aspartale aminotransferase, uric acid, alkaline phosphatase and cortisol were significantly higher than in reference fish from Carquinez Strait and the Pacific Ocean, whereas cholesterol, sodium, chloride, triiodothyronine and glucose levels were significantly lower. Hepatic heavy metal concentrations and bacterial content were similar in moribund and reference fish. Gill Na.+, K+ -ATPase activity was significantly lower in moribund fish. Liver, kidney, intestine, and thyroid follicles of moribund fish displayed various histopathological changes, and corticosteroidogenic (interrenal) tissue could not be identified positively in moribund fish. These findings are discussed in relation to recent work on the chemical burdens (industrial and agricultural hydrocarbons) found in livers from some of the fish examined in this study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1994.tb01229.x
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  • 6
    Electronic Resource
    Electronic Resource
    Mechanistic studies of the thermolytic and photolytic rearrangement of [bis(diphenylphosphino)ethane]bis(neophyl)platinum(II) (1992)
    s.l. : American Chemical Society
    Organometallics 11 (1992), S. 2591-2598 
    Details
    ISSN: 1520-6041
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/om00043a049
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  • 7
    Electronic Resource
    Electronic Resource
    Induction of annual cyclical changes in the ichthyofauna of a large microtidal estuary following an artificial and permanent increase in tidal flow (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of fish biology 63 (2003), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The opening of a deep artificial and second entrance channel into the large Peel-Harvey Estuary in south-western Australia in 1994 provided a unique opportunity to determine the characteristics of the ichthyofauna of a microtidal estuary, in which tidal water movement and the rate of recovery of salinities in spring have both increased markedly. Fishes in the original entrance channel and both halves of the two large basins (Peel Inlet and Harvey Estuary), which constitute most of the total area of the estuary, were sampled using a 21·5 m long seine with a fine (3 mm) mesh bunt. The 72 337 fishes that were caught throughout the estuary and represented 43 species, comprised mainly marine species, both in terms of number of species (65·1%) and number of individuals (70·6%). The number of species and density of fishes in each region, and particularly in the basins, showed a pronounced tendency to decline from a maxima in summer to a minima in winter and then to rise in spring. Although the species composition of the fish fauna in the natural entrance channel differed significantly from that in each of the four basin regions, those within the basins were significantly different only in the cases of the southern Harvey Estuary versus both regions of the Peel Inlet. Species composition in the natural entrance channel and four basin regions each underwent conspicuous cyclical changes during the year, which reflected out-of-phase changes in the densities of certain species. Although this cyclical pattern was due mainly to changes in the densities of marine species, it was augmented by those of estuarine residents. The cyclicity, which was not evident prior to the opening of the artificial Dawesville Channel, and thus when tidal water movement within the estuary was far less pronounced, parallels the situation recorded for macrotidal northern hemisphere estuaries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1095-8649.2003.00253.x
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  • 8
    Electronic Resource
    Electronic Resource
    Painless urethral bleeding: an unusual presentation of Von Willebrand disease (2003)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 9 (2003), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  Von Willebrand disease (vWD) is the most common bleeding disorder, and usually presents with either easy bruising or mucus membrane bleeding. Many patients are also diagnosed as a result of abnormal pre-operative laboratory tests. In this report, we describe two patients presenting with painless, persistent urethral bleeding as their initial manifestation of vWD. The first patient began bleeding after a Foley catheter was placed during a hospital admission for status epilepticus. A urologic examination demonstrated a wound in the posterior urethra. Despite repeated attempts at controlling the bleeding with cautery, the bleeding persisted. The second patient presented with spontaneous urethral bleeding and a normal urologic examination. Due to persistent bleeding, both patients underwent a coagulation evaluation that demonstrated the presence of type 1 vWD. The first patient had resolution of his bleeding following 5 weeks of Alphanate, a von Willebrand factor containing factor VIII concentrate, and aminocaproic acid. The second patient initially responded to desmopressin, but subsequently required Humate-P to achieve complete resolution. These cases illustrate the importance of an evaluation for bleeding disorders in patients with persistent bleeding from any site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2516.2003.00749.x
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  • 9
    Electronic Resource
    Electronic Resource
    Current therapy for rare factor deficiencies (2001)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 7 (2001), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Haemophilia A and B and von Willebrand disease account for 80–85% of all inherited bleeding disorders. The other 15% are represented by deficiencies of fibrinogen, prothrombin, or factors V, VII, X, XI, or XIII. In addition, acquired factor deficiencies are seen in a variety of conditions ranging from malignancies to autoimmune disorders. The spectrum of symptoms in these conditions varies from severe and life-threatening haemorrhage to a mild bleeding diathesis. The diagnosis depends on demonstration of decreased activity of one of the clotting factors. Due to the rarity of each of the individual factor deficiencies, purified factor concentrates are not as readily available as they are for haemophilia A and B. Treatment of rare clotting factor deficiencies consists of the most purified blood product available that contains the missing factor. Depending on which factor is deficient, either purified concentrates, prothrombin complex concentrates, cryoprecipitate, or fresh frozen plasma can be used. In addition, recombinant factor VIIa is available for treating factor VII deficient patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2516.2001.00100.x
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  • 10
    Electronic Resource
    Electronic Resource
    Sequential therapy with activated prothrombin complex concentrate and recombinant factor VIIa in patients with severe haemophilia and inhibitors (2004)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 10 (2004), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  Patients with haemophilia and inhibitors have bleeding episodes that can be refractory to home therapy with either activated prothrombin complex concentrate (APCC) or recombinant factor VIIa (rFVIIa). Sequential therapy with these products has not been widely used because of concern regarding the possibility of thrombosis. This report describes the results of a retrospective chart review of five hospitalized children with severe haemophilia and inhibitors who have been treated with sequential doses of APCC and rFVIIa for refractory bleeding. These patients all had failed home therapy with APCC and rFVIIa alone. A total of 20 admissions were documented covering 170 hospital days, including 91 days of combination therapy. While being closely monitored in the hospital, they received alternating doses of APCC and rFVIIa every 6 h. Anywhere from one to three doses of rFVIIa were given every 2 h between APCC doses. Doses of APCC ranged from 35 to 80 U kg−1 dose−1, and doses of rFVIIa ranged from 80 to 225 mcg kg−1 dose−1. There was no clinical or laboratory evidence of thrombosis, thrombocytopenia, or disseminated intravascular coagulation (DIC). We found the combination of these factors to be safe and effective for patients with refractory bleeds. However, we recommend this aggressive therapy only in the inpatient setting with careful monitoring of the physical examination and frequent laboratory screening to assess for thrombosis and DIC, and without the concurrent use of antifibrinolytic medications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2516.2004.00912.x
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