Bibliothek

X
feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
  • 1
    Digitale Medien
    Digitale Medien
    A longitudinal study of bacterial vaginosis during pregnancy (1994)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 101 (1994), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Objective To determine the longitudinal changes in the incidence of bacterial vaginosis in pregnancy.Design A prospective study of women during pregnancy.Setting A District General Hospital in North-West London.Subject Seven hundred and eighteen pregnant women attending antenatal clinics. At their first attendance and subsequently, Gram-stained vaginal smears were examined and Mycoplasma hominis and Gardnerella vaginalis were sought by culture.Results Initially, 87 (12%) women had bacterial vaginosis diagnosed on Gram-stained reading of the vaginal smears. Examination of further smears, obtained from 176 women at 36 weeks of gestation, showed that those whose vaginal flora was normal initially, and who went to term, rarely developed vaginosis (three of 127, 2.4%). Samples were obtained at 36 weeks gestation from 32 women who had bacterial vaginosis initially, and went to term. In almost 50% (15 of 32) of these a normal lactobacillus-dominated flora had regenerated. Thirty-five women (5%) had initial vaginal smears graded as intermediate. From this group, six of the 17 (35%) women from whom samples were obtained at 36 weeks gestation still had flora of an intermediate pattern; 10 (59%) now had normal flora and only one (6%) had developed bacterial vaginosis. Women with bacterial vaginosis were more likely to be culture-positive for M. hominis than those with normal flora (34/78 versus 10/563, odds ratio 42.73 (18.9 to 102.3) P 〈 0.001), or to be culture-positive for G. vaginalis than those with normal flora (35/78 versus 21/563, odds ratio 21.0 (10.75 to 41.2) P 〈 0.001).Conclusion Pregnant women do not commonly develop bacterial vaginosis after 16 weeks gestation, and if present, it remits spontaneously in approximately half of those who reach term. As bacterial vaginosis is associated with increased rates of second trimester miscarriage and preterm delivery, any treatment aimed at its eradication in pregnancy should be given no later than the beginning of the second trimester of pregnancy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1994.tb13580.x
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 2
    Digitale Medien
    Digitale Medien
    Effect of cholera toxin on the induction of gamma-glutamyl transpeptidase-positive clones by benzo(a)pyrene in embryonic mouse tongue cells in culture (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 15 (1986), S. 0 
    Details
    ISSN: 1600-0714
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract The utility of gamma-glutamyl transpeptidase (GOT) as a histochemical marker to study the carcinogen-induced changes and its possible modulation by cholera toxin was explored in primary cell cultures. It was observed that cholera toxin not only promotes growth of fibroblasts in primary cell culture, but it also enhances the GGT-positive foci induced by benzo(a)pyrene. It is interesting to speculate that cholera toxin may be acting as a tumor promoter in primary cell cultures of embryonic mouse tongue.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0714.1986.tb00607.x
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    Experimental studies on mutagenic and carcinogenic effects of tobacco chewing (1985)
    Springer
    Journal of cancer research and clinical oncology 109 (1985), S. 203-207 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Chewing tobacco ; Nitrosamine ; Oral cancer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The alcoholic extract of the chewing (Pandharpuri) variety of tobacco (Nicotiana tabaccum) was subjected to mutagenicity and tumorigenicity studies. The extract was found to be mutagenic in strain TA 98 of Salmonella typhimurium in the presence of S 9 mixture. It also induced 8 AZG-resistant mutation in V 79 Chinese hamster cells. Administration of tobacco extract to male Swiss mice by gavage or mixed with diet resulted in an increased incidence of lung/liver tumors. Further, an additive effect of tobacco extract and hexachlorocyclohexane on liver tumor induction was observed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00390358
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 4
    Digitale Medien
    Digitale Medien
    Carcinogenicity, perinatal carcinogenicity and teratogenicity of low dose metronidazole (MNZ) in Swiss mice (1986)
    Springer
    Journal of cancer research and clinical oncology 112 (1986), S. 135-140 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Metronidazole ; Carcinogenicity ; Teratogenicity ; Perinatal carcinogenicity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Metronidazole (MNZ), a widely used therapeutic drug, was administered to male and female Swiss mice intragastrically at a dose of 2 mg MNZ/mouse per day, 5 days a week, every alternate week, throughout their life span to test its carcinogenicity. The treatment induced a significant increase in the overall incidence of tumors in female mice but not in male mice. At the same dose, no teratogenic effect was observed. Perinatal carcinogenicity was studied by following up animals till the end of the F2 generation. Though different groups of animals were considered, a significant increase in tumor incidence was observed only in F1 mice which received MNZ treatment during gestation as compared to the corresponding control mice which received distilled water. The F1 mice which received MNZ during gestation, lactation, and subsequently in adulthood, and the F2 progeny had a tumor incidence comparable to that observed in control mice.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00404396
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 5
    Digitale Medien
    Digitale Medien
    Catechin as an antimutagen: its mode of action (1988)
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 177-182 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Catechin ; Acacta catechu ; Cyanidoanol-3 ; Betel quid
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In the present study, we report that the betel quid ingredient catechu, its extract and pure principle catechin were nonmutagenic in Salmonella typhimurium TA 100, TA 1535, TA 98, and TA 1538 assays with or without metabolic activation. They also exhibited dose-dependent decreases in mutagenicity of benzo(a)pyrene [B(a)P] and dimethylbenz(a)anthracene (DMBA) in strain TA 98 with metabolic activation. We further report that these compound inhibited activites of cytochrome P-450 and had no effect on glutathione S-transferase but increased the glutathione content in rat liver tissue. Simultaneous treatment of catechin prevented the mutagenic activity of B(a)P and DMBA metabolites in strain TA 98 in the absence of metabolic activation. Pre-and posttreatment of bacteria with catechin had no effect on the mutagenicity of B(a)P and DMBA metabolites. Catechin also inhibited the in vitro binding of 3H-B(a)P metabolites to calf thymus DNA. Catechu extract and catechin inhibited the nitrosation of methylurea by nitrite at pH 3.6 and 30°C. The formation of nitrosomethylurea in the reaction mixture was monitored by measuring the histidine revertants of strain TA 1535 in the absence of metabolic activation. Pre-and post-treatment of catechu extract or catechin had no effect on the mutagenicity of nitrosomethylurea in TA 1535. The nitrosation inhibition by catechin was through scavenging of nitrite observed at pH 3.6. The above study indicates that catechu in betel quid may act as an antimutagen and may suppress the mutagenic potential of other betel quid mutagens.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00417833
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 6
    Digitale Medien
    Digitale Medien
    Carcinogenicity of Indian bidi and cigarette smoke condensate in Swiss albino mice (1988)
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 647-649 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Indian bidi and cigarette smoke condensate ; Polycyclic aromatic hydrocarbon ; Careinogenicity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The carcinogenicity of Indian bidi and cigarette smoke condensate given by gavage was studied in Swiss mice. Bidi smoke condensate induced liver haemangiomas in four animals, forestomach papilloma in one animal and carinomas in two animals, in one of them was in the oesophagus and in the other in the forestomach. At the same dose level cigarette smoke condensate failed to produce any tumour. Similarly, none of the untreated and solvent-treated control mice developed tumour. Chemical analysis of the smoke concensate of bidis and cigarettes showed that condensate from bidis had a higher benzo[a]pyrene level than was observed in cigarette smoke condensate, when compared on the basis of the mass (mg) burnt.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00398193
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 7
    Digitale Medien
    Digitale Medien
    Effects of tobacco-specific nitrosamines and snuff extract on cell proliferation and activities of ornithine decarboxylase and aryl hydrocarbon hydroxylase in mouse tongue primary epithelial cell cultures (1989)
    Springer
    Journal of cancer research and clinical oncology 115 (1989), S. 558-563 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Tobacco-specific nitrosamines ; Snuff ; Ornithine decarboxylase ; Aryl hydrocarbon hydroxylase ; Oral carcinogenesis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Tobacco and its related compounds, including snuff, have been implicated in oral cancers. Tobacco-specific nitrosamines have been shown to be the causative agents present in tobacco and its related compounds. Both, N-nitrosonornicotine (NNN) and its butanone derivative (NNK) are carcinogenic in animals. In our in vitro studies using embryonic mouse tongue epithelial cells, NNN is linked to an increase in [3H]dT uptake along with a concomitant increase in ornithine decarboxylase and aryl hydrocarbon hydroxylase activities. NNK, the more potent compared to NNN, causes a further increase in [3H]dT uptake, cell count and ornithine decarboxylase activity. However, aryl hydrocarbon hydroxylase behaves differently in cultures treated with NNK compared to those treated with NNN. Snuff extract has an overall inhibitory effect on cell count, [3H]dT uptake, and ornithine decarboxylase and aryl hydrocarbon hydroxylase activities when administered either alone or in combination with NNN and NNK. How the inhibitory effect of snuff in the presence of tobacco-specific nitrosamines is involved in oral carcinogenesis should be further investigated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00391358
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 8
    Digitale Medien
    Digitale Medien
    Carcinogenicity studies of masheri: pyrolysed tobacco product, in vitamin-A-deficient sprague dawley rats (1991)
    Springer
    Journal of cancer research and clinical oncology 117 (1991), S. 50-54 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Vitamin A deficiency ; Masheri ; Tumorigenicity ; Mixed-function oxygenases
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The carcinogenicity of long-term feeding of masheri extract to animals in a vitamin-A-sufficient (SLO+) and deficient (SLO−) state was studied in Sprague Dawley rats by feeding daily dose of 3 mg extract over a period of 21 mounths. The phase I activating enzymes, the glutathione (GSH)/glutathione S-transferase (GST) detoxification system, and the hepatic and circulating levels of vitamins A and C were also monitored at 12 and 21 months. It was observed that the phase I enzyme activities were significantly higher in SLO+ than in SLO− rats at both 12 months and 21 months. Moreover, the SLO− masheri-treated animals also showed a decreased in the GSH/GST detoxification system while the reverse was observed in SLO+ group. Masheri extract treatment significantly lowered the hepatic and circulating levels of vitamin A while a concurrent increase was observed in the vitamin C level. The extract was found to be tumorigenic in both the SLO+ and SLO− groups. Benign tumours were observed in the SLO+ group while a high incidence of malignant tumours of the lung were observed in the SLO− group upon treatment with masheri extract.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01613196
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 9
    Digitale Medien
    Digitale Medien
    Protective role of aqueous turmeric extract against mutagenicity of direct-acting carcinogens as well as Benzo[a]pyrene-induced genotoxicity and carcinogenicity (1992)
    Springer
    Journal of cancer research and clinical oncology 118 (1992), S. 447-452 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Antimutagenicity ; Benzo[a]pyrene ; Chemoprevention ; Turmeric extract
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Turmeric (Curcuma longa Linn.) has been shown to inhibit chemical carcinogenesis. In this study, we compared the chemopreventive efficacy of an aqueous turmeric extract (AqTE) and its constituents, curcumin-free aqueous turmeric extract (CFAqTE) and curcumin, using theSalmonella typhimurium mutagenicity assay and the bone marrow micronucleus test in female Swiss mice. AqTE exhibited antimutagenic activity against direct-acting mutagens, 4-nitro-O-phenylenediamine and 1-methyl-3-nitro-1-nitrosoguanidine, in strains TA 98 and TA 100 respectively. Both AqTE and CFAqTE inhibited the mutagenicity of benzo[a]pyrene in the two strains in the presence of Aroclor-1254-induced rat liver homogenate. The inhibition in both studies was dose-dependent. Administration of AqTE, CFAqTE and curcumin at a dose of 3 mg/animal 18 h prior to i.p. benzo[a]-pyrene injection (250 mg/kg) significantly inhibited bone marrow micronuclei formation in female Swiss mice by 43%, 76%, and 65% respectively. Furthermore, the incidence and multiplicity of forestomach tumours induced by benzo[a]pyrene (1 mg/animal, twice weekly, p.o. for 4 weeks) in female Swiss mice were significantly inhibited by AqTE, CFAqTE and curcumin given 2 weeks before, during and after the carcinogen treatment. These data indicate that the protection against genomic damage by turmeric extract and its components tested could be necessary for some aspects of its cancer chemoprevention.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01629428
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 10
    Digitale Medien
    Digitale Medien
    Species differences in hepatic pulmonary and upper gastrointestinal tract biotransformation enzymes on long-term feeding of masheri—A pyrolyzed tobacco product (1991)
    Springer
    Digestive diseases and sciences 36 (1991), S. 293-298 
    Details
    ISSN: 1573-2568
    Schlagwort(e): drug metabolizing enzymes ; rodent species ; masheri ; gastrointestinal tract ; lung ; liver
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The activities of several activating enzymes and that of glutathioneS-transferase as well as levels of glutathione were measured in the upper alimentary tract, lung, and liver of Swiss mice, Sprague-Dawley rats, and Syrian golden hamsters treated with 10% masheri (pyrolyzed tobacco) in diet for 20 months. Significant increase in activities of phase I activating enzymes and a remarkable decrease in the phase II detoxification system in most extrahepatic tissues of the treated animals of all three species was observed. These observations suggest that the prolonged exposure to environmental xenobiotics/carcinogens affects the drug-metabolizing enzymes of the gastrointestinal tract, which may be an important factor in determining the susceptibility of different organs to carcinogen exposure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01318199
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...