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  • 1
    Electronic Resource
    Electronic Resource
    Plasma lipid-bound sialic acid alterations in neoplastic diseases (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 91-94 
    Details
    ISSN: 1420-9071
    Keywords: Lipid-bound sialic acid ; cancer patients ; tumor marker ; non-malignant diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Plasma lipid-bound sialic acid (LSA) was assayed in normal volunteers, patients with non-malignant diseases, and a variety of cancer patients. Mean plasma LSA in 50 normal volunteers, 16 patients with non-malignant diseases, 54 breast cancer, 17 lung cancer, 15 colon cancer, 7 ovarian cancer, 5 prostate cancer, 4 leukemia, 4 gastrointestinal, 3 thyroid cancer, 3 pancreas cancer and 2 adrenal cancer patients were 17.7, 23.2, 58, 85, 56.7, 46.2, 56.7, 53.3, 31.1, 33.2 and 119.5 mg/dl, respectively. None of the normal volunteers had elevated plasma LSA values. Plasma LSA level was not significantly different in male and female volunteers. Two patients with rheumatic arthritis had LSA values slightly elevated over the mean + 2 SD for the normal volunteers. Two out of 114 different cancer patients had plasma LSA levels within normal range exhibiting 98.2% sensitivity of the assay. Plasma LSA, which is relatively simple to assay, may be used as a tumor marker in wide variety of neoplastic diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955427
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  • 2
    Electronic Resource
    Electronic Resource
    Monte Carlo simulation of the solid to super liquid phase transition of Langmuir monolayers using cross-section potentials (1993)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 99 (1993), S. 8194-8199 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A cross-section potential which models the interaction of two planar objects of prescribed shape is developed and used to model the interactions of amphiphiles in vertical phases of Langmuir monolayers. The results of Monte Carlo simulations of an isobaric–isothermal ensemble show qualitative agreement with experiment. The model system undergoes a continuous, bound-to-free rotator transition between phases of the same symmetries as the solid (S) and super liquid (LS) phases exhibited by fatty acid films.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.465646
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Regional myocadial blood flow and cardiac mechanics in dog hearts with CO2 laser-induced intramyocardial revascularization (1990)
    Springer
    Basic research in cardiology 85 (1990), S. 179-197 
    Details
    ISSN: 1435-1803
    Keywords: myocardial ischemia ; revascularization ; laser ; systolicperfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Laser-induced intramyocardial revascularization (LIR) has been used to promote direct communications between blood within the ventricular cavity and that of the existing myocardial vasculature in an attempt to increase perfusion in patients with ischemic heart discase. This study was conducted to measure the effects of LIR channels on regional myocardial flood flow (microspheres), cardiac mechanics (sonomicrometers), and myocardial tissue pressures in 18 dogs. Under baseline hemodynamic conditions (mean HR=165.2±11.4 bpm, LVP=123.6±22.9/4.0±1.8 mmHg, AoP=112.8±27.1/77.0±22.5 mmHg), myocardial blood flow in laser-treated tissue (mean =1.11±.10 cc/min/gm before laser; .71±.19 cc/min/gm after laser) was reduced as compared to blood flow in control tissue (mean=1.12±.15 cc/min/gm before laser; 1.25±.22 cc/min/gm after laser). Regional myocardial systolic shortening (11.32%±3.82% before laser; 7.49%±2.86% after laser) was decreased by 33%. During simultaneous reversible ligation of the LAD and LCCA for 2 min, when intramyocardial channels represented the only tissue access for the injected microspheres, blood flow in laser-treated tissue was not increased above that of the control non-lasered tissue. However, regional blood flow was greater in laser-treated ischemic tissue (mean=.61±.12 cc/min/gm) than in untreated ischemic areas (mean=.04±.03 cc/min/gm) when left ventricular pressure (LVP) was acutely elevated (mean SLVP=207.0±16.1 mmHg). Using these measurements, a model is proposed to predict regional systolic pressure gradients between the left ventricular cavity and coronary intramyocardial vasculature required to permit restoration of blood flow to ischemic myocardium. We conclude that improved perfusion via laser-induced intramyocardial channels does not occur in otherwise normal myocardium exposed to acute coronary ligation and only small improvements in perfusion are noted when LVP is significantly elevated. Consideration of further clinical application of this approach is seriously cautioned awaiting additional experimental studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01906971
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  • 4
    Electronic Resource
    Electronic Resource
    Variability in the pharmacokinetics of cyclophosphamide, methotrexate and 5-fluorouracil in women receiving adjuvant treatment for breast cancer (1994)
    Springer
    Cancer chemotherapy and pharmacology 33 (1994), S. 472-476 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. A total of 23 women with stage II breast cancer receiving adjuvant cyclophosphamide, methotrexate and 5-fluorouracil had detailed pharmacokinetic monitoring performed on the first and third courses of therapy. The area under the concentration time curve (AUC) of each of these three drugs varied by a factor of 3–4 among patients. No systematic change in pharmacokinetics between the first and third courses was seen for cyclophosphamide, methotrexate or 5-fluorouracil, and the mean AUC for each of the three drugs did not change. However, significant intrapatient variability in drug pharmacokinetics was observed for all three drugs such that the AUC, clearance and half-life in an individual on the third course could not be reliably predicted from data generated on the first course. On the basis of these results, cyclophosphamide, methotrexate, and 5-fluorouracil pharmacokinetic data from one treatment would not be useful information from which the doses for subsequent courses could be determined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686503
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Variability in the pharmacokinetics of cyclophosphamide, methotrexate and 5-fluorouracil in women receiving adjuvant treatment for breast cancer (1994)
    Springer
    Cancer chemotherapy and pharmacology 33 (1994), S. 472-476 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A total of 23 women with stage II breast cancer receiving adjuvant cyclophosphamide, methotrexate and 5-fluorouracil had detailed pharmacokinetic monitoring performed on the first and third courses of therapy. The area under the concentration time curve (AUC) of each of these three drugs varied by a factor of 3–4 among patients. No systematic change in pharmacokinetics between the first and third courses was seen for cyclophosphamide, methotrexate or 5-fluorouracil, and the mean AUC for each of the three drugs did not change. However, significant intrapatient variability in drug pharmacokinetics was observed for all three drugs such that the AUC, clearance and half-life in an individual on the third course could not be reliably predicted from data generated on the first course. On the basis of these results, cyclophosphamide, methotrexate, and 5-fluorouracil pharmacokinetic data from one treatment would not be useful information from which the doses for subsequent courses could be determined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686503
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Sequence analysis of temperature sensitive and “neuraminidase-tolerant” mutants of Newcastle disease virus (strain Beaudette C) (1991)
    Springer
    Archives of virology 119 (1991), S. 141-146 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nucleotide sequence analysis of temperature sensitive and “neuraminidase-tolerant” mutants of Newcastle disease virus has identified sites in the haemagglutinin-neuraminidase protein which may be important in folding and function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01314330
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