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  • 1
    ISSN: 1432-0428
    Keywords: Type 2 (non-insulin-dependent) diabetes mellitus ; renal haemodynamics ; improved glycaemic control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The impact of improved glycaemic control on renal function in newly-presenting Type 2 (non-insulin-dependent) diabetic patients has not been adequately researched. Consequently, glomerular filtration rate and effective renal plasma flow and urinary albumin excretion rates were determined in 76 subjects (age (mean (SD)): 54 (9.5) years; 50 male) of an original cohort of 110 newly-presenting normotensive non-proteinuric Type 2 diabetic patients following 6 months treatment with diet alone (n=42) or with oral hypoglycaemic agents (n=34). Significant reductions were observed in (presentation vs 6 months): body mass index (p〈0.01); fasting plasma glucose (p〈0.001); glycated haemoglobin (HbA1) (p〈0.001); systolic blood pressure (p〈0.01); and diastolic blood pressure (p〈0.001). Glomerular filtration rate declined from 117 (22) to 112 (21) ml·min−1 (p〈0.01), with unchanged effective renal plasma flow (534 (123) vs 523 (113) ml·min−1) and filtration fraction (22.4 (3.0) vs 21.8 (3.4)%). Albumin excretion rate (median (range)) declined from 1.1 (0.1–34.7) to 0.5 (0.1–29.9) μg·min−1 (p〈0.01). Changes in glomerular filtration rate (Δ values) were inversely correlated with presentation values (p〈0.001), and positive relationships were observed with Δ effective renal plasma flow (p〈0.01), and Δ glycated haemoglobin (p〈0.05). Type 2 diabetic patients with glomerular filtration rate values at presentation over 120 ml·min−1 demonstrated significant reduction in glomerular filtration rate (n=31; p〈0.001), whilst those with original values less than 120 ml·min−1 remained unchanged (n=45). Glomerular filtration rate, effective renal plasma flow and filtration fraction for the Type 2 diabetic patients remained elevated compared with age-controlled normal subjects (p〈0.01-0.001). Albumin excretion rate at presentation and 6 months were positively correlated with fasting plasma glucose levels (p〈0.05) but not renal haemodynamics. Thus, glomerular filtration rate and albumin excretion rate in newly-presenting Type 2 diabetic patients are influenced by metabolic control. Improved glycaemia for 6 months produces a reduction in glomerular filtration rate, mainly in the younger patients with values greater than 120 ml·min−1 at diagnosis of diabetes. Despite these changes, renal haemodynamic parameters remain elevated compared with age-matched normal subjects.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 43 (1994), S. 618-620 
    ISSN: 1432-055X
    Keywords: Schlüsselwörter: Schwierige Intubation – Fiberoptik – Führungsdraht ; Key words: Difficult airway – Fiberoptic intubation – Guidewire
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract. Securing the airway following surgery can be a problem in certain patients. Preparation, therefore, should include a plan for safe reintubation, if necessary. We report two patients with a difficult airway (recurrent thyroid carcinoma, inoperable carcinoma of the hypopharynx) who were at a high risk for intubation under general anaesthesia. In addition, one of the patients suffered from an acute abdomen and ileus. We used a guidewire placed into the trachea via a fiberscope to facilitate fiberoptic reintubation.
    Notes: Zusammenfassung. Die Sicherung der Atemwege nach Operationen im Bereich der oberen Luftwege kann bei bestimmten Patienten problematisch sein. Für eine sichere Reintubation im Bedarfsfall ist deshalb Sorge zu tragen. Berichtet wird über zwei Patienten, die wegen eines papillären Schilddrüsenkarzinomrezidivs bzw. inoperablen Hypopharynxkarzinoms erhebliche Intubationsschwierigkeiten und damit hochgradige Risikofaktoren für eine Intubation und ggf. Reintubation in Allgemeinanästhesie aufwiesen. Zusätzlich bestand bei einem Patienten eine Ileussymptomatik. Ein fiberoptisch plazierter endotrachealer Führungsdraht diente dabei als post- bzw. präoperative Reintubationshilfe.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 633 (1991), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 6 (1992), S. 0 
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Full elastolytic activity in Pseudomonas aeruginosa is a result of the combined activities of elastase, alkaline proteinase, and the lasA gene product, LasA. The results of this study demonstrate that an active fragment of the LasA protein which is isolated from the culture supernatant fraction is capable of degrading elastin in the absence of elastase, thus showing that LasA is a second elastase produced by this organism. In addition, it is shown that LasA-mediated enhancement of elastotysis results from the separate activities of LasA and elastase upon elastin. The LasA protein does not affect the secretion or activation of a proelastase as previously proposed in other studies. Furthermore, LasA has specific proteolytic capability, as demonstrated by its ability to cleave β-casein. Preliminary analysis of β-casein cleavage in the presence of various protease inhibitors suggests that LasA may be classified as a modified serine protease.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 65 (1994), S. 1237-1239 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The H− source for HERA is based on the design of that at FNAL. It was modified according to the Deutsches Elektronen-Synchrotron requirements. There is only one H− source connected to the H− LINAC. It must run for long uninterrupted periods with a low duty factor and a high reliability. The measured cesium distribution showed that it is necessary to keep the cold box as a barrier. The operation of the cold box was improved with a new type of high voltage insulator and a special protection against condensation at the feedthrough for high voltage and −30 °C freon. The bending magnet of the cold box will be further improved by using a permanent magnet instead of the electromagnet. A unit was designed that includes all the essential elements which are under vacuum. It can be replaced in minutes and contains a newly designed H2 piezovalve and a remodeled magnetron. The cathode of the magnetron can be heated. It is now possible to run at a low repetition rate of 1/4 Hz and thus reduce Cs and H2 consumption.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 65 (1994), S. 1459-1461 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: An electronic pepper pot has been developed at DESY for analyzing the H− beam. It consists of a number of slits in front of a harp with a high wire density. Multiplexing of the harp signals is done in the vacuum. The number of slits and the distance between the harp and the slits can be varied according to the beam parameters. The first version consists of a harp with 484 wires which are 0.1 mm wide with a spacing of 0.1 mm. They are printed on a board. The storage and readout is done using three chips in the vacuum. External transfer of the analog signals is done with a few lines. One may measure the current distribution and the emittance within one shot of the beam and is free to choose the time for the sample. This is of special interest for sources with a low repetition rate such as the HERA H− source. The present arrangement is only a first step. Further designs are discussed.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The components of the first 50 MeV accelerator in the chain of injectors to the 820 GeV HERA proton ring are described including the high energy transport line. An H− beam originates in the cesium loaded magnetron source, is preaccelerated by a radio frequency quadrupole to 750 keV, raised to 50 MeV energy in three rf resonators, and is analyzed in the transport line. The H− ions are converted to protons by stripping, when the beam is injected over several turns into the synchrotron DESY3.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 36 (1992), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In this study, the mechanisms underlying stimulation of T-cell proliferation by human blood dendritic cells (BDC) and their differentiation have been defined with a panel of monoclonal antibodies (MoAbs)- It was found that the MoAbs against LFA-I (CDlla), CD11c. LFA-3 (CD58), ICAM-1 (CD54) or HLA-DR could significantly suppress T-cell proliferation in an allogeneic mixed lymphocyte reaction (P〈0.05), while being unable to inhibit clustering of BDC with T cells. Addition of anti-CD18 or CD45 MoAbs increased the size of clusters after 18 h of culture, but had no effect on the proliferation of T cells (P〈0.05). The suppressive effect of the MoAbs may be viewed not as an inhibition of contact between BDC and T cells, but rather as a blocking of co-stimulatory signals for T-cell activation, which are mediated by interaction of the adhesion molecules. After depleting the BDC preparations of monocytes. we used a double staining in FACS analysis to demonstrate that BDC do not express specific T (CD3), B (CD20 and CD2l)and myeloid cell markers (CDl1b, CDl3 and CD14), but abundant class II antigens. This pattern remained unaltered after 8 days of culture in the presence of 100 U/ml GM-CSF, although a threefold increase of HLA-DQ and ICAM-1 molecules on the cultured cells was observed.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To investigate the differentiation and activation of monocytes, the combined effects of 1,25-dihydroxyvitamin D3 (D3) and IL-4 on human blood monocytes were examined with respect to expression of MHC class-II antigens, accessory activity, and phagocytic capacity. IL-4 was reported lo upregulate the expression of MHC class-II antigens and accessory activity of monocytes. The experiments described here demonstrate that D3 inhibits the expression of all three subtypes of MHC class-II antigens (HLA-DR, -DP and -DQ) as well as the accessory activity of monocytes. both in a dose- and time-dependent manner. However, D3 enhances the immunoglobulin- and complement-dependent phagocytosis by monocytes in a dose- and time-dependent manner. When monocytes are treated with both IL-4 and D3, the effects of D3 are reverted by IL-4. suggesting that IL-4 induces the development of monocytes into accessory cells, whereas D3 stimulates differentiation of monocytes into classical macrophages. These findings provide further evidence for the contention that, depending on defined stimuli, monocytes may develop either into accessory cells or into classical macrophages.
    Type of Medium: Electronic Resource
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