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Caudate nucleus pathology in Parkinson's disease: ultrastructural and biochemical findings in biopsy material (1992)

Lach, B. ; Grimes, D. ; Benoit, B. ; [et al.]

Springer

Acta neuropathologica 83 (1992), S. 352-360

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ISSN: 1432-0533

Keywords: Parkinson's disease ; Ultrastructure ; Catecholomines ; Trans-synaptic degeneration ; Axonal dystrophy

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Ultrastructural and biochemical properties of caudate nucleus (CN) biopsies in two patients with advanced Parkinson's disease (PD) were compared with three CN specimens removed during surgery for intracranial tumors. An additional two specimens from neurologically intact patients (59 and 86 years old) were removed during autopsy (performed 3 and 4 h post mortem, respectively) for electron microscopic studies. Dopamine levels in PD were reduced to less than 15% of control values. Both PD patients showed frequent dystrophic neurites and transsynaptic degeneration of neurons and neuritic processes. These changes were not found in CN from the four control individuals. Only a few dystrophic neurites were noticed in one 67-year-old control patient. The development of neuroaxonal dystrophy in CN is consistent with a dying-back process, probably accompanying abnormalities of axonal transport in PD. Transsynaptic degeneration of neurons in CN very likely represents a morphological marker of disease severity. The occurrence of this change may account for the poor clinical response of patients with advanced PD to intracerebral implantation of dopaminergic tissues.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00713525

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The potential distribution around growing fractal clusters (1990)

Mandelbrot, Benoit B. ; Evertsz, Carl J. G.

[s.l.] : Nature Publishing Group

Nature 348 (1990), S. 143-145

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] The DLA model of Witten and Sander1 captures the essential fractal aspects of a wide range of physical phenomena2-7, such as particle aggregation, dielectric breakdown, viscous fingering and electrochemical deposition. In DLA growth, an 'atom' executes Brownian motion until it hits, and becomes ...