Electronic Resource
Springer
Springer seminars in immunopathology
12 (1990), S. 121-128
ISSN:
1432-2196
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Conclusion A number of recent studies have been discussed which provide strong evidence that genetic and immunological factors are important in the pathogenesis of PSC. Current evidence suggests that PSC is, like primary biliary cirrhosis, an immunologically mediated disease [8]. It seems likely that the immunological destruction of the biliary system is triggered in genetically predisposed individuals by viruses or bacteria [8]. The association with ulcerative colitis may be explained by the passage of viral or bacterial organisms across the damaged colonic epithelial barrier into the systemic circulation. Further studies are needed to confirm this attractive hypothesis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00192687
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