ISSN:
1435-1463
Schlagwort(e):
Lithium
;
imipramine
;
desipramine
;
tranylcypromine
;
5-HT1A receptors
;
adenylate cyclase
;
hippocampus
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary In order to determine the relevance of 5-HT1A-related signal transduction in the mode of action of lithium and antidepressants, the effects of long-term treatment with these drugs on the 5-HT1A-mediated inhibition of forskolin-stimulated adenylate cyclase activity were investigated in the rat hippocampal membranes. Chronic administration of antidepressants altered neither the [3H]8-hydroxy-2-(di-n-propylamino)tetralin ([3H]8-OH-DPAT) binding sites nor the inhibition of forskolin-stimulated adenylate cyclase activity by 5-HT. Long-term treatment with lithium did not affect the inhibitory effect of 5-HT on the forskolin-stimulated adenylate cyclase activity, either. Neither the stimulation by forskolin nor the inhibition by guanyl-5′-ylimidodiphosphate (Gpp(NH)p) of adenylate cyclase activity was not influenced by lithium treatment, suggesting that lithium has no effects on the components of adenylate cyclase system distal to the 5-HT1A receptors. These results indicate that the 5-HT1A-mediated neural transmission has not such an important relevance in the mechanisms of action of lithium or antidepressants.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01250570
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