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  • 1
    Electronic Resource
    Electronic Resource
    The Pathobiology of Asbestos-Induced Lung Disease: A Proposed Role for Macrophage-Derived Growth Factors (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 643 (1991), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb24468.x
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  • 2
    Electronic Resource
    Electronic Resource
    Control of Lung Fibroblast Proliferation by Macrophage-derived Platelet-derived Growth Factor (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 725 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb39801.x
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  • 3
    Electronic Resource
    Electronic Resource
    Nucleolar organizer regions and glycoprotein-hormone α-chain reaction as markers of malignancy in endocrine tumours of the pancreas (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 22 (1993), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The value of silver staining of nucleolar organizer regions (AgNORs) and human chorionic gonadotropin α-chain reaction (HCG-α) as markers of malignancy was investigated in 60 primary pancreatic endocrine tumours, 37 of which had metastasized at the time of surgery, and in one of which metastases developed 4 years after surgery. Assessment of AgNORs by digital image analysis revealed few but large AgNORs (mean number 2.5 ± 1.1; mean area ± in the 22 benign tumours and many but small AgNORs (mean number 5.1 ± 1.9, P〈0.05; mean ± 9 μm2. P〈0.01) in the malignant tumours. Quantification of the number of AgNORs per tumour cell AgNOR distribution score) showed that 96% (26/27) of tumours exhibiting at least 5% of cells with more six AgNORs per nucleolus showed metastases either at the time of diagnosis or up to 4 years after surgery. HCG-α immunoreactive cells were present in 25/38 (66%) malignant tumours and in 4/22 (18%) benign tumours. Combined evaluation of AgNOR distribution and HCG-α scores showed a high positive predictive value of 96% in cases with a raised AgNOR distribution score irrespective of the HCG-α status. A good negative predictive value (81%) was, however, only obtained if both parameters, AgNOR distribution and HCG-α scores, were negative. Thus, investigation of AgNORs HCG-α is helpful in predicting malignancy in a high percentage of pancreatic endocrine tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1993.tb00069.x
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  • 4
    Electronic Resource
    Electronic Resource
    A mathematical model to predict Sorghum halepense (L.) Pers. seedling emergence in relation to soil temperature (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Weed research 30 (1990), S. 0 
    Details
    ISSN: 1365-3180
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: A mathematical model to predict Sorghum hale-pense seedling recruitment dynamics in relation to soil temperature was derived from the experimen-tal results obtained in a previous investigation. The model is based on the assumption that soil temperature controls seedling recruitment of S. halepense by controlling release from dormancy and germination rate once dormancy breakage has been produced. The previous analysis sup-plied mathematical functions to describe both the release from dormancy as controlled by tempera-ture fluctuations, and the response to ‘thermal time’ after dormancy breakage. These relation-ships were used in the construction of the model. This was tested against experimental field data with two differently aged seedbanks, in two seasons: spring and autumn. In each case in situ germination was monitored in plots with bare soil or soil surface shaded to simulate cover by a canopy. Soil temperature was recorded hourly and was used as an input of the model.A good description of seedling emergence dynamics in the field was obtained with the model, showing that seedling recruitment can be predicted using soil temperature data. The practi-cal value of the developed model is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3180.1990.tb01691.x
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  • 5
    Electronic Resource
    Electronic Resource
    Temperature effects on dormancy release and germination rate in Sorghum halepense (L.) Pers. seeds: a quantitative analysis (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Weed research 30 (1990), S. 0 
    Details
    ISSN: 1365-3180
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Seed dormancy in Sorghum halepense is overcome by exposure to fluctuating temperatures and the effect is determined both by the diurnal amplitude and the maximum temperature. It was found that repeated cycles of particular regimes were additive, each cycle resulting in release from dormancy of a further proportion of the population. The range of regimes having this additive effect was wider in seeds which had after-ripened in the soil during winter than in those which were freshly dispersed. The temperature-dependent germination rate of seeds whose dormancy had been removed by the effect of fluctuating temperatures was analysed using a ‘thermal time’ approach, and estimates obtained of base and optimum temperatures and the required ‘thermal time’ for the germination of different fractions of the population. The results provide a basis for developing a model to predict seedling recruitment in the field using soil temperature data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3180.1990.tb01690.x
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  • 6
    Electronic Resource
    Electronic Resource
    Radiation-driven inertial fusion targets for implosion experiments: Theoretical analysis and numerical simulations (1991)
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 3 (1991), S. 1717-1727 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: This paper presents numerical simulations of compression, ignition, and burn of a radiation-driven inertial fusion capsule suitable for use in a heavy-ion-beam-driven laboratory microfusion facility to achieve breakeven (thermonuclear energy output=input radiation energy). These simulations have been carried out using a one-dimensional, three-temperature, Lagrangian computer code medusa-kat [J. Appl. Phys. 60, 898 (1986)]. The basic capsule design is simple and consists of a thin gold microballoon coated with a beryllium ablator. A high-pressure gaseous deuterium–tritium (DT) fuel is filled in the capsule. The capsule is driven by a shaped radiation pulse having a prepulse corresponding to a radiation temperature of 100 eV and a main pulse with a temperature of 300 eV. A parameter study of the capsule gain, G versus input radiation energy over a range 52–76 kJ, has been carried out. The fuel mass has also been varied over a range 0.3–0.8 μg. It has been found that G∼1 can be achieved with an absorbed radiation energy of 70 kJ provided that the fuel mass lies between 0.5 and 0.7 μg. These simulations have also been repeated over the same parameter range but using an unshaped pulse with a constant radiation temperature of 300 eV. An overall reduction of 10%–30% has been observed in the gain curves in this case.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.859691
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  • 7
    Electronic Resource
    Electronic Resource
    Accelerator and target studies for heavy ion fusion at the Gesellschaft für Schwerionenforschung (1990)
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 2 (1990), S. 1313-1317 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The new Schwerionen-Synchrotron (SIS)/Experimenteller Speicher-Ring (ESR) heavy ion accelerator facility [Nucl. Instrum. Methods A 278, 7, 19 (1989)], built for basic atomic and nuclear physics at Darmstadt (Federal Republic of Germany), also provides unique possibilities to study rf accelerator and beam/target interaction physics for inertial confinement fusion driven with heavy ion beams. It is the first machine that offers this opportunity. Beam parameters and experiments planned over the next five years are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.859548
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  • 8
    Electronic Resource
    Electronic Resource
    Serum gastrin levels during long-term omeprazole treatment (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 4 (1990), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Serum gastrin was determined in 33 patients during treatment with the proton pump inhibitor omeprazole. After 4 weeks of therapy, gastrin levels increased to a median of 55 pg/ml compared to 15 pg/ml prior to omeprazole (P 〈 0.001). There was a close correlation (r= 0.939; P 〈 0.001) between pre-treatment gastrin and levels at 4 weeks. Comparison of serum gastrin concentrations at I month of omeprazole with levels at 6 (n= 21) and 12 months (n= 12) continuous therapy revealed a close correlation (r= 0.961 and r= 0.882, respectively; P 〈 0.001) despite dose adjustment. In marked hypochlorhydria documented by continuous pH monitoring, serum gastrin varied from normal up to profound hypergastrinaemia. These results demonstrate that the serum gastrin increase under powerful acid-inhibitory drug therapy depends upon a number of variables. (a) Only in patients with elevated gastrin levels, prior to omeprazole treatment, can moderate to marked hypergastrinaemia during omperazole be expected. (b) Gastrin increases reached during the initial period of omeprazole treatment remain constant during long-term therapy. (c) Acid inhibition itself is not necessarily associated with an increase in serum gastrin in every patient, which suggests that the individual sensitivity of the gastrin cell to acid inhibition is more important for serum gastrin changes than the degree of acid inhibition itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1990.tb00457.x
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  • 9
    Electronic Resource
    Electronic Resource
    Prospective evaluation of omeprazole treatment in reflux oesophagitis refractory to H2-receptor antagonists (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 4 (1990), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The efficacy of omeprazole therapy (40 mg daily) in H2-blocker refractory severe reflux oesophagitis (Grade II-IV; Savary and Miller classification) was investigated in 61 patients. Mean duration of reflux disease and preceding H2-antagonist treatment were 4.3 years and 15 months, respectively. Healing rates at 4, 8 and 12 weeks were 48%, 80% and 92%, respectively. There was a correlation between severity of oesophagitis and duration of omeprazole therapy necessary for healing. Three patients (5%) required higher dosages than 40 mg for healing. Symptomatic responses paralleled healing. It is concluded that omeprazole is a highly effective drug for severe reflux oesophagitis not responding to H2-blocker treatment and that 40 mg daily is the optimal dose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1990.tb00507.x
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  • 10
    Electronic Resource
    Electronic Resource
    An open trial of long-term therapy with lansoprazole in patients with peptic ulceration resistant to extended high-dose ranitidine treatment (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 7 (1993), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Forty-two patients with peptic ulceration of the duodenum, stomach or oesophagus, who had not responded to 3 or more months of high-dose treatment with ranitidine (450 or 600 mg/day), were treated with oral lansoprazole at 30–60 mg daily. In 40 patients (95.2%) the ulcers healed within 2–12 weeks. In the remaining 2 patients healing took several months but eventually all ulcers healed. After healing, 40 patients underwent long-term maintenance treatment with 30–60 mg lansoprazole daily for 1–3 years (continuing). During maintenance therapy with lansoprazole, no endoscopically verified relapses occurred when the drug was taken regularly. In 1 patient treatment had to be discontinued because of a drug-related colitis that disappeared soon after treatment had been stopped. There were no significant changes in routine laboratory tests in any patient. Basal serum gastrin concentrations, which were already elevated by the previous high-dose ranitidine treatment (125 ± 25 pg/ml), rose to four times the normal values after 4 weeks of treatment with lansoprazole (255 ± 65 pg/ml). Thereafter no further increases in basal serum gastrin concentrations were observed, even after 3 years of administration. The volume density of argyrophilic cells in the oxyntic mucosa increased slightly during lansoprazole treatment; until now no dysplasia of the enterochromaffin-like cells has been observed. In conclusion, 30–60 mg lansoprazole daily healed ranitidine-resistant peptic ulcers, and subsequent maintenance therapy with 30–60 mg lansoprazole daily was found to be highly effective and safe over the time observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1993.tb00589.x
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