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  • 1
    Electronic Resource
    Electronic Resource
    Circadian variation of blood pressure in patients with diabetic nephropathy (1992)
    Springer
    Diabetologia 35 (1992), S. 1074-1079 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 (insulin-dependent) diabetes mellitus ; diabetic nephropathy ; ambulatory blood pressure ; circadian ; variation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The association between diurnal blood pressure variation and diabetic nephropathy was assessed in four groups of Type 1 (insulin-dependent) diabetic patients who underwent 24-h ambulatory blood pressure monitoring using an oscillometrie technique. Patients with nephropathy, who had never been treated for hypertension (group D3,n = 13), were individually matched for age, sex and diabetes duration to a group of microalbuminuric patients (D2,n = 26), to normoalbuminuric patients (D1,n = 26) and to healthy control subjects (C,n = 26). Group D3 was also compared to patients with advanced nephropathy receiving treatment for hypertension, mainly a combination of angiotensin converting enzyme inhibitors, metoprolol and diuretics (D4,n = 11). In group D3 24-h diastolic blood pressure (85 ± 8 mm Hg) was comparable to the results obtained in D4 (85 ± 8 mm Hg) but significantly higher than in D2 (78 ± 7 mm Hg), D1 (73 ± 7 mm Hg) and C (73 ± 7 mm Hg,p 〈 0.05, Tukey's test). The night/day ratio of diastolic blood pressure was higher in D3 (86 ± 5 %) and D2 (85 ± 7%) than in C (80 ± 7 %,p 〈 0.02). This ratio was also elevated in group D4 (94 ± 8%) compared to D3 (p 〈 0.05) corresponding to a marked smoothing of the diurnal blood pressure curve. The 24-h heart rate (beats per min) was significantly elevated in D3 (84 ± 8) and D2 (80 ± 10) compared with C (73 ± 11,p 〈 0.05 Tukey's test), suggesting the presence of parasympathetic neuropathy In conclusion the normal circadian variation of blood pressure was moderately disturbed in a group of microalbuminuric patients and patients with less advanced overt nephropathy. Patients with advanced diabetic nephropathy receiving antihypertensive therapy showed a marked reduction of nocturnal blood pressure fall, which can only be identified by the application of ambulatory blood pressure measurements to verify the 24-h effectiveness of blood pressure control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02221684
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  • 2
    Electronic Resource
    Electronic Resource
    Electronic degrees of freedom and unimolecular rate constants in metal clusters (1994)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 101 (1994), S. 10481-10484 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We calculate the modifications of the unimolecular rate constants for free metallic clusters due to thermally exited electronic degrees of freedom. The effect is essentially taken into account by substituting Helmholtz's free energy of the electronic system for the ground state energy. The activation energy pertaining to the electronic ground states of the mother and daughter cluster is then replaced by the first difference in Helmholtz's free energy. © 1994 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.467866
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  • 3
    Electronic Resource
    Electronic Resource
    Scattering mechanisms and defects in InP epitaxially grown on (001) Si substrates (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 76 (1994), S. 4705-4712 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Carrier concentration and mobility of unintentionally doped InP layers, grown directly on Si using metal-organic vapor-phase epitaxy, have been studied. The formation of antiphase domains (APDs) was found to depend on annealing of the Si substrate in an AsH3 flow prior to epitaxial growth. Dislocation densities determined by the wet chemical delineation technique were (8±1)×107 cm−3, seemingly uncorrelated to APDs in the layers. In addition to a shallow donor and a compensating acceptor, a deep donor was observed affecting the temperature dependence of the free-electron concentration between 77 and 300 K. The electron mobility in this temperature range could be described in terms of the scattering mechanisms which are dominant in homoepitaxial InP, namely, scattering due to polar optical phonons, to ionized impurities, and to space charges. Electron scattering due to either of these mechanisms was strongly influenced by the occurrence of antiphase boundaries (APBs). The space-charge density as well as the degree of compensation of the epitaxial layers increases with the density of APBs. Degraded 300 K mobilities were obtained indicating the effect of local stress at the APB.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.358445
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  • 4
    Electronic Resource
    Electronic Resource
    Computer controlled probe diagnostic system and applications in a magnetized laboratory plasma (1994)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 65 (1994), S. 2615-2622 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A computer controlled acquisition and evaluation system for electrostatic probes is presented. Fully automatic evaluation of the probe characteristics yields electron temperature, plasma potential, and density during the recording. Two-dimensional probe positioning is accomplished with stepping motors. The system is characterized by 12-bit probe current resolution and extremely wide probe voltage range (±130 V). It is tested in a collisionless argon magnetoplasma and compared to standard wave diagnostic techniques for magnetized plasmas, i.e., the resonance cone technique. The influence of the probe radius on the electron current in a magnetized plasma is studied experimentally. The two techniques yield identical density and temperature values within 20% accuracy and therefore show the reliable applicability of the automatic evaluation system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1144660
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  • 5
    Electronic Resource
    Electronic Resource
    Intrathecal Synthesis of Anti-Borrelia burgdorferi Antibodies in Neuroborreliosis: a Study with Special Emphasis on Oligoclonal IgM Antibody Bands (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 37 (1993), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Pre- and post-treatment (up to 3–26 months after antibiotic therapy) humoral immune responses were investigated in five neuroborreliosis patients. Anti-Borrelia (B.) burgdorferi IgG and IgM antibodies in CSF and serum were quantitated by capture ELISA. Agarose gel isoelectric focusing (AIF) and protein blotting were used to detect oligoclonal IgG and IgM bands as well as oligoclonal anti-B. burgdorferi IgG and IgM antibodies. These latter components were visualized by transfer to antigen-coated membranes (immunoblot) and immunoenzymatic staining. By ELISA, intrathecal anti-B. burgdorferi IgG and IgM antibody synthesis was detected in all initial specimens and continued 3–26 months after antibiotic therapy in four and three cases, respectively. AIF with protein blotting showed oligoclonal bands of total IgG as well as total IgM in the initial CSF specimens of all patients and persistence of such components occurred in four and five cases, respectively. By AIF and immunoblot, oligoclonal anti-B. burgdorferi IgG and IgM antibody bands could be detected in the CSF of every patient. IgG antibody bands were present in all initial CSF samples. The first specimen of one patient was negative for IgM antibody bands but such components appeared 3 weeks later. Oligoclonal CSF anti-B. burgdorferi IgG antibody components persisted over the entire follow-up periods in all but one case where they disappeared 6 weeks after treatment. The oligoclonal IgM antibodies in CSF vanished in two cases (after being present up to 4 and 11 months after antibiotic therapy) while they persisted over the entire (3–6 months after antibiotic therapy) follow-up periods in three cases. The specificity of the IgM antibody immunoblot technique was corroborated by control experiments, including antibody absorption studies and use of 41 kDa flagellar antigen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1993.tb02566.x
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  • 6
    Electronic Resource
    Electronic Resource
    Lyme Arthritis: Oligoclonal Anti-Borrelia burgdorferi IgG Antibodies Occur in Joint Fluid and Serum (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 33 (1991), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The antibody response to Borrelia (B.) burgdorferi, and to measles virus as control antigen, was analysed by agarose isoelectric focusing (AIF) and immunoblot of joint fluid and serum from 10 patients with Lyme arthritis and 10 controls with rheumatoid arthritis. Among the Lyme arthritis patients, six had oligoclonal anti-B, burgdorferi IgG antibody bands in joint fluid and Corresponding serum, one patient had oligoclonal antibody bands in joint fluid only and also an elevated B. burgdorferi IgG in joint fluid to serum antibody ratio as evidence of intra-joint production of specific antibodies, and the remaining three patients were negative for oligoclonal-specific antibody bands. Absorption with B. burgdorferi imagen confirmed the specificity of the ofigoclonal antibody bands. They comigrated only partially on AIF with oligoclonal bands of total IgG and the specificity of most oligoclonal IgG in joint fluid and serum in Lyme arthritis remains undefined. Among the controls, no anti-B, burgdorferi IgG antibodies were detected by AIF and immunoblot. Instead. 9 of the 10 rheumatoid arthritis patients had oligoclonal anti-measles IgG antibody bands which were restricted to the joint fluid in three of them, indicating local production. We conclude that Lyme arthritis is often accompanied by an oligoclonal specific antibody response in joint fluid and serum simultaneously, and occasionally by intrasynovial synthesis of oligoclonal-specific antibodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1991.tb02492.x
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  • 7
    Electronic Resource
    Electronic Resource
    Distribution of serum IgE in children and adolescents aged 7 to 16 years in Copenhagen, in relation to factors of importance (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 47 (1992), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The distribution of total serum-IgE and factors of importance for the level of IgE was studied in a random sample of 508 children and adolescents, aged 7–16 years, from Copenhagen. A detailed history about asthma, rhinitis, dermatitis and urticaria was obtained, and a physical examination, skin prick test with 9 common allergens, lung function test, bronchial challenge with inhaled histamine and exercise, and measurement of IgE (kU/1) were performed. The distribution of IgE among children and adolescents was found to exhibit a log normal distribution and a positive skin prick test, allergic symptoms, a family history of allergic diseases, age and smoking were found to be significantly related to an increased level of IgE. No relationship was found between increased bronchial responsiveness and IgE. The geometric mean of “normal” values of IgE (* 1 SD and *2 SD) of the Danish children and adolescents was 18 kU/1 (*4.7, * 18.2), suggesting that normal IgE values were within 330 kU/1. Measurement of IgE as the only screening for allergic disease is unreliable, as the predictive value of an elevated IgE in population samples was found to be 50%, whereas misclassification (1-specificity) of asymptomatic subjects as allergic because of an increased IgE was low (4%). In conclusion, total IgE is highly influenced by allergen skin reactivity. Further, this study suggests that normal IgE values were within 330 kU/1, although the range was wide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1992.tb00669.x
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  • 8
    Electronic Resource
    Electronic Resource
    Pulmonary function in adolescents with childhood asthma (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 48 (1993), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to determine the pulmonary function in former and present asthmatics. We examined 77 persons aged 12–24 years, classified into four groups: 1) healthy subjects (controls) (n= 19), 2) former asthmatics (n= 19), 3) present mild asthmatics (n= 20), and 4) present severe asthmatics (n= 19). Although exhibiting no respiratory symptoms, former asthmatics had reduced airflow values measured by FEV, (median (range) 89.7 (83–99) vs 101.4 (91–110)) and MEF25 (76.5 (68–94) vs 103.0 (97–124)), as compared with controls. Furthermore, former asthmatics had significantly increased PEF variability, as compared with controls, whereas no significant differences were found in static lung parameters, i.e. total lung capacity and residual volume, as compared with controls. In conclusion, former asthmatics, although now exhibiting no respiratory symptoms, were found to have obstructive airflow limitation, increased bronchial responsiveness, and normal lung volumes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1993.tb00727.x
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  • 9
    Electronic Resource
    Electronic Resource
    Observation of quantum supershells in clusters of sodium atoms (1991)
    [s.l.] : Nature Publishing Group
    Nature 353 (1991), S. 733-735 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The semiclassical theory of Balian and Bloch4 was extended and applied to idealized spherical sodium droplets with somewhat diffuse potential walls6. A quantum beat was found in the shell structure, with a pronounced minimum being predicted around size N - 1,000. The semiclassical results were ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/353733a0
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  • 10
    Electronic Resource
    Electronic Resource
    Management of Peutz-Jeghers syndrome (1994)
    Springer
    International journal of colorectal disease 9 (1994), S. 177-179 
    Details
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les patients danois porteurs d'un syndrome de Peutz-Jeghers sont enregistrés dans le registre danois des polyposes. Nous avons débuté un nouveau programme de follow-up en nous basant sur les données récentes de la littérature et sur nos propres cas. Le suivi a été ajusté sur la vitesse de croissance des polypes alors que chez les patients asymptomatiques et qui présentaient un taux de croissance lent, les contrôles ont pu être espacés. Le programme comporte des endoscopies hautes et basses du tractus gastro-intestinal, un transit baryté suivi et, dans certains cas, chez des porteurs de polypes étendus ou asymptomatiques, une laparotomie a été réalisée avec une entéroscopie pertopératoire totale complétée par des polypectomies. Un examen de la cavité pelvienne, un frottis cervical, une palpation du sein et des testicules ont été réalisés chez toux les patients âgés de plus de 30 ans.
    Notes: Abstract Danish patients with Peutz-Jeghers syndrome are registered in the Danish Polyposis Register. We have initiated a new follow-up programme based on recent literature including our own cases. This has been adjusted to the regrowth rate of the polyps whereby patients with no symptoms and low regrowth rate are followed with few examinations. The programme includes upper and lower gastrointestinal endoscopy, small bowel enema and in cases with large or symptomatic polyps, laparotomy with intraoperative total enteroscopy with polypectomy as required. Pelvic examination, cervical smear, breast and testicular examination are carried out after the age of 30 years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00292244
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