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  • 1
    ISSN: 1432-1076
    Keywords: Hypergalactosaemia ; Portal-hepatic venous shunt ; Hepatic arterio-venous shunt ; Portosystemic shunting ; Newborn screening
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hypergalactosaemia was discovered in a newborn girl during routine metabolic screening. Hereditary enzyme deficiency was ruled out. She had multiple hepatic haemangiomas with portal-hepatic venous and hepatic arterio-venous shunts. Since she showed signs of high-output heart failure due to the arterio-venous shunt, hepatic artery embolization was performed at age 3 months. A galactose tolerance test was performed before and after embolization and when the haemangioma no longer appeared on ultrasonography. Even after embolization, the level of blood galactose was abnormally elevated in the galactose tolerance test, but the blood galactose was eliminated more rapidly than before embolization. When the hepatic haemangioma was no longer detected by ultrasonography, the peak galactose level decreased. We surmise that the hypergalactosaemia was due to these shunts. In cases of hypergalactosaemia of unknown cause; liver haemangioma with portal-hepatic venous shunting should be considered as a possible cause. If a hepatic arteriovenous shunt also exists, this may contribute to the effect of the portosystemic shunting.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 152 (1993), S. 852-855 
    ISSN: 1432-1076
    Keywords: Vitamin K status ; Faecal flora ; Breast feeding ; Formula feeding ; Infant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Faecal vitamin K1 (VK1, phylloquinone) and vitamin K2 (menaquinone, MK) concentrations were measured in 12 breast fed and 9 formula fed 1-month-old infants. Faecal concentrations of VK1 and MK-5 to-9 were significantly higher in the formula fed than in the breast fed infants. There was also a tendency for higher total faecal MK (4–10) concentrations in the formula fed [geometric mean (95% confidence intervals); 8995.0 (3872.6, 20893.0) pmol/g of dry faeces] than in the breast fed infants [2937.7 (1285.3, 6714.3),P=0.051]. The numbers of streptococci andEscherichia coli were 100 and 10 times higher, respectively, in the faeces of the formula fed than in those of the breast fed infants. Faecal concentrations of MK-6,-7 and-8, and MK-8 were correlated with the numbers of streptococci andE. coli in the faeces, respectively. Serum VK1 and MK concentrations were measured in 9 out of 12 breast fed and eight out of nine formula fed infants. The serum VK1 concentration was much higher in the formula fed infants [average (95% CI); 2.20 (1.48, 2.92) pmol/ml] than in the breast fed ones [0.30 (−0.10, 0.70),P=0.000], but MKs were not detected in the sera of most of the formula fed infants.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 615 (1991), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 76 (1994), S. 2621-2626 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Based on two different experiments and an optical field calculation, we show that the free-carrier absorption αfc in Zn(Cd)Se/ZnMgSSe semiconductor lasers is about 4 cm−1 and that it is smaller than that of GaAs/AlGaAs semiconductor lasers. We have measured the dependence of the L-I characteristics on the cavity length of double heterostructure (DH) lasers under photopumped operation and of single quantum well-separate confinement heterostructure (SQW-SCH) lasers under current-injected operation. For the DH laser, the total absorption coefficient αi and β×J0 product (β is a gain constant, and J0 is the nominal current density that makes the gain equal to zero) are estimated to be 4.2 cm−1 and 8.6×10 cm−1, respectively. For the SQW-SCH laser, αi, β, and J0 are estimated to be 21 cm−1, 4.23×10−3 cm×μm/A, and 1.9×10−3 A/(cm2×μm), respectively. By calculating the optical fields of these lasers, we have estimated that the absorption in a GaAs substrate is 16.53 cm−1 in the SQW-SCH laser and that it is negligible in the DH laser. We have shown that the large loss in the SQW-SCH laser is caused by both αfc and the absorption in the substrate and that αi in the DH laser is caused only by free carrier absorption.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 3 (1991), S. 0 
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Intracellular recordings and current and single-electrode voltage-clamp techniques were used to study the membrane responses of CA1 pyramidal neurons to bath application of L-homocysteic acid (L-HC) in the rat hippocampal slice preparation. In control artificial cerebrospinal fluid (ACSF), L-HC (25 - 250 μM) depolarized the membrane and induced a burst-like firing pattern. Both the membrane depolarization and the burst firing were blocked by the N-methyl-D-aspartic acid (NMDA) receptor antagonists D-(-)-2-amino-5-phosphonovaleric acid (AP-5, 50 μM), D-(-)-2-amino-7-phosphonoheptanoic acid (AP-7, 50 μM) and (±)-3-(2-carboxy-pipera-zin-4-yl)-propyl-1-phosphonic acid (CPP, 20 μM). In ACSF containing tetrodotoxin (1 μM), L-HC (100–300 μM) induced at resting membrane potential a depolarization which was associated with a small increase in input conductance. These effects were unaffected by 6-cyano-7-nitroquinoxaline-2, 3-dione (CNQX, 10–20 μM) but were fully blocked by AP-5, AP-7 (50 μM) and CPP (10–20 μM). In voltage-clamp experiments, L-HC induced slow inward currents which were voltage-dependent between - 70 and - 30 mV and reversed polarity near 0 mV. The L-HC-induced inward current was unaffected by CNQX (10–20 μM) but was strongly reduced by AP-5 or AP-7 (50 μM). The L-HC-induced inward current was temperature-dependent. Between -60 and -70 mV, its amplitude increased by 320% when the temperature was lowered from 33 to 22°C. The L-HC-induced current was also potentiated by the specific L-HC uptake blocker β-p-chlorophenylglutamate (Chlorpheg, 0.5–2 mM). These data suggest that L-HC preferentially activates NMDA receptors in CA1 hippocampal neurons.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 49 (1993), S. 604-607 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 48 (1992), S. 1499-1500 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 49 (1993), S. 1230-1232 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 50 (1994), S. 139-141 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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