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Creatol (5-hydroxycreatinine), a new toxin candidate in uremic patients (1990)

Nakamura, K. ; Ienaga, K.

Springer

Cellular and molecular life sciences 46 (1990), S. 470-472

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ISSN: 1420-9071

Keywords: Creatinine ; 5-hydroxycreatinine ; creatol ; 5-hydroxy-1-methylhydantoin ; uremic toxin ; uremia

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Both 5-hydroxy-1-methylhydantoin (3) and the hitherto unrecognized 5-hydroxycreatinine (2-amino-5-hydroxy-1-methyl-imidazol-4(5H)-one or creatol) (6) can be isolated from the urine of uremic patients, in whom these compounds probably arise as oxidative metabolites of creatinine (1). The enhanced production of the well-known uremic toxin, methylguanidine (8), from creatinine (1) in such patients, almost certainly occurs via the newly recognized metabolite (6).

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01954234

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