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Digitale Medien

PET studies with l-[1-11C]tyrosine, l-[methyl-11C]methionine and 18F-fluorodeoxyglucose in prolactinomas in relation to bromocryptine treatment (1991)

Daemen, Bernard J. G. ; Zwertbroek, Rolf ; Elsinga, Philip H. ; [weitere]

Springer

European journal of nuclear medicine 18 (1991), S. 453-460

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ISSN: 1619-7089

Schlagwort(e): Positron emission tomography ; 11C-amino acids ; 18F-fluorodeoxyglucose ; Prolactinoma ; Salivary gland

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Aspects of metabolism in prolactinomas were investigated by positron emission tomography using l-[1-11C]tyrosine, l-[methyl-11C]methionine and 18F-fluorodeoxyglucose (18FDG). Using l-[1-11C]tyrosine, four patients were monitored prior to and 18 h after an injection of 50 mg bromocryptine. At 18 h after bromocryptine intervention, l-[1-11C]tyrosine uptake into tumour was reduced with 28% (P〈0.07). A correlation analysis of the bromocryptine-induced decrease in l-[1-11C]tyrosine uptake and the reduction of serum prolactin levels indicated that the action of bromocryptine on prolactin synthesis and prolactin release is not coupled. In the untreated situation, the four patients were investigated with 18FDG as well, but the prolactinomas could not be visualized. Three untreated patients were studied with l-[methyl-11C]methionine. The tumour-imaging potential of l-[methyl-11C]methionine and l-[1-11C]tyrosine appeared to be nearly equivalent for prolactinomas. Unlike prolactinoma tissue, the salivary glands showed a pronounced preference for l-[1-11C]tyrosine as compared to l-[methyl-11C]methionine. l-[1-11C]tyrosine is a valuable tool to obtain information on the metabolism and treatment of prolactinomas.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00181283

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Digitale Medien

Raman spectroscopic study of the effect of take-up speed on conformation, orientation, and crystallinity in PET fibers (1990)

Bulkin, Bernard J. ; Deblase, Frank J. ; Lewin, Menachem

New York, NY : Wiley-Blackwell

Polymers for Advanced Technologies 1 (1990), S. 133-142

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ISSN: 1042-7147

Schlagwort(e): Raman spectrum ; Crystallinity ; Conformation ; PET fibers ; Chemistry ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie , Maschinenbau

Notizen: The dependence of the Raman spectrum of PET fibers on take-up speed (TUS) during high-speed spinning is examined. It is found that conformational change, orientation, and crystallinity, all different functions of TUS as a processing variable, are reflected in the spectra. The data, as well as those from thermal annealing of PET fibers, are shown to be consistent with those from other techniques, leading to a set of equations from which a number of properties of the PET fibers can be determined from the Raman spectrum alone.

Zusätzliches Material: 9 Ill.