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  • 1990-1994  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Immunogenicity and regenerative potential of acellular nerve allografts to repair peripheral nerve in rats and rabbits (1994)
    Springer
    Acta neurochirurgica 126 (1994), S. 158-164 
    Details
    ISSN: 0942-0940
    Keywords: Peripheral nerve ; nerve graft ; basal lamina ; immunogenicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study describes the ability of acellular nerve allografts (genetically different) to repair injured peripheral nerve in rats and rabbits. We recently reported the regeneration supporting potential and immunogenicity of acellular nerve allografts in rats7. The present study extends our previous work and quantitates the extent of axonal regeneration through various nerve grafts in rats. In addition, the use of longer nerve grafts to repair rabbit peripheral nerve is described. Inbred strains of Fischer and Buffalo rats and New Zealand white and Dutch rabbits were used. Acellular grafts were prepared by repeated freezing and thawing of in situ degenerated nerves. Nonfrozen predegenerated nerves were used as cellular grafts for comparison. Nerve isografts (genetically identical) were also performed. The graft length was 2.0 cm in rats and 4.0 cm in rabbits. In both rats and rabbits the cellular isografts showed the most rapid regeneration and target muscle innervation. The cellular allografts were invariably rejected and only showed limited regeneration. In contrast, acellular allografts, in spite of their mild immunogenicity, allowed significant regeneration through them. It is concluded that acellular nerve allografts are capable of supporting axonal regeneration because of their reduced immunogenicity, and thus can be used to bridge nerve gaps after nerve injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476427
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Morphological study of lectin binding in the rabbit temporomandibular joint disc (1991)
    Springer
    Journal of molecular histology 23 (1991), S. 132-142 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Glycoconjugates of the extracellular matrix are important for the normal mechanical functions of connective tissue structures such as the temporomandibular joint disc. Since lectins are known to bind to sugar residues with high affinity, a variety of lectins were used to study the presence and distribution of glycoconjugates in the temporomandibular joint disc. Discs were removed from 6 to 8-month-old rabbits and either sectioned in a cryostat and processed for light microscopy or fixed in 2% glutaraldehyde and processed for electron microscopy. The frozen sections were incubated with fluorescein- or peroxidaseconjugated lectin solutions. Ultrathin sections mounted on grids were incubated with lectins combined with a colloidal gold marker system for electron microscopical study. Our results indicate thatCanavalia ensiformis agglutinin (ConA) showed little or no binding to the discal tissue.Triticum vulgaris agglutinin (WGA) andMacluras pomifera (MPA) were bound strongly to both the synovium and the extracellular matrix and WGA also bound to the territorial matrix of chondrocyte-like cells.Glycine max andArachis hypogoea agglutinins (SBA and PNA), were localized in the synovium and extracellular matrix but to a lesser degree than WGA and MPA. WGA, MPA,Griffonia simplicifolia II andUlex europaeus were bound by discal fibroblasts. WGA was also localized in lysosomes of synovial A-cells (macrophages). The electron microscopical studies with lectins and colloidal gold marker systems indicated that some areas of the disc may be fibrocartilagenous as had been suggested by earlier immunohistochemical studies using monoclonal antibodies to characteristic glycosaminoglycans (GAGs) in cartilage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01047458
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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