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  • 1
    Electronic Resource
    Electronic Resource
    14-Fluorobacteriorhodopsin and other fluorinated and 14-substituted analogs. An extra, unusually red-shifted pigment formed during dark adaptation (1990)
    s.l. : American Chemical Society
    Biochemistry 29 (1990), S. 5948-5953 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00477a010
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  • 2
    Electronic Resource
    Electronic Resource
    Pancreatic cytokeratin: an antigen of pancreatic exocrine cell autoantibodies in Type 1 (insulin-dependent) diabetes mellitus (1990)
    Springer
    Diabetologia 33 (1990), S. 363-370 
    Details
    ISSN: 1432-0428
    Keywords: Pancreatic exocrine cell antibodies ; cytokeratin ; Type 1 (insulin-dependent) diabetes mellitus ; islet cell antibodies ; pancreatic exocrine cells ; pancreatic islet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Autoantibodies reacting with human pancreatic exocrine cells were investigated by immunofluorescent techniques in 107 patients with Type 1 (insulin-dependent) diabetes mellitus, 20 first-degree relatives of the Type 1 diabetic patients, 347 patients with Type 2 (non-insulin-dependent) diabetes, 34 with alcoholic pancreatitis, 26 with rheumatoid arthritis and 107 normal control subjects. Both immunoblotting analysis and double-immunostaining methods were used to characterize the antigens targeted by the pancreatic exocrine cell autoantibodies. Sera positive for human pancreatic exocrine cell cytoplasm, producing a “fine fibrillar” pattern, were found in 21% (23/107) of the Type 1 diabetic patients. The autoantibodies were present in 39% (15/38) of Type 1 diabetic patients diagnosed within 3 months, and the prevalence decreased with duration of diabetes. The antibodies were of the IgM class in 87% (13/15) of recent-onset Type 1 diabetes cases, but IgG-autoantibodies became more prevalent with increasing duration of diabetes. Three out of 347 (0.9%) Type 2 diabetic patients and 4 of 20 (20%) first-degree relatives of Type 1 diabetic patients had autoantibodies targeted against pancreatic exocrine cells. None of the patients with alcoholic pancreatitis or rheumatoid arthritis and none of the control subjects had these antibodies. Immunoblotting analysis and double-immunostaining demonstrated that the autoantibodies reacted with 40 kilodalton cytokeratin in pancreatic exocrine cell cytoplasm. The antibody was absorbed by the Triton X-100-insoluble fraction of pancreatic extract. These results indicate the presence of distinct autoantibodies to pancreatic exocrine cells in Type 1 diabetes. This suggests the provocative concept that the cytoskeletal system of pancreatic exocrine cells is involved in the pathogenetic process of Type 1 diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404641
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  • 3
    Electronic Resource
    Electronic Resource
    Synthesis and binding of [125I2]philanthotoxin-343, [125I2]philanthotoxin-343-lysine, and [125I2]philanthotoxin-343-arginine to rat brain membranes (1991)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 34 (1991), S. 2389-2394 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00112a012
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  • 4
    Electronic Resource
    Electronic Resource
    Lectin binding and expression of blood group-related antigens in carcinoma-in-situ and invasive carcinoma of urinary bladder (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 23 (1993), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To determine whether histochemical reactivities of carcinoma-in-situ of the urinary bladder differ from those of invasive transitional cell carcinoma, we tested a profile of eight different lectins and three antibodies directed against blood group-related antigens for 15 cases of carcinoma-in-situ and 26 cases of non-papillary (6 superficially and 20 deeply) invasive transitional cell carcinoma that had been diagnosed according to the histopathological criteria of the International Union against Cancer. For biotin-labelled lectins and monoclonal antibodies to mouse blood group-related antigens, the avidin–biotin peroxidase complex method was applied. Positive histochemical reactions of peanut agglutinin without neuraminidase treatment—PNA N(–)—in the 20 deeply invasive tumour cases were significantly higher than those in the 15 carcinoma-in-situ cases (P〈0.05). In contrast, the reactions of blood group-related antigens in the 20 deeply invasive tumour cases were significantly lower than those in the 15 carcinoma-in-situ cases or the 11 normal controls (P〈0.05). The results confirm previously reported studies of the staining of PNA N(–) and blood group-related antigens on carcinoma-in-situ and invasive tumours of urothelial organs. The application of lectins and blood group-related antigens to the histopathology of urinary bladder cancer may be helpful in the differential diagnosis of carcinoma-in-situ from invasive cancer, but neither PNA N(–) nor blood group-related antigens can be solely reliable in this.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1993.tb00473.x
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  • 5
    Electronic Resource
    Electronic Resource
    Influence of excess N on FeZrN soft magnetic film : The 5th Joint MMM−Intermag Conference (1991)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 70 (1991), S. 6244-6246 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The soft magnetic properties of the FeZrN ternary system were studied in association with excess nitrogen (N) in films. The proportion of excess N (EN) is defined (z−y)/[x+(z−y)]×100 for the film composition expressed FexZryNz. This is because the advent of soft magnetism, in this system, is assumed to be due to suppression of grain growth of α-Fe by ZrN precipitated in grain boundaries, thus causing a "nanocrystalline effect.'' This means that N exceeding the amount of Zr is considered "excess.'' This paper presents the influence of excess N on soft magnetic properties, and the following conclusion was obtained. Excess N first formed a supersaturated solid solution with Fe, and acted as the origin of induced magnetic anisotropy. Supersaturated N easily moved in Fe and the orientation of easy axis was reversibly changed by re-annealing at 150 °C in a magnetic field perpendicular to the easy axis. When N was in excess, some part of excess N formed Fe4N. Fe4N caused a dispersion of the microscopic anisotropy, and lowered the permeability of the macroscopic hard axis. Both supersaturated N and Fe4N increased magnetostriction constants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.350009
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  • 6
    Electronic Resource
    Electronic Resource
    Formation of iodinated nickel phthalocyanine thin films by double-source evaporation of iodine and nickel phthalocyanine (1991)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 69 (1991), S. 3402-3403 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Thin films of iodinated nickel phthalocyanine were made by double-source evaporation of nickel phthalocyanine and iodine in vacuum. They were obtained by keeping the substrate temperature at about −90 °C. The c axes of crystallites composing the film were almost perpendicular to the quartz glass substrate. The conductivities of the films were 0.1–1 S/cm at room temperature which decreased slightly as the measuring temperature was lowered to −170 °C.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.348521
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  • 7
    Electronic Resource
    Electronic Resource
    Extremely-low-threshold and high-temperature operation in a photopumped ZnSe/ZnSSe blue laser (1991)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 59 (1991), S. 1401-1403 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A ZnSe/ZnSSe blue semiconductor laser was demonstrated to show very low threshold by direct photopumping of the ZnSe active layer. The lowest threshold at the excitation wavelength of 445 nm was 10 kW/cm2 at 300 K which is equivalent to the current density of 3.6 kA/cm2. This is the lowest threshold ever reported in II-VI photopumped lasers and is approaching the theoretically calculated threshold. The characteristic temperature of the threshold, which characterizes the temperature dependence of the threshold in the exponential form, was 124 K up to the measured 400 K and was comparable to III-V double-heterostructure lasers. The differential quantum efficiency remained the similar level up to 400 K and its decrease observed at 400 K was within 23% of the efficiency at 300 K.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.105319
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  • 8
    Electronic Resource
    Electronic Resource
    Process of formation of bone-like apatite layer on silica gel (1993)
    Springer
    Journal of materials science 4 (1993), S. 127-131 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: It has been proposed that a hydrated silica plays an important role in forming a biologically active apatite layer on the surfaces of bioactive glasses and glass-ceramics in the body. Recent experiments have shown that a silica hydrogel actually induces apatite formation on its surface in a simulated body fluid (SBF). In the present study the process of apatite formation on silica gel was investigated by means of thin-film X-ray diffraction, Fourier-transformed infrared reflection spectroscopy and scanning electron microscopic observation of the surface of the silica gel, as well as the measurement of changes in the ion concentration of the fluid. It was found that the induction period for the apatite nucleation on the surface of the silica gel was about 6 days. Once the apatite nuclei were formed they grew, taking a spherulitic form by consuming the calcium and phosphate ions from the surrounding fluid. Each spherulite consisted of a lot of flake that clustered into a petal-like morphology. The flake was carbonate-containing hydroxyapatite of small-crystallites and/or defective structure. The Ca/P ratio of the apatite was estimated as 1.5–1.6. Thus, the apatite formed was able to induce secondary nucleation of the apatite.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00120381
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  • 9
    Electronic Resource
    Electronic Resource
    In vivo incorporation of14C-phenylalanine into ascidian tunichrome (1992)
    Springer
    Cellular and molecular life sciences 48 (1992), S. 367-371 
    Details
    ISSN: 1420-9071
    Keywords: Tunichrome ; phenylalanine ; ascidian ; tunicates ; blood pigments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Ascidia ceratodes exposed to14C-phenylalanine in the surrounding seawater incorporates the radiolabel into newly biosynthesized tunichrome molecules. Radioactivity can be detected in tunichrome extracted from circulating blood cells within one day following initial exposure to the radiolabel; weak activity (≤4 μCi/mol tunichrome=22 nmol phenylalanine/mol tunichrome) is detected in 1 to 10 days; significantly higher amounts of radiolabel (57 μCi/mol tunichrome=318 nmol phenylalanine/mol tunichrome) appear 20 days after seawater exposure. Therefore, phenylalanine can function as a precursor in the biosynthesis of tunichrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01923431
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  • 10
    Electronic Resource
    Electronic Resource
    Partial purification of an endogenous elicitor from suspension-cultured cells of red bean,Vigna angularis (1992)
    Springer
    Cellular and molecular life sciences 48 (1992), S. 683-687 
    Details
    ISSN: 1420-9071
    Keywords: Suspension cells ; Vigna angularis ; UV irradiation ; endogenous elicitor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Brief irradiation with a germicidal UV lamp of cells of red bean,Vigna angularis, cultured in suspension in a quartz flask caused the release into the culture medium of an endogenous substance with elicitor activity, as well as the accumulation of isoflavone glucoside stress metabolites in the cells. The active compound was fractionated using phenylalanine ammonia lyase (PAL)-inducing activity in fresh cells as a marker. The elicitor active principle appears to be a low molecular weight (〈2000 MW) water-soluble acidic oligosaccharide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02118319
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