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  • 1
    Electronic Resource
    Electronic Resource
    Comparative bioavailability of two different rectal preparations of piroxicam in man (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 315-317 
    Details
    ISSN: 1432-1041
    Keywords: Piroxicam, NSAID ; suppository, bioavailability, pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A comparative pharmacokinetic study was performed with two types of suppository each containing 20 mg piroxicam. The bioavailability of piroxicam was studied in 24 healthy volunteers in a double blind, randomised, cross over study. No significant difference was found in the pharmacokinetic parameters [AUC(0–72 h), AUC, Cmax, t1/2β calculated from plasma concentration time curves, indicating that the two preparations were bioequivalent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02333031
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  • 2
    Electronic Resource
    Electronic Resource
    Immunogenicity of the S protein of transmissible gastroenteritis virus expressed in baculovirus (1994)
    Springer
    Archives of virology 137 (1994), S. 55-67 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven fragments of the spike (S) gene cDNA of transmissible gastroenteritis virus (TGEV), as well as the full length cDNA, were cloned and expressed in baculovirus vectors. Piglets were immunized with cells infected with the recombinant viruses. Each of the recombinants induced TGEV-specific antibodies detected in a fixed cell enzyme immunoassay. The amino terminal half of the S protein, containing all four major antigenic sites (A, B, C and D), and encoded by a 2.2 kb fragment of the S gene, induced virus neutralizing (VN) antibody titers comparable with those induced by the complete S protein. Recombinant proteins lacking the A antigenic site, or with a deletion including the putative receptor binding sites and the D antigenic site, were not capable of inducing levels of VN antibodies similar to those induced by the whole S protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01311173
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  • 3
    Electronic Resource
    Electronic Resource
    Mixing-models applied to industrial batch bioreactors (1993)
    Springer
    Bioprocess and biosystems engineering 9 (1993), S. 1-12 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Mixing models for bioreactors on the basis of the tanks-in-series concept are presented and a suitable parameter-estimation method is introduced. The Monte-Carlo-optimization procedure with the inhomogeneity-curve included in the objective function is used. Results of the parameter optimization procedure are given for stirred-tank-bioreactors equipped with one and three Rushton turbines under aerated conditions. The model designed for the stirredtank with three Rushton turbines is capable to describe the mixing properties, while in case of the stirred-tank with one Rushton turbine the simulated radial circulation time does not correlate with the measured one.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00389534
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  • 4
    Electronic Resource
    Electronic Resource
    Aluminium dissolved from kitchen utensils (1994)
    Springer
    Bulletin of environmental contamination and toxicology 52 (1994), S. 396-399 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00197827
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  • 5
    Electronic Resource
    Electronic Resource
    In vitro activity of daptomycin-metronidazole combinations against mixed bacterial cultures: Reduced activity of metronidazole againstBacteroides species in the presence ofEnterococcus faecalis (1990)
    Springer
    European journal of clinical microbiology & infectious diseases 9 (1990), S. 287-291 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The in vitro activity of daptomycin-metronidazole combinations against mixed cultures of gram-positive facultative cocci and strains of theBacteroides fragilis group was investigated. Metronidazole did not influence the high activity of daptomycin against strains ofStaphylococcus aureus, Staphylococcus epidermidis andEnterococcus faecalis in the absence or presence of the co-culturedBacteroides strains. In contrast, theEnterococcus faecalis isolates protected the co-culturedBacteroides strains against the killing effect of metronidazole, even at a concentration four- or eightfold the MIC of metronidazole. Killing curve experiments confirmed this protective effect of different isolates ofEnterococcus faecalis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01968064
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  • 6
    Electronic Resource
    Electronic Resource
    Investigation of the sublethal effects of some petroleum refinery effluents (1994)
    Springer
    Journal of aquatic ecosystem stress and recovery 3 (1994), S. 129-137 
    Details
    ISSN: 1573-5141
    Keywords: petroleum ; refinery ; effluent ; acute toxicity ; sublethal effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In Canada, environmental regulations for protection of the biota from the adverse effects of effluents from petroleum refineries have tended to focus on acute toxicity. There is concern those effluents may have other subtle, but still deleterious, long-term effects on aquatic ecosystems. We have used a battery of toxicity tests to assess the acute toxicity, genotoxicity, and chronic toxicity of effluent samples from two Ontario refineries. The test organisms included representatives of the bacterial, algal, plant, cladoceran, and fish communities. The results of our preliminary study indicate that the effluent samples had little acute toxicity to the test organisms. There were indications of some sublethal toxicity to Ceriodaphnia dubia, Panagrellus redivivus, and Pimephales promelas. One of the effluents inhibited the growth of Selanastrum capricornutum (IC50 of 59.9%) and Lemna gibba (IC25 of 73.3%) and also caused a 15 percent reduction in the germination of Lactuca sativa seeds. The SOS-Chromotest, a commercially available test that measures the activity of a bacterial DNA repair system, detected genotoxic effects in a single effluent that had been concentrated ten fold. There was no apparent relationship between several chemical parameters and the observed sublethal effects. Further research is needed to establish whether or not the observed toxic effects are typical of effluents from Ontario refineries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00042942
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  • 7
    Electronic Resource
    Electronic Resource
    Triacylglycerol hydrolysis by lipase in a flat membrane bioreactor (1994)
    Springer
    Biotechnology techniques 8 (1994), S. 671-674 
    Details
    ISSN: 1573-6784
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Hydrolysis of olive oil into fatty acids by lipase in a flat membrane module is reported. Lipase was immobilized by adsorption onto a hydrophilic cellulose acetate membrane. Hydrolysis was carried out by circulating pure olive on the enzyme side of the membrane and water phase on the other side. Conversion reached 85 % after 50 hours reaction time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00241696
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  • 8
    Electronic Resource
    Electronic Resource
    Scale-up on basis of structured mixing models: A new concept (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 43 (1994), S. 195-206 
    Details
    ISSN: 0006-3592
    Keywords: bioprocess ; stirred tank ; structured mixing model ; scale-up ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A new scale-up concept based upon mixing models for bioreactors equipped with Rushton turbines using the tanks-in-series concept is presented. The physical mixing model includes four adjustable parameters, i.e., radial and axial circulation time, number of ideally mixed elements in one cascade, and the volume of the ideally mixed turbine region. The values of the model parameters were adjusted with the application of a modified Monte-Carlo optimization method, which fitted the simulated response function to the experimental curve. The number of cascade elements turned out to be constant (N = 4). The model parameter radial circulation time is in good agreement with the one obtained by the pumping capacity. In case of remaining parameters a first or second order formal equation was developed, including four operational parameters (stirring and aeration intensity, scale, viscosity). This concept can be extended to several other types of bioreactors as well, and it seems to be a suitable tool to compare the bioprocess performance of different types of bioreactors. © 1994 John Wiley & Sons, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260430303
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