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  • 1990-1994  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Effects of Pseudorabies Virus on the Neuronal Properties of PC 12 Cells (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 56 (1991), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The effect of pseudorabies virus on neuronal functions was investigated in PC12 cells. During the period investigated, choline acetyltransferase was not affected, while the acetylcholinesterase activity declined steadily starting at 12 h post infection (p.i.), reaching its minimal level of 40% of the control value at 24 h p.i. In contrast, the activity of tyrosine hydroxylase, the key enzyme in catecholamine synthesis, increased to 150% of the control level by 15 h p.i., dropping off slowly with the appearance of viral cytopathology. In parallel, the infection induced, by a process independent of the extracellular Ca2+, an increased release of dopamine at 11 h p.i., followed by noradrenaline at 20 h p.i. In the infected cells, the intracellular content of catecholamine was maintained only in the presence of a high amount of catecholamine precursors in the culture medium. Three plaque-forming units per cell was the minimal multiplicity of infection required to obtain the maximal changes in enzyme activities; higher multiplicities induced more rapidly the maximal effects on tyrosine hydroxylase and acetylcholinesterase. Inhibition of DNA synthesis did not prevent the increase in tyrosine hydroxylase activity; however, protein synthesis was required. In conclusion, infection of the PC12 cells with pseudorabies virus induced significant changes in catecholaminergic and cholinergic metabolism, indicating the ability of this virus to interfere selectively with specialized neuronal functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1991.tb02006.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The decay modes of proton drip-line nuclei with A between 42 and 47 (1992)
    Springer
    The European physical journal 344 (1992), S. 135-144 
    Details
    ISSN: 1434-601X
    Keywords: 21.10.Dr ; 23.90.+w ; 27.40.+z
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Neutron-deficient isotopes with Z=21 to 26 have been produced as projectile-like fragments of an intense58Ni GANIL beam of 69 MeV/nucleon. The nuclei selected by the upgraded LISE3 spectrometer were identified and implanted in a silicon detector telescope. The43Cr,47Fe and46Fe isotopes were identified for the first time whereas45Fe,45Mn,44Mn and42V were not observed, indicating probable instability of these nuclei against particle emission. Measurements of the half-lives of43Cr and46Mn have been performed and the analysis of their measured beta-delayed proton spectra has given, through the isobaric multiplet mass equation, an empirical estimation of their masses. Half-lives of44Cr,43V,47Fe and46Fe have also been measured. A discussion of various mass predictions for nuclei at the proton drip-line is given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01291696
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Presence of cells and fibers immunoreactive toward antibodies to different peptides or amine in the digestive tract of the snailHelix aspersa (1991)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 207 (1991), S. 185-190 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: An immunocytological study of four different parts of the gut of Helix aspersa clearly demonstrates the presence of many cells and fibers immunoreactive toward antibodies directed to vertebrate (α, β-endorphin, α, β-MSH, ACTH 1-24 and ACTH 17-39, met-enkephalin, somatostatin, insulin, glucagon, P.P., serotonin) or invertebrate (FMRF-amide) peptides.These results are evidence of the presence of different substances related to known peptides or amines in the epithelial and connective tissue cells and nerve fibers of the snail gut. Immunocytochemistry may help to elucidate the morpho-functional characteristics of the enteroendocrine cells of H. aspersa.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1052070209
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    Paper (German National Licenses)
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