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  • 1990-1994  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Antiproliferative effects on keratinocytes of a range of clinically used drugs with calmodulin antagonist activity (1993)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 128 (1993), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Thirty-two drugs, including some in use for a variety of clinical disorders, were examined for their ability to inhibit calmodulin activity in vitro. From these. 10 drugs were selected for their inhibition of calmodulin activity and examined for their ability to inhibit proliferation of rapidly dividing human keratinocytes. A significant correlation between antiproliferative activity and calmodulin antagonist potency was found. Of these drugs there were several, including miconazole. dequalininm chloride, bromocriptine and tamoxifen, whose use is well established and well documented. The potential use of these drugs (and others identified in this way) as antipsoriatic agents is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1993.tb15143.x
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Receptor Protein-Tyrosine Kinases and their Signal Transduction Pathways (1994)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Cell and Developmental Biology 10 (1994), S. 251-337 
    Details
    ISSN: 0743-4634
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.cb.10.110194.001343
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    A lownoise 665 GHz SIS quasi-particle waveguide receiver (1994)
    Springer
    International journal of infrared and millimeter waves 15 (1994), S. 477-492 
    Details
    ISSN: 1572-9559
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We report recent results on a 565–690 GHz SIS heterodyne receiver employing a 0.36µm2 Nb/AlO x /Nb SIS tunnel junction with high quality circular non-contacting backshort and E-plane tuners in a full height waveguide mount. No resonant tuning structures have been incorporated in the junction design at this time, even though such structures are expected to help the performance of the receiver. The receiver operates to at least the gap frequency of Niobium, ≈ 680 GHz. Typical receiver noise temperatures from 565–690 GHz range from 160K to 230K with a best value of 185K DSB at 648 GHz. With the mixer cooled from 4.3K to 2K the measured receiver noise temperatures decreased by approximately 15%, giving roughly 180K DSB from 660 to 680 GHz. The receiver has a full 1 GHz IF passband and has been successfully installed at the Caltech Submillimeter Observatory in Hawaii.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02096231
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Stress-strain analysis of geogrid-supported liners over subsurface cavities (1994)
    Springer
    Geotechnical and geological engineering 12 (1994), S. 65-86 
    Details
    ISSN: 1573-1529
    Keywords: Arching ; cavity ; finite element ; geogrids ; liners ; reinforcement ; soil ; strain ; stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Summary Finite element analyses were conducted to investigate the magnitude of tensile strains imposed on landfill liners due to the formation of subsurface cavities. The study incorporated the significance of using geogrids to reduce the magnitude of strains and possibly the potential for collapse of landfill liners. Variations of key parameters included depth of overburden (D) and diameter of the cavity (B). Estimated stress distributions were compared to theoretical values obtained from a model reported in the literature. Results indicated that, contrary to conventional wisdom, the critical area based on the mechanics of arching was above the edge of the cavity where stress concentration occurred. Incorporation of geogrid reinforcement reduced the magnitude of tensile strains. The tensile force in the geogrid was dependent upon the size of the cavity, the depth of the overburden, and the applied pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429767
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    Paper (German National Licenses)
    Fulltext
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