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  • 1990-1994  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neuroendocrinology 6 (1994), S. 0 
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The molecular mechanisms regulating GABAA receptor activity in cultured frog melanotrophs were studied using the patch-clamp technique. In the whole-cell configuration, application of GABA evoked a dose-related increase of inward chloride currents. The ED50 value, estimated from the sigmoidal dose-response curve was 2 × 10−6 M and the Hill coefficient was 1.55. The amplitude of the GABA-induced current decayed with time. Kinetics analysis of the desensitization revealed that the time-course of the current decrement was fitted by one exponential. Graded doses of GABA or association of GABA with the benzodiazepine receptor agonist flunitrazepam accelerated the desensitization process. In contrast, the time-course of the current did not significantly vary at different holding potentials. In the outside-out configuration, GABA was found to activate channels which displayed three unitary conductance levels (8, 15 and 30 pS). The channel openings of the more frequent conductance level (30 pS) exhibited short and long lasting open states (1.2 and 28.3ms at -60mV). Altogether these data reveal that frog melanotrophs possess a single population of GABAA receptors which interconvert into a higher affinity state in the presence of benzodiazepine receptor agonists. Two GABA molecules must bind to the receptor to trigger long lasting channel openings. In addition, the activity of the GABAA receptor appears to be independent of the accumulation of intracellular chloride ions.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 94 (1994), S. 439-446 
    ISSN: 1434-6036
    Keywords: 71.25.Cx ; 61.42.+h ; 71.25.-s
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Electronic properties of a general class of one-dimensional two-tile systems are calculated exactly. The systems containing periodic crystals, generalized Fibonacci quasicrystals, generalized Thue-Morse aperiodic lattices and even other two-tile aperiodic lattices, can be divided into two different families which are constructed by the inflation rules: {A, B}→{A m11 B m12,A m21 B m22} and {A, B}→{A n11 B n12,B n21 A n22}, respectively. As typical examples, global spectra of bands and density of states in some two-tile aperiodic systems are numerically calculated. Some interesting properties are obtained.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Using the inflation-deflation symmetry, we have developed a new real-space decimation approach to study the electronic properties of one-dimensional quasiperiodic lattices. The key result is the construction of a compact renormalization group that allows simple calculation of the average Green's function and the average density of states to any degree. The Fibonacci and the generalized Fibonacci lattices are used to demonstrate the method. Numerical results for the average density of states of these lattices show a good agreement with the results obtained by other methods. This confirms the validity and the efficiency of the approach.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1434-6036
    Keywords: 63.50.+x ; 71.20.Ad ; 61.42+h
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We present an exact renormalization-group approach to study the local phonon properties of the double-atom generalized Fibonacci systems in which the masses and spring constants are all associated with the aperiodic sequences constructed by the inflation rule: {A, B}→{A n Bm, A}.n(m+1) basic transformations and 2n(n+m−1)+1 basic decimations are introduced. By applying the combinations of derived transformations and decimations, we can determine exactly the renormalized local environment, up to infinite order, of any given site in the double-atom systems. Both the single-atom and double-atom phonon models are employed, and the local density of states in several sites of some generalized Fibonacci systems are numerically calculated.
    Type of Medium: Electronic Resource
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