ISSN:
1432-1440
Keywords:
Hypertension
;
Calcium
;
Parathyroid hormone
;
1,25-Dihydroxyvitamin D3
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Essential hypertension has been associated with disturbed calcium metabolism, but the available data are controversial. We measured parameters of calcium metabolism in groups of untreated male subjects (n = 78) with elevated diastolic blood pressure (101 ± 6 mmHg, mean ± SD) and age-matched male subjects (n=79) with low diastolic blood pressure (62 ± 4 mmHg). The participants of the study were drawn from a random population sample. Subjects with high diastolic blood pressure had significantly higher carboxy-terminal parathyroid hormone (PTH) plasma concentrations than controls with low diastolic blood pressure (median 114 vs. 43 pmol/l, P 〈 0.01). The 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations were comparable in both groups. Individuals with high diastolic blood pressure had significantly lower total serum calcium (2.41 ± 0.10 vs. 2.47 ± 0.10 mmol/l, mean ± SD; P 〈 0.01). PTH concentrations were correlated with diastolic pressure (r = −0.39, P 〈 0.001). The data are compatible with increased parathyroid activity despite unchanged concentrations of vitamin D metabolites in human hypertension.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00180741
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