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  • 1
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 119-121 (Jan. 1993), p. 365-370 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 119-121 (Jan. 1993), p. 101-108 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nutrition 32 (1993), S. 131-138 
    ISSN: 1436-6215
    Keywords: Pestizide ; Kombinationswirkungen ; Mutagenität ; Genotoxicity ; quercetin ; herbicides ; atrazine ; cyanazine ; combination effects ; SCE test ; HPRT test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary The plant flavonol quercetin and the triazine herbicides atrazine, cyanazine, and gesamprim were examined individually and in combination for the induction of genotoxic effects. The sister chromatid exchange (SCE) assay and the gene mutation assay for 6-thioguanine resistance (HPRT) were carried out with Chinese hamster ovary (CHO) cells. Whereas no evidence of an increased SCE rate was found, the test substances caused a slightly increased mutation rate in the HPRT assay after metabolic activation with a subcellular liver enzyme preparation. Combination studies with two or three of the test substances did not result in higher mutation rates than those observed for the individual compounds tested singly.
    Notes: Zusammenfassung Das in Plfanzen vorkommende Flavonol Quercetin und die zu den Triazinen gehörenden Herbizide Atrazin, Cyanazin und Gesamprim® wurden einzeln und in Kombination miteinander auf genotoxische Wirkungen untersucht. Es wurden die Induktion von Schwesterchromatidaustauschen (SCE-Test) und von Mutationen zur 6-Thioguaninresistenz (HPRT-Test) an Ovarzellen des Chinesischen Hamsters (CHO-Zellen) bestimmt. Während sich in SCE-Test keine Hinweise auf genotoxische Wirkungen ergaben, verursachten die Prüfsubstanzen im HPRT-Test nach metabolischer Aktivierung durch zugesetzte subzelluläre Enzympräparate der Rattenleber (S9-Mix) leicht erhöhte Mutationsraten. Die Kombinationen von zwei oder drei Prüfsubstanzen verursachten keine deutliche Zunahme der genotoxischen Wirkung.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1436-6215
    Keywords: Nahrungsfolate ; Folatanalytik ; Folatverfügbarkeit ; Folatmetabolismus ; Food folates ; analysis of folates ; folate bioavailability ; folate metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary Because of the unequal and, in some instances, low stability of different folate vitamers against extreme conditions the analytical determination of folate and the estimation of folate losses in food processing and preparation cause considerable difficulties. HPLC allows determination of the native folate derivative patterns. As the bioavailability of folates is influenced by a variety of factors and different methods were employed for assessing bioavailability there is a considerable inconsistency in the results of these studies. Folates labeled with radioactive or stable isotopes provide new approaches to metabolic and bioavailability studies.
    Notes: Zusammenfassung Wegen der unterschiedlichen, zum Teil geringen Stabilität der einzelnen Folatvitamere gegenüber extremen Bedingungen bereitet sowohl die analytische Folatbestimmung als auch die Abschätzung der Folatverluste bei der Lebensmittelverarbeitung und-zubereitung erhebliche Schwierigkeiten. Mit Hilfe der HPLC ist es möglich, Aussagen über das native Folatderivatmuster zu treffen. Da die Bioverfügbarkeit der Folate von vielen Faktoren beeinflußt wird und zur Bioverfügbarkeitsbestimmung unterschiedliche Methoden eingesetzt wurden, ist die Inkonsistenz der Ergebnisse erheblich. Mit radioaktiven oder stabilen Isotopen markierte Folate haben neue Wege in Bioverfügbarkeits- und Metabolismusuntersuchungen eröffnet.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nutrition 29 (1990), S. 74-75 
    ISSN: 1436-6215
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nutrition 30 (1991), S. 319-324 
    ISSN: 1436-6215
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nutrition 33 (1994), S. 164-166 
    ISSN: 1436-6215
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nutrition 31 (1992), S. 225-245 
    ISSN: 1436-6215
    Keywords: Ernährungsempfehlungen ; Ernährung und Krebs ; Ernährung und HerzKreislauf-Erkrankungen ; Lebensmittelzusatzstoffe ; Lebensmittelkontaminanten, Ernährungsberatung ; Dietary guidelines ; nutrition and cancer ; nutrition and cardiovascular disease ; food additives ; food contaminants ; nutrition counseling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary In the 1950s to '70s, food additives and contaminants were considered important risk factors for cancer and other chronic diseases. Opinion leaders like F. Eichholtz and W. Kollath in Germany and R. Carson and J.J. Delaney in the United States maintained that the exclusion of man-made chemicals from the food supply would decisively contribute to better health. In contrast to these views, world-wide scientific opinion now emphasizes the role of personal lifestyle, e.g., over-nutrition, unbalanced diets, smoking, and excessive alcohol consumption in the causation of chronic diseases. Dietary guidelines now recommended for the prevention of cancer are largely identical with those recommended for the prevention of cardiovascular disease. Indications are that oxidative damage to DNA contributes importantly to both these diseases. In research the role of antioxidants and other protective substances in foods receives as much attention today as man-made carcinogens received in the past. Media reporting and nutrition counseling have taken very little notice of these fundamental changes in scientific opinion.
    Notes: Zusammenfassung In den 1950er bis '70er Jahren wurden Lebensmittelzusatzstoffe und Kontaminanten als wichtige Risikofaktoren für Krebs und andere chronische Krankheiten betrachtet. Einflußreiche Persönlichkeiten wie F. Eichholtz und W. Kollath in Deutschland und R. Carson und J.J. Delaney in den Vereinigten Staaten vertraten die Ansicht, daß die Verbannung synthetischer Stoffe aus der Nahrung entscheidend zur Verbesserung der Volksgesundheit beitragen würde. Im Gegensatz zu dieser Auffassung wird aus wissenschaftlicher Sicht heute weltweit vor allem der Rolle des persönlichen Lebensstils, z.B. der überernährung, der Fehlernährung, dem Rauchen und dem Alkoholabusus, Bedeutung als Ursache chronischer Krankheiten zugemessen. Ernährungsempfehlungen für die Vermeidung von Krebs und von kardiovaskulären Krankheiten sind weitgehend identisch. In beiden Fällen scheint die oxidative Schädigung der DNA eine wichtige kausale Rolle zu spielen. In der Forschung finden heute Antioxidantien und andere protektive Substanzen in der Nahrung ebensoviel Beachtung wie früher die synthetischen Karzinogene. Die Berichterstattung in den Medien und die Ernährungsberatung haben von diesem grundlegenden Wandel in den wissenschaftlichen Ansichten bisher sehr wenig Notiz genommen.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 348 (1994), S. 842-842 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A method is presented for the determination of urine folates by a commercial radio-proteinbinding assay widely used in clinical diagnostics for assessing plasma folate levels. Good recovery of urine folates over the range of the calibration curve was observed. Because of the speed, sensitivity and precision of this test, urine folate levels can be measured in bioavailability studies or for the assessment of folate status.
    Type of Medium: Electronic Resource
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