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  • 1990-1994  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    5- and 7-dicyanomethylene-1,2-ethylenedithiocycloheptatrienes (1994)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 50 (1994), S. 603-606 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270193009643
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Studies on the effectiveness of H1-+H2-antagonist combinations in preventing life-threatening anaphylactoid reactions in anaesthesia and surgery: Problems with selecting the animal model from clinical data and with “equi-effective” doses (1992)
    Springer
    Inflammation research 36 (1992), S. C231 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Animal models are necessary for studies on the effectiveness of histamine H1- + H2-receptor antagonists in preventing life-threatening anaphylactoid reactions in anaesthesia and surgery. Clinical data were presented here for the first time which showed a clear correlation between the severe haemodynamic changes (shock and death) and plasma histamine levels. A dog model was developed which best resembled the clinical situation and was remarkably successful in showing the effectiveness of the H1- + H2-antagonist combination dimetindene and cimetidine compared to dimetindene (H1) alone and to low and high-dose corticosteroids. However, this model is no longer feasible after the new German Animal Protection Law in 1986. A piglet model was developed which was handicapped from the beginning by respiratory depression induced by compound 48/80 independently of histamine release. A dose had to be chosen which mostly induced only systemic histamine release reactions (grade 2), not life-threatening reactions (grade 3) confounded by respiratory distress. In addition, basal plasma histamine levels were higher than in man by one order of magnitude. however, the advantage of the piglet model was the influence of histamine on the heart rate which is similar to that in humans. In a randomized trial, the combination of dimetindene and cimetidine was superior to that of dimetindene and ranitidine or famotidine, respectively. The problem of “equieffective” doses in this field is discussed: separate clinical trials are necessary to demonstrate the effectiveness of each combination in preventing most sufficiently life-threatening reactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01997339
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Λ polarization in12C(π −,Λ) reactions atp π=4 GeV/c (1992)
    Springer
    The European physical journal 343 (1992), S. 471-475 
    Details
    ISSN: 1434-601X
    Keywords: 24.70.+ s ; 25.80.-e
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We study theΛ formation cross sections andΛ polarizations based on the Regge pole amplitudes in theπ −+12C→Λ+X(inclusive) reactions and the exclusive kaon channel reactions atp π =4 GeV/c. We found that the experimental data of inclusive cross sections can be reproduced qualitatively well by our calculation. As for the polarization, we have the experimental data that were reported by two different groups, although they have opposite sign and different magnitudes. Our calculated results do not agree with either set of data. We show that the sign of polarization is sensitive to the outgoingΛ kinetic energy in the inclusive reactions and to the outgoing kaon angle in the exclusive kaon channel reactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01289825
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    Paper (German National Licenses)
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