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  • 1
    Electronic Resource
    Electronic Resource
    Human pancreatic Beta-cell glucokinase: cDNA sequence and localization of the polymorphic gene to chromosome 7, band p 13 (1992)
    Springer
    Diabetologia 35 (1992), S. 743-747 
    Details
    ISSN: 1432-0428
    Keywords: Glucokinase ; polymerase chain reaction ; micro satellite DNA polymorphism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The glucose phosphorylating enzyme glucokinase plays an important role in the regulation of glucose homeostasis. Studies in rodents indicate that pancreatic Beta cells and hepatocytes express different isoforms of this protein as a consequence of the presence of tissue-specific promoters and exon 1 sequences which are spliced to a shared group of nine exons which encode most of the mRNA and protein. Here, we report the isolation and characterization of cDNA clones encoding human Beta-cell glucokinase. The sequence of human Beta-cell glucokinase shows 97% amino acid identity with that of the cognate rat protein. We also mapped the human glucokinase gene to the short arm of chromosome 7 by analysing its segregation in a panel of reduced human mouse somatic cell hybrids. In situ hybridization to metaphase chromosomes confirmed the localization of the human glucokinase gene to chromosome 7 and indicated that it was in band p 13. A microsatellite DNA polymorphism that can be typed using the polymerase chain reaction was identified upstream of exon 1 a, the Beta-cell specific first exon. The glucokinase cDNA clone and highly informative DNA polymorphism will be useful for examining the role of this gene in the pathogenesis of diabetes mellitus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429094
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Neuroradiological examination of thoracic radiculo-myelopathy due to ossification of the ligamentum flavum (1990)
    Springer
    Neuroradiology 32 (1990), S. 38-42 
    Details
    ISSN: 1432-1920
    Keywords: Spinal cord compression ; Computed tomography ; Magnetic resonance imaging ; Ossification of ligamentum flavum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sixteen cases of thoracic radiculomyelopathy due to ossification of the ligamentum flavum (OLF) were analyzed. The patients ranged in age from 39 to 78 years (average 57 years). There were 13 men and 3 women. A significant predilection of OLF for the lower thoracic spine (T9/10, T10/11, T11/12) was noticed. Plain X-ray of the thoracic spine and multidirectional tomography could give important information about the site of ossification. Computed tomography with the intrathecal injection of the water-soluble contrast material clearly demonstrated the ossification and the degree of compression of the spinal cord. The disadvantages of using computed tomography for diagnosing OLF included the necessity for the scan level to be previously decided by other methods because computed tomography of the entire spine was impractical. Magnetic resonance imaging was performed in 14 patients and gave important information about OLF and the compression of the spinal cord. The combination of MRI and computed tomography seems the most useful for the precise diagnosis of OLF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593939
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Transvenous embolization of dural caroticocavernous fistulae: technical considerations (1993)
    Springer
    Neuroradiology 35 (1993), S. 475-479 
    Details
    ISSN: 1432-1920
    Keywords: Dural arteriovenous fistula ; Cavernous sinus ; Transvenous embolization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sixteen patients with symptomatic dural caroticocavernous fistulae were treated by transvenous embolization, via the jugular vein and inferior petrosal sinus. The fistula was occuladed by thrombogenic coils. Complete resolution of symptoms and signs was achieved in 14 patients, and complete angiographic resolution was also obtained in 14 patients. Failures to achieve angiographic cure were attributed to failure to reach the fistula within the cavernous sinus precisely. Factors which make placement of the catheter at the fistula difficult are trabeculae within the cavernous sinus, a specific configuration of the superior ophthalmic vein and venous thrombosis. To improve the efficacy of tranvenous embolization, every possible venous route to the cavernous sinus therefore should be tried, to facilitate reaching the fistula and the possibility of transvenous embolization should not be thwarted by venous thrombosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00602836
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  • 4
    Electronic Resource
    Electronic Resource
    Comparative immunohistochemistry of malignant fibrous histiocytoma and sarcomatoid carcinoma of the urinary tract (1991)
    Springer
    Urological research 19 (1991), S. 69-72 
    Details
    ISSN: 1434-0879
    Keywords: Malignant fibrous histiocytoma ; Sarcomatoid carcinoma ; Urinary tract ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An immunohistochemical analysis using antibodies to cytokeratin, epithelial membrane antigen, alpha-1-antitrypsin, alpha-1-antichymotrypsin and factor XIIIa was performed in four cases of malignant fibrous histiocytoma and five cases of sarcomatoid carcinoma in the urinary tract. All cases of malignant fibrous histiocytoma showed positive staining for factor XIIIa, alpha-1-antitrypsin and alpha-1-antichymotrypsin. No case was positive for factor XIIIa, but one case with sarcomatoid carcinoma stained positive for alpha-1-antitrypsin and alpha-1-antichymotrypsin. All cases showed positive staining for cytokeratin and 4 cases with sarcomatoid carcinoma were positive for epithelial membrane antigen, but no cases with malignant fibrous histiocytoma were positive. Immunohistochemical analysis would thus help to distinguish malignant fibrous histiocytoma from sarcomatoid carcinoma of the urinary tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294025
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  • 5
    Electronic Resource
    Electronic Resource
    Synthesis and properties of new polyimides containing flourinated alkoxy side chains (1990)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 28 (1990), S. 323-331 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A series of new polyimides containing fluorinated alkoxy side chains are prepared from novel fluorinated alkoxy diamines. The dieletric constant at 1 kHz in the fluorinated polyimides decreases from 3.3 to 2.6 as fluorine content increases. The refractive index also changes from 1.58 to 1.48, dependent on the fluorine content. In addition, the fluorinated polyimides exhibit lower water absorption than the reference polyimides prepared from m-phenylenediamine.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1990.080280208
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    Paper (German National Licenses)
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