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  • 1990-1994  (4)
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  • 1
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ninety-eight patients (26 females), who presented with erosive and/or ulcerative oesophagitis, despite at least a 3-month period of treatment with standard doses of cimetidine (≥ 1200 mg daily) or ranitidine (≥ 300 mg daily), were included in a double-blind, randomized trial to compare omeprazole (40 mg o.m.) with a high dose of ranitidine (300 mg b.d.). The treatment was given for 4–12 weeks; endoscopy assessment and laboratory screening were performed on entry to the trial and thereafter every fourth week. Endoscopic healing was defined as complete epithelialization of all macroscopic erosions or ulcers in the squamous epithelium. An ‘intention-to-treat’analysis of the clinical datarevealed omeprazole to be superior to ranitidine : 63 % of those patients who were given omeprazole were heaIed endoscopically after a 4-week period of treatment, compared with only 17 % of those given ranitidine. This difference in healing rate persisted during the 12-week study period (90% DS 47% after 12 weeks; P 〈 0.0001). Reflux symptoms were more rapidly and completely relieved with omeprazole : heartburn resolved completely in 86% of patients treated with omeprazole for 4 weeks compared with 32% in the ranitidine group (P 〈 0.0001). The mean basal gastrin concentrations increased only in those given omeprazole from 18.9 pmol/L at pre-entry to a mean value of 31.7 pmol/L on the last day of omeprazole administration. In ranitidine-treated patients no significant increase in basal gastrin concentration was observed. Both drugs were well tolerated with few adverse events, which were mainly mild and transient. These results demonstrate the superiority of omeprazole over a high dose of ranitidine in the treatment of resistant reflux oesophagitis.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 5 (1991), S. 0 
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect of cisapride on duration of post-operative ileus after surgery was investigated in a randomized, double-blind, placebo-controlled study. Patients undergoing elective upper gastrointestinal (n= 47) or colonic (n= 22) surgery were pre-operatively randomly allocated to treatment with either cisapride 30 mg t.d.s., by rectal administration, or placebo. Treatment started exactly 48 h after surgery if the patient at this time had not passed stool. Time to passage of first stool after surgery was estimated.Mean time to passage of stool was 85 (32) h (s.d.) for cisapridetreated and 91 (43) h for placebo-treated patients. No difference between the treatment groups was noted.Treatment with cisapride did not shorten the duration of postoperative ileus after either upper gastrointestinal or colonic surgery.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 692 (1993), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1434-601X
    Keywords: 21.10.−K ; 21.60.−n ; 25.70.−z ; 27.70.+q
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The strongly shape driving πh9/2[541]l/2− configuration with α=+1/2 exhibits some anomalous, and so far unexplained, features concerning the crossing frequency, ħωc, the aligned angular momentum, ix, and interaction strength, at the alignment of the first pair of i13/2 quasineutrons in several odd-Z rare earth-nuclei. The h9/2[541]1/2− and h11/2[523]7/2− bands have been studied in the stably deformed rare-earth nucleus163Tm to investigate these features. A difference in band crossing frequency of ∼ 80 keV between the two bands is found. Rotational bands built on these two configurations have been found to cross in the spin range I=25/2–29/2 ħ. Theγ-decay pattern between the two bands is established in the crossing region and analysed in terms of a moderate shape difference between them. A theoretical estimate of the size of the interaction strength between the two bands is presented and compared to the experimental value. The observed band structure in163Tm is very similar to that of167Lu which has 2 protons and 2 neutrons in addition. This observation is discussed in relation to the similarity of the yrast bands of the two even-even “core” nuclei162Er and166Yb, for which theγ-transition energies are identical within ∼0.2 keV below the vi13/2 crossing.
    Type of Medium: Electronic Resource
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