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  • 1990-1994  (6)
  • 1965-1969  (1)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Personnel psychology 19 (1966), S. 0 
    ISSN: 1744-6570
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Psychology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 33 (1991), S. 167-169 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of histamine H3-receptors in the control of acetylcholine release from peripheral cholinergic neurons was evaluated in the isolated guinea pig ileum, previously loaded with3H-choline. When tested in the presence of H1- and H2-blockade, histamine (0.1–100 μmol/l) and (R)α-methylhistamine (0.01–1 μmol/l) dose-dependently reduced the electrically-evoked choline outflow, with (R)α-methylhistamine being a partial agonist. Selective H3-receptor blocking drugs, thioperamide (0.1 μmol/l) and impromidine (0.1 μmol/l) reversed the histamine-induced inhibitory, effect. These data suggest that intestinal cholinergic nerves are endowed with histamine H3-receptors whose activation produces an inhibitory effect upon acetylcholine release. The practical implications of these findings are obvious.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1420-9039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric nephrology 5 (1991), S. 673-673 
    ISSN: 1432-198X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Histochemistry and cell biology 101 (1994), S. 41-49 
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Alpha 6 integrin is an adhesion molecule that connects cells with extracellular matrix molecules of the laminin family. The laminin interaction seems to be essential for cell differentiation during embryogenesis and for the subsequent maintenance of tissue integrity in the adult. Alpha 6 integrin can also interact with laminin-independent cellular ligands and in this way plays a role in homing of leucocytes. Furthermore, in cancer biology α6 integrin has an important role in metastasis and as a possible new prognostic factor; exact knowledge of α6 integrin distribution in normal human tissues is therefore a crucial element. By immuno-histochemical methods we have screened α6 integrin expression of representative human tissues from the adult and the embryonic organism. All tested epithelia were α6 integrin positive, except for the endocrine cells of the pancreas and the adrenal glands. Heterogeneous staining was found on non-epithelial tissues. Strong staining was evident in peripheral nerves (Schwann cells), germ and Sertoli cells, endothelia, and smooth muscle cells of the myometrium. Weak staining was found in nerve cells of the stratum granulosum, the microglia, Kupffer's cells and stromal cells of the ovary. All fibroblasts, striated muscle cells and astrocytes were negative. The tissue distribution of α6 integrin and the semi-quantitative estimation of their expression level should provide a better understanding of α6 integrin function under normal and phathological conditions, in particular in tumour progression.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract CD44 is a transmembrane glycoprotein, which can exist in a multitude of isoforms due to alternative splicing of the pre-mRNA. We have generated monoclonal antibodies to several of these variant regions, which are encoded by 10 additional exons in the extracellular part of the molecule. CD44 variant isoforms have been reported to be involved in the malignant progression of rat and human tumours. The precise localization of CD44 variant isoforms in normal developmental and morphogenetic processes is essential for diagnostic studies of human tumorigenesis. Therefore, we have analysed a large number of different human tissues by immunohistochemistry for the expression of CD44 isoforms containing either exons 4v, 6v or 9v. Expression of exon 9v-isoforms was detected in almost all epithelia analysed, with a few exceptions. Exon 6v isoforms are expressed only in squamous and glandular epithelia, e.g. skin epidermis, sweat and sebaceous glands, oesophagus, ducts of the mammary gland, salivary and prostate glands. Detection of exon 4v-encoded isoforms was restricted to the epidermis and the oesophagus. Similar tissue distributions of CD44 variant isoforms were observed in 10-week-old fetal tissues. Since one of the ligands of CD44 is hyaluronic acid (HA), we also analysed the tissue distribution of HA synthetase. HA synthetase was detected in all tissues analysed, showing good correlation with the expression of the standard form of CD44, CD44s.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International journal of fracture 44 (1990), S. 179-188 
    ISSN: 1573-2673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Résumé Les auteurs ont précédemment proposé une méthode pratique d'utilisation de petits cylindres avec entaille circonférentielle et fissure de fatigue pour mesurer K 1c. A fond de l'entaille usinée en Vé, on crée une fissure de fatigue par flexion rotative. L'éprouvette est ensuite rompue en traction et le K 1c en est déduit. En pratique, cependant, une proportion significative des ligaments demeurant après fissuration par fatigue est excentrée, et parfois la zone non fissurée n'est pas circulaire. On a procédé à une analyse par éléments finis sur une gamme de tailles et d'excentricités de ligaments, en vue d'établir une relation permettant de déterminer K 1c à partir d'éprouvettes présentant de telles excentricités. Les résultats utilisant cette relation sont comparés aux données d'expériences.
    Notes: Abstract The authors have earlier proposed a practical method of using a small cylindrical circumferentially notched and fatigue cracked specimen to measure K 1c. This specimen has a machined “Vee” groove, from the root of which, is grown a fatigue crack using rotating bending. This specimen is then broken in tension and K 1c thus established. In practice however a significant proportion of the final ligaments after fatigue cracking are eccentric and some are non-circular. Finite element analysis has been carried out on a spectrum of final ligament sizes and eccentricities, leading to a relationship for determining K 1c from such eccentrically cracked specimens. The results using this relationship are compared with experimental data.
    Type of Medium: Electronic Resource
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