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  • 1
    Electronic Resource
    Electronic Resource
    Platelet-activating factor (PAF) and the development of chronic subdural haematoma (1994)
    Springer
    Acta neurochirurgica 129 (1994), S. 20-25 
    Details
    ISSN: 0942-0940
    Keywords: Chronic subdural haematoma ; histochemistry ; PAF-acetylhydrolase ; platelet-activating factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Platelet activating factor (PAF) content and PAF-acetylhydrolase (PAFAH) activity were measured in the plasma and haematoma of 34 chronic subdural haematoma (CSH) patients. The plasma PAF level in patients with CSH was higher than that in healthy controls. Although there was no correlation between the plasma PAF levels and the interval between the onset of symptoms and the day of sampling, namely, the interval after bleeding, the haematoma PAF level gradually decreased according to the interval after the onset of symptoms. There was no difference between plasma PAFAH activity in patients with CSH and that in healthy controls, and haematoma enzyme activity gradually increased correlated with the interval between the onset of symptoms and surgery. In addition, the localization of PAF in haematoma capsules was histochemically determined. PAF was solely localized to the peri-sinusoidal vessels in the outer membrane of haematoma capsules. Based on these biochemical and histochemical studies, we speculated that PAF may play a role in the development of chronic subdural haematomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400868
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Characterization of carbon material as a scanning tunneling microscopy tip for in situ electrochemical studies (1994)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 65 (1994), S. 404-406 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We have studied the feasibility of using carbon as a scanning tunneling microscopy tip material for experiments conducted under electrochemical environments. The tips were found to be stable and durable in acidic or alkaline solution for several hours. The fabricated carbon tips were capable of resolving graphite atoms in electrolyte solution under potentiostatic condition as well as in air.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1145146
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Competitive and noncompetitive N-methyl-D-aspartate antagonists protect dopaminergic and serotonergic neurotoxicity produced by methamphetamine in various brain regions (1993)
    Springer
    Journal of neural transmission 92 (1993), S. 97-106 
    Details
    ISSN: 1435-1463
    Keywords: Methamphetamine ; neurotoxicity ; N-methyl-D-aspartate ; dopamine ; serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Protective effects of NMDA antagonists on dopaminergic and serotonergic neurotoxicity produced by methamphetamine (MA) were examined. Four injections of MA (7.5 mg/kg, s.c., at 2 h intervals) caused significant decrements (40–60% of control values) in levels of dopamine (DA) and its metabolites in the rat striatum and levels of serotonin (5-HT) and its metabolite in the medial prefrontal cortex, nucleus accumbens, striatum, anterior hypothalamus, amygdala and hippocampus. These decreases in DA, 5-HT and their metabolites were prevented by pretreatment with MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist, or D-CPP-ene (SDZ EAA 494), a competitive NMDA antagonist. The results suggest that NMDA receptors play a role for MA-induced serotonergic damage in various brain regions as well as dopaminergic damage in the striatum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244869
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    Paper (German National Licenses)
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