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  • 1
    Electronic Resource
    Electronic Resource
    An extended x-ray absorption fine structure investigation of the structure of the active site of lactoperoxidase (1993)
    s.l. : American Chemical Society
    Biochemistry 32 (1993), S. 2780-2786 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00062a007
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  • 2
    Electronic Resource
    Electronic Resource
    Modified ECR Plasma Deposition (1993)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 140-142 (Oct. 1993), p. 79-88 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/00/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.140-142.79.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    The triangular halophilic archaebacteriumHaloarcula japonica strain TR-1 (1993)
    Springer
    Cellular and molecular life sciences 49 (1993), S. 497-502 
    Details
    ISSN: 1420-9071
    Keywords: Triangular bacterium ; Haloarcula japonica ; cell division ; surface layer ; cell surface glycoprotein ; cell morphology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have isolated a predominantly triangular disc-shaped halophilic archaebacterium, strain TR-1, from a Japanese saltern soil. The taxonomical characteristics of this strain led us to propose a new speciesHaloarcula japonica. The cell division ofHa. japonica strain TR-1 was analyzed by time lapse microscopic cinematography. Cell plates were laid down asymmetrically, generating triangular or rhombic daughter cells which then separated. We have demonstrated the occurrence of a glycoprotein with an apparent molecular mass of 170 kDa on the cell surface ofHa. japonica. The release of this cell surface glycoprotein (CSG), accompanied by a morphological change (triangular to spherical), was observed after lowering the magnesium concentration in the medium. Thus, it is likely that the CSG plays an important role in maintaining the characteristic shape ofHa. japonica.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955151
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  • 4
    Electronic Resource
    Electronic Resource
    Expression of monoamine oxidase B activity in astrocytes of senile plaques (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 419-425 
    Details
    ISSN: 1432-0533
    Keywords: Monoamine oxidase-B ; Astrocyte ; Senile plaques ; Dementia of Alzheimer type
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Monoamine oxidase (MAO) histochemistry has been performed in brains from patients with dementia of Alzheimer type (DAT) and aged controls. Conspicuous MAO-positive cell clusters were frequently observed in the amygdala, hippocampus, and insular cortex in the brains of DAT. Double staining with glial fibrillary acidic protein immunohistochemistry revealed that the clusterforming MAO-positive cells were astrocytes. Using Bielschowsky's method, Congo red and thioflavin S counterstaining, this astrocytic mass was shown to be associated with senile plaques. By the enzyme inhibition experiment, MAO activity in senile plaques was revealed to be of type B. The present results clearly indicate that MAO-B activity is expressed in fibrillary astrocytes in or around senile plaques, suggesting that these astrocytes metabolize exogenous amines in senile plaques.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307697
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  • 5
    Electronic Resource
    Electronic Resource
    Occurrence of acetylcholinesterase activity closely associated with amyloid β/A4 protein is not correlated with acetylcholinesterase-positive fiber density in amygdala of Alzheimer's disease (1992)
    Springer
    Acta neuropathologica 84 (1992), S. 425-432 
    Details
    ISSN: 1432-0533
    Keywords: Acetylcholinesterase ; Senile plaque ; β/A4 protein ; Amygdala ; Alzheimer's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the possible relationship between acetylcholinesterase (AChE)-containing fiber density and senile plaque density and between AChE-positive plaques and β/A4 protein deposition, AChE histochemistry, the modified Bielschowsky's method and β/A4 protein immunohistochemistry were performed on the amygdala of Alzheimer's disease (AD) and aged control cases. Abundant AChE-positive senile plaques were found in the amygdala and related structures in AD. These AChE-positive plaques were mainly of the primitive or diffuse type. In addition to senile plaques of typical morphologies a variety of AChE-positive structures were observed in the amygdala and related regions in AD. A comparison of serial sections stained alternatively with AChE histochemistry and β/A4 protein immunohistochemistry has revealed that these AChE-positive structures with variable morphological appearances displayed β/A4 protein immunoreactivity, indicating that AChE is localized in a variety of β/A4 protein deposition including the diffuse plaque. Thus, it is suggested that AChE is present in some senile plaques at the earliest stage. However, there was no apparent correlation between the numerical density of AChE-positive fibers and senile plaque density. These findings suggest that the degeneration of cholinergic neurons is not attributed to the occurrence of AChE activity in β/A4 protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227670
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  • 6
    Electronic Resource
    Electronic Resource
    Ubiquitin-immunoreactive inclusions in anterior horn cells and hypoglossal neurons in a case with Joseph's disease (1993)
    Springer
    Acta neuropathologica 85 (1993), S. 341-344 
    Details
    ISSN: 1432-0533
    Keywords: Joseph's disease ; Ubiquitin ; Immunocytochemistry ; Anterior horn cell ; Hypoglossal nucleus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We describe a patient with progressive spastic ataxia and ophthalmoparesis. His clinical and neuropathological findings were consistent with Joseph's disease. The most characteristic neuropathological features in the present case were ubiquitin-immunoreactive filamentous or dense inclusions in spinal anterior horn cells and hypoglossal neurons, which have been considered to be a specific finding in amyotrophic lateral sclerosis (ALS). The occurrence of ubiquitin-immunoreactive inclusions suggests that such inclusions are not totally specific to ALS and could occur in occasional degenerating motor neurons without apparent ALS neuropathology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227732
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  • 7
    Electronic Resource
    Electronic Resource
    In situ hybridization of muscle mitochondrial mRNA in mitochondrial myopathies (1990)
    Springer
    Acta neuropathologica 81 (1990), S. 1-6 
    Details
    ISSN: 1432-0533
    Keywords: In situ hybridization ; Mitochondrial DNA ; Mitochondrial myopathy ; Ophthalmoplegia ; Cytochromec oxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To determine whether a mitochondrial mRNA deficiency exists in mitochondrial myopathies, muscle biopsies from a patient with chronic progressive external ophthalmoplegia (CPEO) and a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) were studied using in situ hybridization. Histochemistry and immunohistochemistry were performed along with hybridization. Hybridization reactions were widely distributed over the sarcoplasm of all muscle fibers in the patient with MELAS. In the patient with CPEO, 80% of the fibers showed a marked decrease in density of autoradiographic grains. This marked decrease corresponded to the histochemical and immunohistochemical findings of a very weak staining of cytochromec oxidase (CCO). The isotope-labeled cDNA probe used in in situ hybridization in this study complements a part of subunit I of CCO and a part of subunit II of complex I in the mitochondrial gene. Our results suggest a defect in the mRNA in this CPEO patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00662630
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  • 8
    Electronic Resource
    Electronic Resource
    Bundles of amyloid precursor protein-immunoreactive axons in human cerebrovascular white matter lesions (1994)
    Springer
    Acta neuropathologica 87 (1994), S. 450-455 
    Details
    ISSN: 1432-0533
    Keywords: Key words: Amyloid precursor protein – Chromogranin A – Synaptophysin – White matter lesions – Immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Cerebral white matter lesions commonly observed in Binswanger's disease, multi-infarct encephalopathy and elderly people are neuropathologically characterized by diffuse incomplete demyelination and considered to be ischemic in nature. Arteriolosclerosis in the white matter is a common feature in these white matter lesions. To investigate a possible alteration of the distribution of amyloid precursor protein (APP), chromogranin A (CgA) and synaptophysin (Syn) in such white matter lesions, we examined 15 cases with white matter lesions and 5 without white matter lesions. Many bundles of axons with APP-like immunoreactivity (LI) were observed particularly in mild white matter lesions. Such bundles of axons showed similar but less intense CgA-LI and Syn-LI. They appeared to occur in areas with many ameboid or ramified microglia labeled with anti-leukocyte common antigen and few astrocytes labeled with anti-glial fibrillary acidic protein. In the center of moderate or severe white matter lesions bundles of axons with APP-LI were never observed. Since APP, CgA and Syn undergo fast axonal transport, and since following ischemic insults to central nervous system microglial reaction occurs earlier than astroglial changes, our results suggest that axonal damage, which induces disturbance of fast axonal transport, can occur even in the early stage of white matter lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294171
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of nicardipine on haemodynamic response to stress in hypertension (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 265-269 
    Details
    ISSN: 1432-1041
    Keywords: Nicardipine ; Hypertension ; calcium antagonist ; mental arithmetic ; cold pressor test ; exercise test ; haemodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of the calcium antagonist nicardipine on the pressor response to mental arithmetic, cold pressor and exercise tests have been studied in fifteen patients with established mild to moderate essential hypertension. Nicardipine 20 mg p.o. showed a hypotensive effect within 60 min, associated with a fall in total peripheral resistance and an increase in heart rate. As the pressor response to each stress was not affected by nicardipine, the peak blood pressure reached during each stress was lower. Nicardipine lowers blood pressure at rest as a result of arteriolar dilatation, associated with reflex tachycardia. The pressor responsiveness to various stresses was not affected by nicardipine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00266346
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  • 10
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of SUN 1165, a new antiarrhythmic agent, in renal dysfunction (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 411-414 
    Details
    ISSN: 1432-1041
    Keywords: SUN 1165 ; renal failure ; antiarrhythmic agent ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of a new Class I antiarrhythmic agent, SUN 1165, has been studied in 32 patients with varying degrees of renal impairment following a single oral dose of 50 mg. The apparent volume of distribution at steady state was 1.48 1 · kg−1, the absorption rate constant was 2.2 h−1, and plasma protein binding was 26.8% in subjects with normal renal function. These variables were not altered with renal impairment. More than 60% of SUN 1165 given orally was excreted unchanged via the kidney, both by tubular secretion and glomerular filtration. The elimination rate constant, the apparent total body clearance and the apparent renal clearance were linearly correlated with the endogenous creatinine clearance. The half-time of elimination was 3.4 h in normal subjects and it was prolonged to 23.7 h in severe renal failure (creatinine clearance below 20 ml · min−1 · 1.48 m−2). Dosage adjustment of SUN 1165 is necessary in renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265853
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