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  • 1
    Electronic Resource
    Electronic Resource
    Hypomagnesaemia in Type 2 (non-insulin-dependent) diabetes mellitus is not corrected by improvement of long-term metabolic control (1992)
    Springer
    Diabetologia 35 (1992), S. 77-79 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; Type 2 (non-insulin-dependent) diabetes ; insulin resistance ; magnesium ; electrolytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Low levels of magnesium have frequently been reported in diabetes mellitus especially in poorly controlled Type 1 (insulin-dependent) diabetic patients. Furthermore hypomagnesaemia might contribute to insulin resistance in Type 2 (non-insulin-dependent) diabetes. As the influence of improved metabolic control on plasma magnesium levels is unknown in Type 2 diabetic patients we studied magnesium plasma levels in 50 patients 1) before, 2) one and 3) three months after the initiation of insulin therapy or intensified treatment with oral hypoglycaemic agents. Magnesium plasma levels were measured by a colorimetric method and were significantly reduced in diabetic patients compared to healthy control subjects (0.79±0.01 mmol/l vs 0.88±0.01 mmol/l; p〈0.0001). Metabolic control was significantly improved as documented by reduced HbA1C levels in both insulin-treated patients or the patients on oral hypoglycaemic agents (p〈0.003). However, plasma magnesium levels remained unchanged during the follow-up in the insulin-treated group (1∶0.79±0.02 mmol/l; 2∶0.81±0.02 mmol/l; 3∶0.79±0.01 mmol/l) as well as in the patients on oral hypoglycaemic agents (1∶0.79±0.03 mmol/l; 2∶0.78±0.02 mmol/ l; 3∶0.84±0.04 mmol/l). This study shows that even marked improvement of glycaemic control does not correct hypomagnesaemia in Type 2 diabetes. We conclude that hypomagnesaemia might be related to the insulin-resistant state and that possible beneficial effect of chronic magnesium administration should be evaluated in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400855
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    First analysis of the F508 deletion in cystic fibrosis patients from the GDR (1990)
    Springer
    Human genetics 〈Berlin〉 85 (1990), S. 406-407 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cystic fibrosis (CF) patients (n = 157) from the GDR were analysed for the occurrence of the recently discovered 3bp deletion causing CF. About 50% of all investigated patients were homozygotes and about 30% heterozygotes for this deletion. Of the analysed CF chromosomes from these patients, 62% carry the deletion, which is in strong linkage disequilibrium with the KM19 restriction fragment length polymorphism allele 2 and the 1/2 XV2c/KM19 haplotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02428280
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Synthesen in der Isocamphanreihe, 39. Mitt.: Verbesserung derDiels-Alder-Reaktion von Cyclopentadien mit Mesityloxid durch Ultraschall und eine neue Synthese von Dehydrocamphen (1994)
    Springer
    Monatshefte für Chemie 125 (1994), S. 921-925 
    Details
    ISSN: 1434-4475
    Keywords: 2-Acetyl-3,3-dimethylbicyclo[2.2.1]hept-5-ene ; Camphene ; 5,5-Dimethyl-6-methylenebicyclo[2.2.1]hept-2-ene ; Isocamphane derivatives ; Isocamphodiene ; Norborn-5-ene derivatives ; Odour ; Sonification ; Ultrasound chemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The synthesis of the valuable terpenic synthon 2-acetyl-3,3-dimethylbicyclo[2.2.1]hept-5-ene is clearly improved concerning the yield and especially the reaction time by applying ultrasound on theDiels-Alder reaction of cyclopentadiene with mesityl oxide. A new synthesis of dehydrocamphene and its odour impression is described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00812706
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    Paper (German National Licenses)
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