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  • 1990-1994  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Investigation by scintigraphic methods of neutrophil kinetics under normal and septic shock conditions in the experimental baboon model (1990)
    Springer
    European journal of nuclear medicine 16 (1990), S. 643-647 
    Details
    ISSN: 1619-7089
    Keywords: Labelled neutrophil kinetics ; Septic shock ; Baboon model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this study was the correlation of neutrophil kinetics with the pathogenic course of septic shock in the baboon model. Radioactively labelled neutrophils were traced in vivo in normal baboons (n= 6) and inEscherichia coli-infected baboons, which were reinjected with labelled autologous neutrophils either 2 h after the onset of theE. coli infusion (procedure A) (n= 3) or simultaneously with the infusion (procedure B) (n=3). Cell isolation was done according to a method developed in this laboratory. The cells were labelled with tropolonate In 111. resuspended in 1–2 ml plasma and reinjected. One-minute images were taken every 5th min and then hourly for 4 h with a gamma camera and analysed with a data processor. Time-activity curves were obtained for neutrophil washout from the lungs and neutrophil accumulation in the liver and spleen. These curves were compared for normal baboons and for those treated according to procedures A and B. A significant retention of neutrophils in the lungs of baboons withE. coli-induced septic shock was noted as well as an abnormally slow rate of accumulation in the liver and spleen. It also seems that any lung injury which could be attributed to changes in neutrophil behaviour should be traced back to events during the early exposure of neutrophils to bacterial infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00998163
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Glycoprotein E of pseudorabies virus and homologous proteins in otheralphaherpesvirinae (1994)
    Springer
    Archives of virology 137 (1994), S. 209-228 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This paper reviews biological properties of glycoprotein E (gE) of pseudorabies virus (Aujeszky's disease virus) and homologous proteins in otheralphaherpesvirinae. It focuses on the gene encoding gE, conserved regions in the gE protein and its homologs, the complex of gE and gI, biological functions of gE in vitro and in vivo, the role of gE in latency and the role of gE in the induction of humoral and cellular immune responses. Special emphasis is placed on the use of gE as a marker protein in the control and eradication of pseudorabies virus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01309470
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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