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  • 1
    Electronic Resource
    Electronic Resource
    Responses to eccentric rotation in two space-bound subjects (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 757-760 
    Details
    ISSN: 1432-1440
    Keywords: Rotating chair ; Otolith ; Vestibular system ; Asymmetry ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two subjects were rotated eccentrically in the manner described previously. In contrast to a normal control group, settings of a luminous line to the subjective vertical were almost unrelated to the gravitoinertial vector before, and totally so shortly after, space flight. Only 3 days postflight did a clear relation to the gravitoinertial vector re-establish itself in the one subject who actually flew. The correspondence became normal 5 days after the flight. Since there were no clinical abnormalities evident in the subjects, it is suggested that both subjects suppressed their vestibular information, presumably as an effect of vestibular deconditioning training before the flight. In addition, as a consequence of the flight experience one subject continued to ignore it several days after the flight.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00209731
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Oculovestibular interactions under microgravity (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 749-756 
    Details
    ISSN: 1432-1440
    Keywords: Visual vestibular interaction ; Ocular counterrotation ; Afterimage method ; Luminous line ; Neck position receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary On a space mission in March 1992 a set of experiments were performed aimed at clarifying the interaction between visual, proprioceptive and vestibular inputs to the equilibrium system. Using the VESTA goggle facility from the European Space Agency we investigated the effect of pure neck receptor stimulation on eye position as measured by the flash afterimage method and on perception of a head-fixed luminous line in space. Space vestibular adaptation processes were measured by rotating pattern perception during prescribed head movements. It was found that static ocular counterrotation does not occur under micro gravity conditions. This result suggests that the neck receptors apparently do not contribute to a measurable extent. The subjective orientation of a vertical line was perceived correctly inflight. Obviously neck receptors on the perception level can fully substitute for the ineffective equilibrium organs of the inner ear within less than 4 days. The rotating pattern perception during different head motion patterns is not influenced by the absence of a gravity reference.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00209730
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Hepatitis C virus (HCV) genotype distribution in German isolates: studies on the sequence variability in the E2 and NS5 region (1994)
    Springer
    Archives of virology 139 (1994), S. 379-388 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report on molecular characterization of hepatitis C virus (HCV) isolates in intravenous drug abusers, as compared to non-drug using patients with posttransfusion hepatitis or sporadic hepatitis of unknown origin. Virus typing was performed by RFLP analysis of PCR products in the 5′ NCR. Subtyping was done by hybridization with subtype specific probes or by sequencing in the NS4 and NS5 region, respectively. HCV subtype 1b was found most commonly among all the isolates. However, the subtype 3a had a high prevalence (about 46%) in the group of drug addicts. In these subtype 3a isolates the N-terminal part of the E2 protein was highly variable. This confirms the presence of a hypervariable region (HVR1) in this envelope protein found in all hepatitis C viruses. Each subtype 3a isolate examined had a characteristic unique hypervariable region in the E2 protein. It is noteworthy that there are four amino acids in this region which were highly conserved between all HCV sequences published. It can be assumed that such conserved amino acids are significant for structure and function of this viral protein. In our HCV subtype 3a isolates the NS5 sequences were highly conserved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01310799
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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