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Morphological changes associated with growth inhibition of Trichophyton mentagrophytes by amorolfine (1992)

NISHIYAMA, Y. ; ASAGI, Y. ; HIRATANI, T. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Clinical and experimental dermatology 17 (1992), S. 0

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ISSN: 1365-2230

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Amorolfine inhibited the in-vitro growth of Trichophyton mentagrophytes to some extent at a low drug concentration of 0·8 ng/ml. Corresponding to the growth inhibition, SEM studies revealed a slight modification of hyphal morphology, i.e. a waving of the hyphal surface. These morphological alterations were more extensive with increases in drug concentration and treatment period: collapsed and distorted hyphae and exfoliation of the surface of T. mentagrophytes occurred at 8 ng/ml and marked deformation and disruption of the hyphal structure at 80 ng/ml of amorolfine. TEM revealed thickening of the cell walls and the accumulation of electron-dense granular structures in both the wall and cytoplasm in thin-sectioned cells pretreated with 8 ng/ml or more of amorolfine, although the nuclear and mitochondrial architecture was not noticeably influenced. Cytoplasmic membranes and other membranous structures of organelles such as nuclei and mitochondria were disrupted or fused, thereby losing their essential physiological activity in hyphal cells pretreated with 80 ng/ml of amorolfine. The ultrastructural study thus supports the observation that morphological changes of T. mentagrophytes caused by amorolfine were associated with its growth-inhibitory and killing activity, which depended on the drug concentration and treatment time.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2230.1992.tb00271.x

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Plasma-induced nitrogen chemisorption on a ruthenium black catalyst: formation of NH3 by hydrogenation of the chemisorbed nitrogen (1992)

Kunimori, K. ; Osumi, M. ; Kameoka, S. ; [et al.]

Springer

Catalysis letters 16 (1992), S. 443-446

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ISSN: 1572-879X

Keywords: Plasma-induced chemisorption ; nitrogen chemisorption ; Ru black catalyst ; production of ammonia ; the reactivity of chemisorbed nitrogen

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract Nitrogen was chemisorbed on a ruthenium black catalyst by a plasma discharge of N2. Temperature-programmed desorption of nitrogen showed a broad peak at around 300 °C which showed a dependence on the duration and the wattage of the discharge. The chemisorbed nitrogen species was reacted with hydrogen to form NH3 even at room temperature.