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  • 1
    Electronic Resource
    Electronic Resource
    Spectroscopic detection of chemical intermediates in the reaction of para-substituted benzylamines with bovine serum amine oxidase (1993)
    s.l. : American Chemical Society
    Biochemistry 32 (1993), S. 2234-2241 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00060a015
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  • 2
    Electronic Resource
    Electronic Resource
    Comparative enantioselective pharmacokinetic studies of celiprolol in healthy volunteers and patients with impaired renal function (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 573-576 
    Details
    ISSN: 1432-1041
    Keywords: celiprolol ; renal failure ; pharmacokinetics ; enantioselective kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of the ß1-selective adrenergic antagonist (R,S)-celiprolol has been studied after oral administration of 200 mg celiprolol-HCl to 8 healthy volunteers and 8 patients with various degrees of impaired renal function. No significant difference was found between the two enantiomers in the control group or in the patients. In healthy volunteers an average of 9.8% of the dose of R-(+)-celiprolol and 9.5% of S-(-)-celiprolol was recovered unchanged in the urine. Renal impairment reduced the urinary excretion of both enantiomers to the same extent according to the severity of the uraemia, producing higher AUCs. Nevertheless, the terminal half-lives of the R- and S-enantiomers were not significantly different between the groups. Dosage reduction in patients with renal impairment does not seem to be necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316098
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  • 3
    Electronic Resource
    Electronic Resource
    Synthesis and evaluation of a new series of mechanism-based aromatase inhibitors (1992)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 35 (1992), S. 1588-1597 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00087a013
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  • 4
    Electronic Resource
    Electronic Resource
    An internal part of the chloroplast atpA gene sequence is present in the mitochondrial genome of Triticum aestivum: molecular organisation and evolutionary aspects (1990)
    Springer
    Current genetics 17 (1990), S. 523-528 
    Details
    ISSN: 1432-0983
    Keywords: Triticum aestivum ; Mitochondrial DNA ; Chloroplast DNA ; ATPase alpha subunit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary An internal part of the chloroplast atpA gene has been identified in the mitochondrial DNA of Triticum aestivum. It is located near the 18S-5S ribosomal genes and partially contained within a repeated sequence. Comparison of the transferred sequence with the original ct sequence reveals several nucleotide changes and shows that neither 5′ nor 3′ ends are present in the mt genome. No transcript of this region could be detected by Northern analysis. This sequence is present in mitochondrial genomes of other tetraploid and diploid species of Triticum, also in the vicinity of the 18S-5S ribosomal genes, suggesting a unique transfer event. The date of this event is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313082
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  • 5
    Electronic Resource
    Electronic Resource
    Nuclear genes control changes in the organization of the mitochondrial genome in tissue cultures derived from immature embryos of wheat (1992)
    Springer
    Current genetics 21 (1992), S. 515-520 
    Details
    ISSN: 1432-0983
    Keywords: Nuclear-cytoplasmic interactions ; Mitochondrial genome ; Chondriome variability ; Triticum aestivum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Although the mitochondrial genomes of the Chinese Spring and Aquila varieties of wheat are normaly similar in organization, this is not so in tissue cultures initiated from their immature embryos where the mitochondrial genomes of both are rearranged and in different, characteristic, ways. However, the mitochondrial genomes of tissue cultures of reciprocal F1 crosses between these varieties were almost identical to one another, showing that nuclear genes control the rearrangement processes. These rearrangements are either due to the appearance of new structures or else result from changes in the relative amounts of subgenomic components. The severe reduction in the amount of certain molecular configurations in tissue cultures from reciprocal crosses is probably due to the presence of dominant information in the Aquila nuclear genome. Data obtained from tissue cultures initiated from F2 embryos of the cross Aquila x Chinese Spring suggest that at least two complementary genes are involved in this control. In contrast, the presence of new molecular arrangements appears to be under the control of a dominant allelic form of a Chinese Spring gene or genes. Thus, this study demonstrates that at least two sets of nuclear genes control the reorganization of the mitochondrial genome which occurs when tissue cultures are initiated from the immature embryos of wheat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00351662
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  • 6
    Electronic Resource
    Electronic Resource
    Mesothelioma-like tumors of the pleura: a review of 72 autopsy cases (1994)
    Springer
    Journal of cancer research and clinical oncology 120 (1994), S. 331-347 
    Details
    ISSN: 1432-1335
    Keywords: Mesothelioma-like carcinosis ; Pseudo-mesotheliomatous tumor of the pleura ; Differential diagnosis ; Metastases ; Etiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The 72 mesothelioma-like tumors of the pleura (MLTP) found among 33 500 autopsy cases collected over more than 30 years are reviewed. MLTP have a worse prognosis than the 106 cases of pleural mesothelioma autopsied in our institutes with regard to survival time and metastatic spread. In MLTP, adenocarcinomas predominate with a wide range of histological and cytological variation and prominent development of connective tissue having its origin in the periphery of the lung. These intrapulmonary primary tumors often fulfill the criteria of pulmonary scar cancer. Etiologically, there is no correlation between the origin of this tumor and smoking or exposure to asbestos. The absence of mucus formation and glandular differentiation, together with the presence of spindle-shaped carcinoma components and strong mesothelial or stroma proliferation, can make the differential diagnosis between this tumor type and mesothelioma difficult. Immunohistological investigations were performed on 11 cases with antibodies against intermediate filament proteins, vascular endothelium, collagen IV, macrophage antigens, carcinoembryonic antigen (CEA), LeuM1, and the antibody BerEP4. Our investigation shows that a battery of several tumor markers, such as antibodies against LeuM1, CEA, and the antibody BerEP4, as well as staining with periodic acid/Schiff/diastase discriminate primary from secondary pleural neoplasms, whilst intermediate filament proteins alone are of little diagnostic value.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01247458
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  • 7
    Electronic Resource
    Electronic Resource
    Thymic carcinoma (1990)
    Springer
    Journal of cancer research and clinical oncology 116 (1990), S. 69-82 
    Details
    ISSN: 1432-1335
    Keywords: Thymic carcinoma ; Malignant thymoma ; Metastases ; Survival time
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Among 54 mediastinal tumours we examined in the past 20 years, there were 5 cases of primary thymic carcinomas, each with widespread metastases. Histological features in three cases were consistent with lymphoepithelioma-like carcinoma. One case showed an epidermoid pattern with keratotic pearls resembling Hassall bodies. One undifferentiated carcinoma developed from a cortical thymoma. Epstein-Barr virus could not be detected in tumour tissue with in situ hybridization. A review of the literature revealed only 94 well-documented cases of thymic carcinoma. Both thymic carcinomas and thymomas are neoplasms of the thymic epithelial cells, but thymic carcinomas are obviously histologically malignant and usually not associated with any parathymic syndromes. Epidermoid and lymphoepithelioma-like carcinomas are described along with special forms, such as small- and clear-cell carcinomas, basaloid, sarcomatoid, mucoepidermoid, and adenocystic carcinoma. Compared to the other forms, lymphoepithelioma-like carcinoma has a poor prognosis in regard to metastases and rate of survival. Some thymic carcinomas may develop from pre-existing thymomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01612643
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  • 8
    Electronic Resource
    Electronic Resource
    Characterization of two minicircular plasmid-like DNAs isolated from date-palm mitochondria (1994)
    Springer
    Current genetics 26 (1994), S. 535-541 
    Details
    ISSN: 1432-0983
    Keywords: Mitochondrial genome ; Plasmid-like DNA ; Date-palm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We report here the identification and characterization of two minicircular plasmid-like DNAs isolated from mitochondria of a moroccan date-palm variety. Both molecules were cloned and used as probes in Southern analyses of mitochondrial and total-cellular DNA. Evidence was obtained that these plasmid-like DNAs crosshybridized but did not show any homology to nuclear, chloroplastic, or main mitochondrial genomes. Sequence analysis revealed that both minicircles, 1 346- and 1 160-bp long, share several stretches of homology, the most important consisting of three identical clusters of lengths 42, 47 and 38 bp. In contrast, no major homology was observed with the other higher-plant plasmid-like DNAs reported so far. Sequence analysis also revealed the presence, in the same strand of one of the minicircles, of two open reading frames potentially encoding proteins 89 and 86 amino acids in length. Interestingly, Northern analyses, using single strands of each minicircle as probes, showed the presence of two transcripts hybridizing only with the strand bearing these two open reading frames. However, computer-assisted comparison of the predicted polypeptide sequences with a protein-sequence library failed to detect any significant homology to known sequences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309946
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  • 9
    Electronic Resource
    Electronic Resource
    Organ/tissue-specific changes in the mitochondrial genome organization of in-vitro cultures derived from different explants of a single wheat variety (1992)
    Springer
    Theoretical and applied genetics 85 (1992), S. 1-8 
    Details
    ISSN: 1432-2242
    Keywords: Wheat ; Somatic tissue culture ; Mitochondrial DNA ; Chondriome variability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We have previously shown that the mitochondrial genome of long-term tissue cultures prepared from immature embryos of several varieties of cultivated wheat underwent variety-specific rearrangements resulting from either changes in the relative amounts of subgenomic components or from the appearance of novel genomic configurations. In the present work, both categories of rearrangements were studied in long-term tissue cultures initiated from other explants (shoot meristem, young leaf base, young root tip, immature inflorescence) of the same wheat variety (Chinese Spring) and were compared to those previously obtained with immature embryo cultures. Two main patterns of reorganization were found in a region of the mitochondrial genome known to be hypervariable in structure. In addition, some of the novel subgenomic configurations were obviously organ/tissue-specific whereas others were present in more than one type of organ. In several instances, the age of culture was found to determine the degree of mitochondrial DNA rearrangement. The data presented in this study strengthen the hypothesis of an association between a particular organization of the mitochondrial genome in tissue culture and its regeneration capacity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223837
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  • 10
    Electronic Resource
    Electronic Resource
    Multiple patterns of mtDNA reorganization in plants regenerated from different in vitro cultured explants of a single wheat variety (1992)
    Springer
    Theoretical and applied genetics 85 (1992), S. 9-14 
    Details
    ISSN: 1432-2242
    Keywords: Wheat ; Somatic tissue culture ; Regenerated plants ; Mitochondrial DNA ; Chondriome variability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We have previously shown that tissue cultures derived from various explants of the wheat variety Chinese Spring exhibit organ/tissue-specific changes in the organization of their mitochondrial genome. The aim of this work was to study the influence of passage out of in-vitro culture, and subsequent plant regeneration, on the in vitro “induced” reorganization of this genome. In all cases but one, subgenomic configurations present in both the donor parent and the tissue culture were evident, in corresponding regenerated plants. The presence, in regenerated plants, of subgenomic configurations found in tissue culture but undetectable in the donor parent appeared to be both timeand organ/tissue-dependent. Moreover, when present, these novel organizations were not systematically found in all regenerated plants. Finally, novel subgenomic configurations were specifically detected after passage out of in-vitro culture. As these results were obtained from a single plant variety, they clearly confirm the extreme plasticity of mitochondrial genome structure in response to in-vitro culture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223838
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