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  • 1
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract While the role of the H-2 complex in the resistance to virally induced tumors has been extensively studied, little is known about its influence on the development of epithelial tumors of non-viral etiology, although such tumors are most prevalent in humans. Therefore, we analyzed the role of the H-2 complex in susceptibility to mammary tumors induced by hormonal stimulation from heterotopic hypophyseal isografts in H-2 congenic strains from C57BL/10, BALB/c, and 020/A backgrounds. This method of induction allows an assessment of the effect ofH-2 genes on the function of various organs involved in this process. We found that the tumor susceptibility genes map to two segments: PE-S, and to the right of S. The mechanisms by which the H-2 complex affects the induction of mammary tumors in C57BL/10 congenic strains seem to include an influence on several factors involved in the hormonal stimulation, because the susceptible B10 congenic strains have higher plasma levels of prolactin and the H-2 complex also affects the growth of hypophyseal isografts. Their size correlates with tumor development in individual mice in the resistant C57BL/10 congenic strains. We reported previously H-2-dependent differences in levels of the estrogen receptor in hypophysis. For this study, we measured the levels of estrogen receptors in uteri to assess the tissue specificity of this effect of H-2. However, no influence of the H-2 complex on estrogen receptor levels was observed in uteri. Strains from BALB/c and 020 backgrounds developed mammary tumors much earlier than the B10 congenic strains, indicating a strong influence of non-H-2 genes.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 81 (1991), S. 0 
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract: A novel, apparently acid-stable cytochrome has been purified from Leptospirillum ferrooxidans in which it probably functions in the ‘downhill’ transfer of electrons from ferrous iron. It appeared to comprise a single polypeptide of apparent Mr 17.9 kDa as determined by SDS-PAGE. Non-denaturing PAGE showed this to be the approximate size of the native protein. The oxidized cytochrome showed a broad absorption maximum at 422 nm and was readily reduced with dithionite or ferrous iron to give a form with absorption maxima at 440 and 579 nm. A mid-point potential of +680 mV at pH 3.5 was determined. Iron and zinc were found at concentrations approaching one atom of each per cytochrome molecule.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract The effect of improved metabolic control on the clinical periodontal condition and the subgingival microflora of diseased and healthy periodontal pockets in 6 ambulatory insulin-dependent diabetes mellitus (IDDM) patients was prospectively studied. Duplicate measurements with a time-interval of 3 days were made every 4 moths for assessment of the metabolic status, the clinical periodontal condition and the subgingival microflora. During the study, patients maintained personal oral hygiene measures as they usually did before the study. Neither supplementary dental prophylaxis nor oral hygiene measures were applied during the investigation. Long-term metabolic control (HbA1c) improved significantly with intensive conventional insulin treatment. Gingival redness decreased significantly whereas gingival swelling showed a not significant trend to decrease. It is suggested that microvascular changes associated with improved metabolic control in diabetes mellitus may mediate the observed change in gingival redness. No effect could be demonstrated for probing pocket depth, probing attachment level, bleeding on probing and the plaque index. Statistical analysis of the effect of improved metabolic control on the subgingival microflora revealed that only the % of streptococci increased significantly in diseased periodontal pockets. In general, no significant changes were found in either healthy or diseased pockets with regard to the bacterial flora associated with periodontal disease. The results of the present study indicate that improved metabolic control in IDDM patients may have no potential impetus for an improved clinical periodontal condition nor on the subgingival bacterial flora. It is concluded that the periodontal condition in IDDM patients may only ameliorate when local oral hygiene measures are applied.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 17 (1990), S. 0 
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract The purpose of the present study was to investigate the effect of mechanical oral hygiene procedures on bleeding on probing in relation to age and periodontal status. The study was carried out on 49 indivuals divided into 7 experimental groups according to age and having been either treated for destructive periodontal disease or having an intact healthy periodontium. In order to eliminate any pre-existant gingival inflammation, all subjects received a carefully controlled oral hygiene program. At the start of the experiment, all subjects were instructed to abstain from oral hygiene procedures for 24 h. Thereafter, clinical baseline measurements were carried out, including bleeding on probing (BOP) using a standardized probing pressure. Next, all subjects cleaned their teeth according to their normal oral home care protocol using a multitufted toothbrush, toothpicks and interdental brushes. BOP scores were again assessed 30 min after completed tooth cleaning procedures. The results revealed a significant increase in BOP after the mechanical oral hygiene procedures in every individual in all experimental groups (p 〈0.05). Further analysis showed that the increase in BOP was independent of the periodontal status of the subjects. However the BOP scores after mechanical oral hygiene procedures were higher in the young age groups. It was concluded that the diagnostic predictability of BOP in the treatment of periodontal diseases might be affected by temporarily elevated BOP scores shortly after mechanical oral hygiene procedures.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 75 (1994), S. 5574-5576 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A computational simulation of a dispersion of iron particles undertaken to study the influence of the magnetostatic interactions on the microstructure of a particle ensemble is reported herein. The simulation considers an equilibrium state derived from an initial random state by the force-bias Monte Carlo technique. This method favors particle moves in the direction of the magnetostatic forces. A three dimensional ensemble in zero field and a saturating field are studied. An approach which takes into account the magnetostatic interactions between clusters by allowing Monte Carlo moves of whole clusters has been developed. This approach leads to the formation of extended networks consisting of particles in strongly bound clusters which themselves interact and give rise to an extended network. This is similar to the long-range order observed in practical dispersions. The structure analysis is found to characterize the local order, being especially sensitive to anisotropy in the order produced by an aligning field.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Grass and forage science 46 (1991), S. 0 
    ISSN: 1365-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Ryegrass, some white clover cultivars (Grasslands Huia, Trifo, Barbian and Luclair) and lotus were grown in the presence of mineral nitrogen and at a range of phosphorus (P) supply. Ryegrass had the highest leaf inorganic P concentrations on a dry weight basis, and lotus the lowest. In the clovers and lotus shoot yield was correlated with inorganic P concentration; it was not correlated in ryegrass, although this was possibly a result of the stage of development of ryegrass when it was harvested. Ryegrass was always more efficient than the legumes in acquiring P and growing rapidly. When inorganic P concentration was expressed on the basis of DNA, lotus had concentrations intermediate between that of ryegrass and the clovers, i.e. lotus had at least as much inorganic P per unit of DNA as white clover. It is suggested that although lotus is more efficient than white clover in terms of the concentration of inorganic P on a dry weight basis, the amount of inorganic P required per ‘module of metabolism’ (or cell), is similar. Lotus also has larger cells than white clover and the relatively greater efficiency of lotus may lie at least partly in its ability to achieve an equivalent leaf area or weight with fewer cells, i.e. cytology contributes to efficiency.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Grass and forage science 47 (1992), S. 0 
    ISSN: 1365-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Two cultivars of white clover (Ladino and Kent Wild White) and two cultivars of lotus (Grasslands Maku and G4703) were grown in pots of soil at low to moderate levels of phosphorus (P) supply. Nitrogen supply was by fixation. Cell size and nitrogen, phosphorus and chlorophyll content per cell were estimated from samples of leaf tissue. Maku lotus had larger cells and higher cellular contents of metabolites than the clovers. These measurements support earlier suggestions that, compared with white clover, the higher P-efficiency (dry matter per unit of internal P) of Maku lotus may be explained by cytological factors without recourse to explanations based on differences in nutrient metabolism. The relatively large cells and high metabolite levels per cell of Maku lotus appear to arise from its creation as an artificial tetraploid.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Grass and forage science 49 (1994), S. 0 
    ISSN: 1365-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: White clover (Grasslands Huia) and lotus (Grasslands Maku) were grown in pots of soil at a range of phosphorus supply, and reliant on symbiotic nitrogen fixation (SN plants) or entirely on mineral nitrogen (MN plants). Shoots increased in weight with phosphorus supply. White clover MN shoots were bigger than those of SN plants except at the lowest level of phosphorus supply; lotus MN shoots were only bigger than SN shoots at the highest level of phosphorus supply. Leaf growth rate and size increased with phosphorus supply but were not significantly affected by the nitrogen treatments.Estimates of cell size were made by determining DNA concentration, by digestion of tissue followed by counting and by taking vinyl impressions of epidermal cell surfaces. Lotus cells are bigger than those of white clover. ‘Digested’ cell sizes were not significantly affected by changes in phosphorus supply. Epidermal cell size increased with phosphorus supply, but the relationship was weaker in SN than in MN plants. Methods which give values for ‘average’ cell size are capable of detecting large-scale differences, but methods able to resolve cell heterogeneity are necessary for an accurate picture of the relationship between leaf growth and cellular nutrition.Average concentrations of total and inorganic phosphorus on a DNA basis did not differ between the species, contrary to concentrations on a dry weight basis, indicating that differences in phosphorus efficiency can be partly explained on the basis of average differences in cell size. Differences in inorganic phosphorous on a DNA basis at higher levels of supply suggested an additional intrinsic difference in cellular accumulation of inorganic phosphorus between the two species.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 67 (1990), S. 4481-4483 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The origins of gyroremanent magnetization (GRM) in single domain particles are studied using a dynamic model based on the Landau–Lifschitz equation. The results show an asymmetry in the motion of the magnetic moment of a particle with three unequal axes of anisotropy. This asymmetry is interpreted in terms of an effective bias field which gives a good qualitative explanation of the origins of GRM.
    Type of Medium: Electronic Resource
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