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  • 1990-1994  (1)
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  • 1990-1994  (1)
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  • 1
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The long-term (1- and 2-year) adverse tissue responses including tumor formation by subcutaneous implanation of polyurethanes (PUS) and silicone (Sil) films intorats were compared. The weight-averaged molecular weights (Mw) of the PUS prepared from 4,4′-diphenylmethanediisocyanate, poly (tetramethyleneglycol) of M, = 1000 and 1,4-butanediol are 220,000 (U-4), 124,000 (U-6), and 55,600 (U-8). The 50:50 mixed film of U-6 and silicone (U-b/sil) was prepared by rollmixing of the noncured silicone and the U-6 solution followed by evaporation of the solvent and heat-curing at 70°C. The tissue responses around implants were classified into four groups as follows: (A) tumor, (B) atypical cell proliferation accompanied by preneoplastic changes, (C) cell proliferation without preneoplastic changes, (D) no obvious responses. In both implantation periods, the PUS gave higher incidents of the adverse responses including tumor formation in comparison to Sil. No significant molecular weightdependent trend was found in a 1-year study using U-4, 6, and 8. Significant PU-dose-dependent trends were found in a 2-year study: the total active incidence (A + B + C), U-6(22/29) 〉 U-6/si1(11/29) 〉 sil(7/28); tumor incidence (A), U-6(11/29) 〉 U-6/si1(2/29) = si1(2/28). No detectable amounts of 4,4′-methylenedianiline (MDA) were found in the PUS. The methanol extracts from the PUS were negative in the mutagenicity tests. These indicate no relationship between the tumor formation by the PU films and the mutagenicities of the chemicals (mainly oligomers) leached from the PUs.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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