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Digitale Medien

Modeling analysis of an intercalated-spiral alternate-dead-ended hollow fiber bioreactor for mammalian cell cultures (1990)

Brotherton, John D. ; Chau, Pao C.

New York, NY [u.a.] : Wiley-Blackwell

Biotechnology and Bioengineering 35 (1990), S. 375-394

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Details

ISSN: 0006-3592

Schlagwort(e): Chemistry ; Biochemistry and Biotechnology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: The model analysis of a bioreactor with two intercalated-spiral sets of hollow fibers with alternated dead ends is presented. Design equations are derived based on a model with two jumped fibers and an approximation of the fluid mechanics with a small fiber radius-to-length ratio. The performance of the bioreactor is simulated with and without cell growth utilizing a segregated radial flow model in the extracapillary space. The pressure modulus, the wall Peclet number, the Thiele modulus, and the Monod constant are used as model parameters. The results can be used to assess the proper choice of fiber permeability, fiber length, fiber spacing, and flow velocity.

Zusätzliches Material: 15 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bit.260350406

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