ISSN:
1435-1536
Schlagwort(e):
Liposomes
;
adsorption
;
spreading
;
surfacefilm
;
monolayer
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
,
Maschinenbau
Notizen:
Abstract Liposomes from pure dipalmitoylphosphatidylcholine (DPPC) and mixed DPPC: distearoylphosphatidylcholine (DSPC): soybean lecithin (SL) prepared by the Bangham method with sonication were dispersed into solution or spread at the interface and the kinetics of the surface film formation was studied by measuring and recording the evolution of superficial tension, surface potential, and superficial (14C labeled) DPPC density. A simple theoretical approach can describe these kinetics by two processes: irreversible diffusion of closed vesicles into or from the bulk phase, and irrevers ible transformation of closed spherical vesicles into destroyed ones which form the surface film. Diffusion controls the phenomenon for small initial amounts of liposomes. Transformation controls the phenomenon for important initial amounts of liposomes. The kinetic constant of the transformation,K, does not depend on the technique used to form the surface film (spreading or adsorption). The equilibrium and rheological properties of surface films formed after liposome spreading are compared to those of monolayers
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00657735
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