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  • 1
    Electronic Resource
    Electronic Resource
    Modification of the reactivity of polyhydrides with Lewis acids. Synthesis and reactivity of {IrH5[P(iso-C3H7)3]2}2Cu(CF3SO3). X-ray crystal structure of {IrH2(MeCN)2[P(iso-C3H7)3]2}(BF4) (1990)
    s.l. : American Chemical Society
    Inorganic chemistry 29 (1990), S. 5000-5002 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00349a033
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  • 2
    Electronic Resource
    Electronic Resource
    Synthesis and characterization of the monomeric gallium monoamides tert-Bu2GaN(R)SiPh3 (R = tert-Bu, 1-adamantyl), Trip2MN(H)Dipp (M = Al, Ga; Trip = 2,4,6-iso-Pr3C6H2; Dipp = 2,6-iso-Pr2C6H3), and Trip2GaNPh2 (1993)
    s.l. : American Chemical Society
    Inorganic chemistry 32 (1993), S. 2557-2561 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00063a057
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  • 3
    Electronic Resource
    Electronic Resource
    Electrophysiological evidence for a spinal antinociceptive action of dipyrone (1994)
    Springer
    Inflammation research 41 (1994), S. 62-70 
    Details
    ISSN: 1420-908X
    Keywords: Dipyrone ; Metamizol ; Spinal cord ; Afferent fibres ; Inflammatory pain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Electrophysiological experiments in anesthetized cats and rats were performed in order to study the effects of dipyrone on single afferent fibers from the knee joint and on spinal cord neurons with knee joint input. The neurons were activated and/or rendered hyperexcitable by an acute inflammation in the knee joint. In the joint nerve in cats, intravenous dipyrone (25–100 mg/kg) reduced ongoing activity in 10/12 thinly myelinated afferents but only in 1/10 unmyelinated afferents; the responses to movements of the inflamed knee were reduced in 8/10 thinly myelinated but only in 3/10 unmyelinated units. The reduction of activity was significant 20–30 min after application and was maximal at 60–180 min. In the spinal cord of spinalized cats, intravenous dipyrone (25–100 mg/kg) reduced ongoing activity and/or responses to pressure onto the inflamed knee in 14/16 neurons and in non-spinalized rats similar effects were seen in 10/11 neurons. Effects on spinal cord neurons started 5–10 min after application and were maximal after 20–40 min. These data show pronounced suppression of inflammation-induced nociception by dipyrone and they suggest that the spinal cord is a major site of action of this compound.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01986396
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  • 4
    Electronic Resource
    Electronic Resource
    Disialoganglioside GD2 in human neuroectodermal tumor cell lines and gliomas (1991)
    Springer
    Acta neuropathologica 82 (1991), S. 45-54 
    Details
    ISSN: 1432-0533
    Keywords: GD2 ; Monoclonal antibodies ; Gliomas ; Ganglisides ; Medulloblastomas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Monoclonal antibodies (mAbs) recognizing the disialoganglioside II3(NeuAc)2GgOse3Cer (GD2) were produced by immunizing mice with the GD2-expressing neuroblastoma cell line LAN-1 and a prefusion boost with purified GD2 coupled to Salmonella minnesota. Two IgM mAbs were isolated which demonstrated high levels of reactivity (binding ratios in excess of 100) with GD2 by solid-phase radioimmunoassay and positivity in high-performance thin-layer chromatography (HPTLC) immunostain; only one (DMAb-20) was subsequently shown by analysis with a panel of defined ganglioside species to be specific for the minimum epitope of GD2, GalNAcβ1-4(NeuAcα2-8NeuAcα2-3)Gal-. DMAb-20 was used to evaluate the expression of GD2 by malignant glioma and medulloblastoma cell lines using cell surface radioimmunoassay, indirect membrane immunofluorescence, HPTLC immunostain, and densitometric analysis of extracted gangliosides from selected cell lines. Sixteen of 20 (80%) malignant glioma and 5 of 5 medulloblastoma cell lines reacted with DMAb-20; in agreement with previous studies, 5 of 5 neuroblastoma and 2 of 3 melanoma cell lines also reacted with DMAb-20. GD2 was proportionally increased in the glioma and medulloblastoma cell lines relative to levels in normal brain, as determined by densitometric analysis. In a phenotypic survey of malignant glioma biopsies, tumor cells in 24 of 30 (80%) cases stained positively with DMAb-20. Reactive astrocytes, both within and adjacent to tumors, were frequently intensely stained. Among the morphological variants of glioblastoma examined, the most intense staining with DMAb-20 was observed in neoplastic gemistocytes, with the weakest or absent staining in small cell glioblastomas. As GD2 is a commonly expressed surface antigen of gliomas and medulloblastomas, expression of which is retained in tissue culture, DMAb-20 will be useful in determining the functional role of GD2 in cell-cell interaction, adhesion, and invasion, and in defining altered growth control mechanisms of central nervous system neoplasms in in vitro models.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310922
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  • 5
    Electronic Resource
    Electronic Resource
    Transformations of chemically fixed liquid anhydrous ammonia by soil microorganisms (1991)
    Springer
    Biology and fertility of soils 11 (1991), S. 145-150 
    Details
    ISSN: 1432-0789
    Keywords: Nitrogen-15 ; Ammonia fixation ; Organic matter-fixed NH3 ; Clay-fixed NH inf4 sup+
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The application of liquid anhydrous NH3 to soil leads to chemical fixation of NH3 by organic matter and of NH inf4 sup+ by clay minerals. A laboratory study was conducted to ascertain the biological transformations of newly fixed liquid anhydrous 15NH3 in a Drummer silty clay loam by incubation of the 15N-labelled soil with glucose for 0, 7, 30, and 90 days and by sequential extraction of organic-matter-fixed 15NH3 with 0.15 M Na4P2O7, 0.15 M KOH, 0.1 M NaOH, and acidified dimethyl sulfoxide. About 16% of the 15NH3 injected was fixed, of which 52% was accounted for by clay fixation. The various humic fractions (fulvic acid, humic acid, and humin) were obtained, and the distribution patterns of the fixed 15NH3-N in these fractions were compared. The potential availability of the fixed 15NH3-N was also estimated. The percentage of the 15NH3 recovered as organic-matter-fixed 15NH3 decreased as the length of incubation increased (to 28% after 90 days); the decrease was attributed in part to an increase in the amount recovered as clay-fixed NH inf4 sup+ (from 52 to 64%). Changes in the distribution of the organic-matter-fixed 15NH3-N in the humic fractions included: (1) an increase in the relative amount of the fixed 15NH3 as humic acid in both the Na4P2O7 and KOH extracts, (2) an increase in the percentage of organic-matter-fixed 15NH3-N in the fulvic acid fractions as high-molecular-weight components (determined by dialysis) or as generic fulvic acid (determined by sorption-desorption from XAD-8 resin), and (3) an increase in the percentage of the organic-matter-fixed 15NH3 as humin. The potential availability of the organic-matter-fixed 15NH3-N decreased as the length of the incubation increased, from 22 to 4% over the 90-day incubation period, and was correlated significantly (0.05 level) with Na4P2O7-extractable N. These results suggest that organic-matter-fixed liquid anhydrous NH3 is initially more labile than the native soil N but becomes less labile with time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336380
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  • 6
    Electronic Resource
    Electronic Resource
    Mutactin, a novel polyketide from Streptomyces coelicolor. Structure and biosynthetic relationship to actinorhodin (1990)
    s.l. : American Chemical Society
    The @journal of organic chemistry 55 (1990), S. 1682-1684 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00292a053
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  • 7
    Electronic Resource
    Electronic Resource
    Dopamine Stimulates [3H]Phorbol 12,13-Dibutyrate Binding in Cultured Striatal Cells (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 58 (1992), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The effect of dopamine (DA) on the binding of [3H]phorbol 12,13-dibutyrate ([3H]PdBu) in cultured rat striatal cells was examined. DA maximally increased specific [3H]PdBu binding by 70 ± 10%, an increase comparable to that observed with norepinephrine (NE). This finding suggests that DA activates protein kinase C in cultured striatal cells, because increases in [3H]PdBu binding reflect translocation of protein kinase C. Half-maximal stimulation was observed with 10–6M DA. The peak response was observed at 2–3 min after addition of 10–4M DA, but [3H]PdBu binding was still increased above basal at 30 min. DA was not acting via an adrenergic receptor. Prazosin (10–6M) blocked the response to NE, suggesting mediation by an α1-adrenergic receptor, but had little effect on the response to DA. Conversely, the D1 receptor antagonist SCH-23390 (10–6M) blocked the response to DA, but only partially inhibited the response to NE. Morphine (10–6M) inhibited the response to DA by 46 ± 14%, but did not affect significantly the response to NE. The DA effect on [3H]PdBu binding is apparently independent of the increase in cyclic AMP seen on D1 receptor activation. Forskolin, apomorphine, and the D1 agonist SKF-38393 all increased cyclic AMP in striatal cells, but were less effective than DA in stimulating [3H]PdBu binding. The D2 agonist quinpirole was ineffective in stimulating either cyclic AMP or [3H]PdBu binding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1992.tb11343.x
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  • 8
    Electronic Resource
    Electronic Resource
    Theoretical investigation of minority carrier leakages of high-power 0.8 μm InGaAsP/InGaP/GaAs laser diodes (1994)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 65 (1994), S. 2260-2262 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We report a theoretical model that accurately describes the effects of minority carrier leakage from the InGaAsP waveguide into InGaP cladding layers in high-power aluminum-free 0.8 μm InGaAsP/InGaP/GaAs separate confinement heterostructure lasers. Current leakage due to the relatively low band-gap discontinuity between the active region and the InGaP barrier can be eliminated by employing laser diodes with cavity length longer than 500 μm. Experimental results for lasers grown by low-pressure metalorganic chemical vapor deposition are in excellent agreement with the theoretical model. © 1994 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.112738
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  • 9
    Electronic Resource
    Electronic Resource
    Local stoichiometry measurement of Y-Ba-Cu-O thin layers grown by metal organic chemical vapor deposition (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 75 (1994), S. 4092-4096 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Y-Ba-Cu-O thin films with different stoichiometry were grown by metal organic chemical vapor deposition on MgO and SrTiO3. The samples showed superconducting behavior in a wide range of average stoichiometry. However, energy dispersive x-ray spectroscopy (EDX) measurements show that best results can be obtained only in a small stoichiometry range. Critical temperatures of Tc(approximately-greater-than)89 K and critical current densities of jc (77 K)(approximately-greater-than)2×106 A/cm2 could be obtained with optimized stoichiometry. Spatially resolved EDX measurements show that copper tends to form precipitates on the layers if its average content exceeds 50 mol %, while yttrium is incorporated into the matrix if offered in excess.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.355987
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  • 10
    Electronic Resource
    Electronic Resource
    Frequency dependence of the transverse biased permeability in thin permalloy films : 37th Annual conference on magnetism and magnetic materials (1993)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 73 (1993), S. 5995-5997 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The frequency dependence of the transverse biased permeability μ't(f ) has been measured up to 250 MHz in thin (0.044 μm) and thick (2.1 μm) unpatterned sputtered permalloy films with uniaxial anisotropy. In these films, the initial permeability along the hard axis can be described by the classical eddy current damping model assuming uniform rotation. For both films, μ't at low frequency agrees reasonably well with Hoffman's ripple model assuming appropriate values for the structure factor. In the thin film, μ't(f ) is independent of frequency within experimental error up to at least 250 MHz. However, in the thick film μ't(f ) decreases more rapidly with frequency than can be explained by classical eddy currents, when the transverse bias field HB is not very large compared to the net anisotropy field. The value of HB at which μ't(f ) reaches a maximum amplitude is also found to increase monotonically with increasing frequency, also inconsistent with simple eddy current predictions. It is suggested that the formation of ripple walls leads to anomalous eddy current losses similar to that observed in bulk materials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.353498
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