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Immunocytochemical localization of endothelin in cultured bovine endothelial cells (1990)

Nakamura, S. ; Naruse, M. ; Naruse, K. ; [et al.]

Springer

Histochemistry and cell biology 94 (1990), S. 475-477

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ISSN: 1432-119X

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary To investigate the intracellular localization of endothelin in cultured endothelial cells, an immunocytochemical study was carried out by the post-embedding protein A-gold technique with endothelin-specific antiserum. Gold particles were seen on the rough endoplasmic reticulum, the Golgi cisternae, the Golgi vesicles, small vesicles beneath the cell membrane, and the lysosomes. By contrast, no secretory granules were observed. These results suggest that endothelin is secreted by a constitutive pathway and that the lysosome may play an important role in regulating the biological activity of endothelin.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00272609

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