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  • 1990-1994  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neural transmission 81 (1990), S. 147-152 
    ISSN: 1435-1463
    Keywords: Benzodiazepines ; diazepam ; operant behaviour ; decision making ; secondary stimulus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Studies of the behavioural effects of benzodiazepines have focused in particular on situations with negative secondary stimuli, i.e., stimuli signalling negative primary events such as punishment or non-reward. The general result is that benzodiazepines attenuate behavioural reactions to this type of stimuli. The aim of the present study was to investigate if there are any differences between positive and negative secondary stimuli in this respect. Rats were treated with diazepam in a modified Skinner box with two levers. One of the levers always gave a small reward. A lamp being ON or OFF was used as a secondary stimulus indicating if the other lever would give a large or no reward. Pretreatment with diazepam (1.0 mg/kg) did not act differently on the response to the positive or negative secondary stimulus. The main effect was a general attenuation of optimal responding with a concomitant decrease in water intake. An alternative hypothesis stating that benzodiazepines alter the reactivity to secondary stimuli more in general is supported.
    Type of Medium: Electronic Resource
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