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  • 1
    Electronic Resource
    Electronic Resource
    Gramicidin channels that have no tryptophan residues (1992)
    s.l. : American Chemical Society
    Biochemistry 31 (1992), S. 5340-5350 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00138a014
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of acylation on the channel characteristics of gramicidin A (1992)
    s.l. : American Chemical Society
    Biochemistry 31 (1992), S. 7320-7324 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00147a016
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  • 3
    Electronic Resource
    Electronic Resource
    A nationwide population-based study of the familial aggregation of Type 1 (insulin-dependent) diabetes mellitus in Denmark (1993)
    Springer
    Diabetologia 36 (1993), S. 870-875 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 (insulin-dependent) diabetes mellitus ; nationwide population-based ; familial prevalence ; sporadic cases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The objective of the present study was to assess the prevalence of familial aggregation of Type 1 (insulin-dependent) diabetes mellitus among Danish families with a diabetic child aged 20 years or less and to compare epidemiological data for familial and sporadic cases. We attempted to identify all patients with Type 1 diabetes aged 0–19 years in Denmark treated at paediatric departments or at departments of internal medicine. This comprises more than 98% of all patients with Type 1 diabetes in this age group. Patients were identified through the local diabetic out-patient registry and asked to complete a questionnaire regarding data on diabetes onset and family history. Of 1574 probands 1419 agreed to participate (90.2%). Additional cases of Type 1 diabetes were found in 171 families (12.8%). Of these 115 were parent-offspring affected families, and in 56 families at least two siblings had Type 1 diabetes and healthy parents. Significant correlation in age at onset of Type 1 diabetes in concordant siblings was observed (r=0.5, p=0.0004). Significantly more probands had an affected father with Type 1 diabetes than a mother affected (p〈0.0001). Heterogeneity in epidemiological characteristics was observed between familial and sporadic cases, i.e. familial index cases were younger at onset of the disease, their parents were younger at birth of the index case, and there was no difference in gender of familial cases in contrast to sporadic cases where significantly more males were found. Over a 4-year period (1986–1989) an increasing trend in incidence was observed. However, an increase in incidence compared to previous Danish data from the 1970s and 1980 s could not be demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400364
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  • 4
    Electronic Resource
    Electronic Resource
    Surface Charges and ION Channel Function (1991)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 53 (1991), S. 341-359 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ph.53.030191.002013
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  • 5
    Electronic Resource
    Electronic Resource
    Conglutinin Binds The HIV-1 Envelope Glycoprotein gpl60 and Inhibits its Interaction with Cell Membrane CD4 (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 33 (1991), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The highly glycosylated envelope glycoprotein (gpl60) of human immunodeficiency virus (HIV) interacts with the CD4 molecule present on the membrane of CD4+ cells and is involved in the pathobiology of HIV infection. Lectins bind glycoproteins through non-covalent interactions with specific hexose residues. The mammalian C-type lectin bovine conglutinin was examined for its ability to interact with recombinant gpl60 (rgpl60) produced in vaccinia virus-infected BHK21 cells. Specific binding of conglutinin to rgp160 was demonstrated by ELISA. The interaction of bovine conglutinin with rgp160 was calcium-dependent, which is characteristic of the binding of a C-type lectin to its ligand, and the binding was inhibited in a dose-dependent manner with A-acetyl-D-glucosamine. Deglycosylation of rgpl60 abrogated the conglutinin binding. In addition, conglutinin exerted a dose-dependent inhibition of the binding of rgp160 to the CD4 receptor on CEM 13 cells, as demonstrated by FACS analyses. These results indicate that conglutinin may inhibit the infection with HIV-1 through its interaction with the viral envelope glycoprotein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1991.tb02494.x
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  • 6
    Electronic Resource
    Electronic Resource
    In Vivo and In Vitro Antibacterial Activity of Conglutinin, a Mammalian Plasma Lectin (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 31 (1990), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Conglutinin is a mammalian C-lype lectin which agglutinates iC3b-coated erylhrocytes, Ingram [13] found that euglobulin from bovine serum may confer partial protection against experimental infections in mice. We now present evidence that the protective activity in euglobulin against infections of BALB/c mice with Salmonella typhimurium is mediated by conglutinin. Conglutinin also demonstrated antibacterial activity against E. coli and S. typhimurium in vitro. The expression of this activity required the presence of heat-labile serum factors and peritoneal exudate or spleen cells, but not antibodies to the bacteria. Antibacterial activity was also demonstrated when the bacteria were prelreated with serum at 37°C before incubation with conglutinin and cells. The activity of conglutinin was not observed when factor I-deficient or EDTA-treated serum was used instead of normal serum. The active peritoneal exudate or spleen cells showed adherence to plastic.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1990.tb02792.x
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  • 7
    Electronic Resource
    Electronic Resource
    Purification, Subunit Characterization and Ultrastructure of Three Soluble Bovine Lectins: Conglutinin, Mannose-Binding Protein and the Pentraxin Serum Amyloid P-Component (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 36 (1992), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Conglutinin and mannose-binding protein (MBP) are members of the C-type lectins which are widely present in mammalian plasma. Serum amyloid P-component (SAP) is a member of the pentraxin family with lectin properties. A scheme for the partial purification of all three lectins by carbohydrate affinity chromatography and selective elution was developed. The purification was monitored by SDS-PAGE, Western blotting and electron microscopy. Binding of the lectins to Sephadex-iC3b. their collagenase sensitivity, and the size and antibody reactivity of their subunits was investigated. The demonstration, by SDS-PAGE, of 25-kDa subunits, which were unaffected by collagenase treatment but bound to Sephadex-iC3b and antibodies to human SAP, indicated the existence of bovine SAP. Bovine conglutinin (BK) also showed calcium-dependent binding to Sephadex-iC3b, whereas bovine MBP did not. The binding of BK was inhibitable with GlcNAc. A 3000-fold increase in BK activity (ELISA) was obtained in eluates from Sephadex iC3b. SDS-PAGE analyses of BK and MBP revealed subunits with an Mr of 43 kDa and 30 kDa, respectively. These subunits were sensitive to collagenase treatment which reduced the Mr to 20 kDa. Electron micrographs revealed a prominent flexible tertramer molecule (diameter 96 nm) in the BK preparations, a predominantly hexameric structure (diameter 30 nm) in the MBP preparations, and single annular pentameric disc-like molecules (diameter 11 nm) in the SAP preparations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1992.tb02949.x
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  • 8
    Electronic Resource
    Electronic Resource
    Intestinal malrotation and volvulus in infancy (1990)
    Springer
    Pediatric surgery international 5 (1990), S. 27-29 
    Details
    ISSN: 1437-9813
    Keywords: Children ; Intestinal malrotation ; Surgical treatment ; Volvulus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intestinal malrotation is most commenly complicated by volvulus in the first weeks of life. Early diagnosis and surgical intervention are needed to prevent gangrene of the midgut and peritonitis. When the diagnosis of intestinal malrotation is suspected, a plain X-ray film of the abdomen must be perfomed. In 4 of 21 cases we found a low intestinal obstruction, which was complicated by a high risk of intestinal gangrene and high mortality. These X-ray findings should lead to emergency surgery. If the plain X-ray film shows the “double bubble sign” (N = 14), then intestinal malrotation and volvulus as well as duodenal atresia are possible diagnosis. As both conditions require surgery, no further examinations are necessary. With a nonspecific pattern (N = 3), a barium meal should be performed in order to classify the disease type. We recommend that operation should be performed in most cases based on the findings on the plain X-ray film and that cases with low intestinal obstruction should be operated upon as emergencies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179634
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  • 9
    Electronic Resource
    Electronic Resource
    Resonant photoemission study ofK-derived valence-band states in K X C60 (1993)
    Springer
    The European physical journal 92 (1993), S. 347-351 
    Details
    ISSN: 1434-6036
    Keywords: 36.40.+d ; 74.75.+t ; 79.60.−i
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The electronic structure of K-doped C60 was investigated by photoemission (PE) and X-ray absorption near-edge structure (XANES) studies at the C-1s and K-2p thresholds. In addition, information on the local K-derived partial density of states in superconducting K3C60 was obtained by resonant PE at the K-2p 1/2 threshold. The experimental observations support a complete charge transfer from K to C60 and we clearly observe a finite density of states atE F . From resonant PE, occupied states with K-p, d character could be identified in the binding-energy region from 1.5 to 8 eV below, but not directly at the Fermi level. This partial-density-of-states structure agrees well with the results of our band-structure calculations based on the local-density approximation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01308753
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  • 10
    Electronic Resource
    Electronic Resource
    An improved HPLC system for the analysis of photosynthetic pigments (1993)
    Springer
    Chromatographia 35 (1993), S. 189-192 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Carotenoid pigments ; Chlorophylls ; Photosynthestic tissue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A high performance liquid chromatography system for the analysis of photosynthetic pigments is presented. The method employs an octadecylsilica stationary phase, a programmed quaternary mobile phase consisting of mixtures of methanol, acetonitrile, water and hexane, and a photodiode array detector. Carotenoids and chlorophylls are rapidly analysed in a single chromatographic separation. Thecis-trans isomers of most carotenoids are separated by this method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02269701
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