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  • 1990-1994  (8)
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  • 1
    Digitale Medien
    Digitale Medien
    One-year follow up of children treated with Chinese medicinal herbs for atopic eczema (1994)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 130 (1994), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The opportunity to continue treatment was offered to the parents of 37 children who had completed a double-blind placebo-controlled trial of a specific formulation of Chinese medicinal herbs for atopic eczema. The parents elected for continued treatment in every case, and the progress of the children was monitored over the following 12 months. The aim was to achieve a substantial clinical improvement, and thereafter to reduce treatment frequency progressively while maintaining this benefit.At the end of the year, 18 enjoyed at least 90% reductions in eczema activity scores, and five showed lesser degrees of improvement. Fourteen children withdrew from the study, 10 due to lack of response, and four because of unpalatability of treatment or difficulty in the preparation of treatment. By the end of the year, seven of the children were able to discontinue treatment without relapse. The other 16 required treatment to maintain control of their eczema, but only four of these still required daily treatment.Asymptomatic elevation of serum aspartate aminotransferase to 7–14 times normal values was noted on one occasion in two children whose eczema was so well controlled that the therapy was stopped. Liver function tests were normal 8 weeks later.We conclude that Chinese medicinal herbs provide a therapeutic option for children with extensive atopic eczema which has failed to respond to other treatments. In the medium term, it proved helpful for approximately half the children who originally took part in our placebo-controlled trial. The possibility that it may provoke hepatic abnormalities requires further study. In the meantime, it seems prudent to monitor liver function tests regularly, and to minimize the duration of treatment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.1994.tb03383.x
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  • 2
    Digitale Medien
    Digitale Medien
    Waxy keratoses of childhood (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 19 (1994), S. 0 
    Details
    ISSN: 1365-2230
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Three cases of waxy keratoses of childhood occurring in two families are described. The disorder seen in these three cases appears to be clinically and histopathologicaly distinct from previously distinct from previously described familial disorders of keratinization, which also feature multiple discrete papules.1–7
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2230.1994.tb01153.x
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  • 3
    Digitale Medien
    Digitale Medien
    A double-blind controlled trial of hyposensitization to Dermatophagoides pteronyssinus in children with atopic eczema (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 22 (1992), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: A double-blind controlled trial of hyposensitization with tyrosine-adsorbed Dermatophagoides pteronyssinus vaccine in 24 children with atopic eczema and immediate hypersensitivity to D. pteronyssinus failed to demonstrate superiority over placebo after a standard 8 month course of treatment.In a second phase, children initially administered active treatment were randomly allocated to continue with active treatment or switched to placebo for a further 6 months. The clinical scores suggest that prolonged hyposensitization may be more effective than placebo but the numbers were too small to permit confident conclusions. A dramatic placebo effect may have served to conceal any additional therapeutic effect from active treatment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2222.1992.tb00145.x
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  • 4
    Digitale Medien
    Digitale Medien
    Elimination diet and intestinal permeability in atopic eczema: a preliminary study (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 23 (1993), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: We measured small intestinal permeability to lactutose and rhamnose in 18 healthy children and in 15 children with atopic eczema, before and after a 14-day elimination diet. The children with atopic eczema had higher initial urinary lactulose/rhamnose ratios than the controls. After dietary restriction, there was no overall change in permeability. Dietary therapy did however result in a large reduction in permeability in three of the nine children whose skin disease was improved, but a statistically significant decrease in permeability was not observed in the diet-responsive group as a whole. Larger studies would be required to confirm that dietary restrictions can reduce intestinal permeability in some children with atopic eczema.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2222.1993.tb02480.x
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  • 5
    Digitale Medien
    Digitale Medien
    Atopic disease and food allergy (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 21 (1991), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2222.1991.tb03190.x
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  • 6
    Digitale Medien
    Digitale Medien
    Juvenile colloid milium: clinical, histological and ultrastructural features (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 19 (1992), S. 0 
    Details
    ISSN: 1600-0560
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: We report the clinical, histological and ultrastructural features of juvenile colloid milium affecting a brother and sister. In this rare condition, translucent papules develop on sun-exposed areas of skin, with onset in childhood. Histologically and ultrastructurally, the papules consist of amyloid-like material derived from epidermal keratonocytes. A review of the literature suggests a possible genetic abnormality that leads to sun-induced degeneration of keratinocytes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0560.1992.tb00617.x
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  • 7
    Digitale Medien
    Digitale Medien
    Pellagra with colitis due to a defect in tryptophan metabolism (1991)
    Springer
    European journal of pediatrics 150 (1991), S. 498-502 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Kynurenine hydroxylase ; Tryptophan metabolism ; Nicotinamide deficiency ; Pellagra ; Colitis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A 9-year-old girl presented with a red scaly rash confined to sun-exposed areas which started at 2 years of age and had the appearance of pellagra. Investigation of urinary tryptophan metabolites following an oral tryptophan load, showed increased excretion of kynurenine and kynurenic acid but reduced excretion of 3-hydroxy-kynurenine, xanthurenic acid and N1-methyl nicotinamide. These results indicated a defect in the hydroxylation of kynurenine, an important reaction in the synthesis of the nicotinamide nucleotide coenzymes, NAD and NADP, from tryptophan. The patient went on to develop severe colitis and psychological changes. All her symptoms responded to treatment with nicotinamide.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01958432
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  • 8
    Digitale Medien
    Digitale Medien
    Sclerema neonatorum and subcutaneous fat necrosis of the newborn in the same infant (1990)
    Springer
    European journal of pediatrics 150 (1990), S. 125-126 
    Details
    ISSN: 1432-1076
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Sclerema neonatorum (SN) is a rare disease of the newborn characterised by diffuse hardening of the subcutaneous adipose tissue. The condition is distinct from the localised violacious nodules observed in subcutaneous fat necrosis of the newborn (SCFN). Both conditions were diagnosed within the first 2 weeks of life in the same infant. SN and SCFN are unusual conditions in the newborn, the former usually associated with a severe clinical illness, following delivery or major surgery. The skin lesions of these two conditions are distinct and do not usually occur simultaneously. SN is associated with a poor prognosis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02072054
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