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  • 1
    Electronic Resource
    Electronic Resource
    Mapping the gene encoding the human erythroid transcriptional factor NFE1-GF1 to Xp11.23 (1991)
    Springer
    Human genetics 〈Berlin〉 86 (1991), S. 388-390 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The X-linked NFE1 gene encodes an erythroid factor involved in globin gene transcription. Using a human cDNA clone encoding this factor, we show, by in situ hybridization and by analysis of human-rodent hybrid cell lines, that this gene is located in Xp11.23. In the absence of polymorphisms in the NFE1 gene, these results allow the study of the possible relationships between NFE1 mutations and X-linked hereditary persistence of fetal hemoglobin by linkage analysis with RFLP markers of the region. A female patient, hemizygous for the NFE1 locus, shows essentially normal hematological parameters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00201840
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of cold stress on postprandial lower esophageal sphincter competence and gastroesophageal reflux in healthy subjects (1992)
    Springer
    Digestive diseases and sciences 37 (1992), S. 1200-1205 
    Details
    ISSN: 1573-2568
    Keywords: esophageal function ; esophagus ; gastroesophageal reflux ; stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of cold stress on postprandial lower esophageal sphincter competence and gastroesophageal reflux was investigated in nine healthy subjects. All subjects were studied twice in a randomized order according to a common protocol: 30 min after completion of a 700-kcal meal they put their nondominant hand in water either at 37°C (control stimulus) or at 4°C (stressful stimulus) cyclically for 20 min. Pulse rate and blood pressure rose significantly (P〈0.01) during the stressful stimulus, but remained unaffected by the control stimulus. Rate of transient lower esophageal sphincter relaxations/30 min [median (interquartile range)] was similar before and during control stimulus, 4 (2.7–5.0) and 3 (2.0–4.5), respectively, whereas it was markedly inhibited during the stressful stimulus [from 5 (3.7–6.0) to 2 (1.0–2.0);P〈0.05 vs control stimulus]. Rate of reflux episodes/30 min was also similar before and during control stimulus, 1 (0–1.2) and 1 (1.0–2.2), but fell consistently during the stressful stimulus [from 2 (0–3.2) to 1 (0–2.0);P〈0.05 vs control stimulus]. Percentage of transient lower esophageal sphincter relaxations accompanied by a reflux episode was unaffected by stress as was basal lower esophageal sphincter pressure. It is concluded that cold stress decreases the postprandial rate of transient lower esophageal sphincter relaxations and reflux episodes in healthy humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296560
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Prevalence of HIV infection in 646 heroin addicts and outcome of HIV-related conditions in the 266 followed up (1991)
    Springer
    European journal of epidemiology 7 (1991), S. 83-87 
    Details
    ISSN: 1573-7284
    Keywords: HIV ; Hepatitis B ; Hepatitis delta ; Heroin users ; AIDS-related complex (ARC) ; AIDS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a series of 646 heroin addicts anti-HIV was detected in 428 (66.2%) and HBsAg in 53 (8.2%). Forty-eight (90.5%) of the latter had concomitant chronic HDV infection. Markers of past HBV infection were found in 481 (74.4%). The prevalence of anti-HIV was significantly higher in the 534 subjects with HBV markers than in the other 112 without markers (69.8% versus 49.1%, p 〈 0.001). Of the 266 anti-HIV positive subjects followed for 3–48 months (median 12), nine progressed from no disease to persistent generalized lymphadenopathy (PGL), 52 from PGL to AIDS-related complex (ARC) or AIDS (30 and 22 cases respectively), and six from ARC to AIDS. Baseline T4 + cell count was significantly lower and reduction during follow-up significantly greater in heroin addicts with disease progression than in those without.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221346
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    Paper (German National Licenses)
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