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  • 1
    Electronic Resource
    Electronic Resource
    Influence of body parameters on female peak bone mass and bone loss (1993)
    Springer
    Osteoporosis international 3 (1993), S. 61-66 
    Details
    ISSN: 1433-2965
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01621866
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Prognostic relevance of histological findings on bone marrow biopsy in myelodysplastic syndromes (1993)
    Springer
    Annals of hematology 66 (1993), S. 85-91 
    Details
    ISSN: 1432-0584
    Keywords: Myelodysplastic syndromes ; Bone marrow biopsy ; FAB
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bone marrow biopsy (BMB) has aroused growing interest as a possible aid in the diagnostic and prognostic evaluation of myelodysplastic syndromes (MDS). Previous reports have pointed out that MDS patients with blastic aggregates or severe bone marrow (BM) fibrosis are characterized by a worse clinical outcome. BMBs of 106 MDS patients were retrospectively reviewed, and relationships among the different histological parameters as well as clinicopathological correlations were looked for. Three patterns of BM blastic infiltration (“diffuse,” “cluster,” and “large”) were recognized. Overt leukemic transformation and overall survival were selected as prognostic end points. BM infiltration was “diffuse” in 18, “cluster” in 48, and “large” in 40 cases. RAEB-t patients accounted for about half of the “large” cases, and none had a “diffuse” pattern (p〈0.01). Nineteen patients showed extensive BM fibrosis; most of them were characterized by “cluster” blastic infiltration and megakaryocyte hyperplasia. Leukemic transformation occurred in 67% of “large” cases (p〈0.001) and in none of the “cluster” cases with severe BM fibrosis (p〈0.01); however, survival was equally poor in these two groups because of early leukemic transformation (large cases) and BM failure (cluster cases). The FAB classification did not significantly correlate with prognosis. Patients with “cluster” BM infiltration and severe fibrosis can be regarded as a true separate MDS subset characterized by unique clinicopathological and prognostic features. Because of the subacute clinical behavior of most cases, and the poor performance status of many elderly patients, there is still controversy as to the best therapeutic approach in MDS. Histological analysis allowed two groups of MDS patients to be identified, both characterized by poor life expectancy, who could benefit from early aggressive chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01695890
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  • 3
    Electronic Resource
    Electronic Resource
    Incidence and histological features of bone marrow involvement in malignant lymphomas (1992)
    Springer
    Annals of hematology 65 (1992), S. 61-65 
    Details
    ISSN: 1432-0584
    Keywords: Bone marrow biopsy ; Hodgkin's disease ; Non-Hodgkin's lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bone marrow biopsy (BMB) is a routine investigation in the diagnosis and staging of Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL), and there is evidence supporting its prognostic importance in some histological varieties. The histological characteristics of BMB in 433 NHL and 155 HD patients were reviewed for clinicopathological correlations; 36 of these cases were also studied by means of immunohistochemistry. BM infiltrates were discovered in 171 NHL patients. In 36 cases, the diagnosis of NHL was directly established by BMB; a discordance between lymph node and BM histology was observed in 38 of the other 135 cases. BM-positive centroblastic and immunoblastic NHL were significantly associated with larger infiltrates, BM fibrosis, and megakaryocytic hyperplasia. Leukemization at diagnosis was more frequent in low-malignancy NHL. No correlation was found between histology and prognosis, although immunohistochemistry revealed a B-cell phenotype in all but two cases. BMB was positive in 18 of the 155 HD patients and directly diagnostic in two; Reed-Sternberg and Hodgkin cells were CD-30 positive and surrounded by T-cell infiltration. The concordance between BM and lymph node histology was fairly satisfactory, although the relationships between BM infiltration and other histological parameters may reflect peculiar interactions with BM microenvironmental factors. The usefulness of BMB in the diagnosis of malignant lymphomas has been demonstrated, and further progress can be expected from the availability of reliable immunohistochemical markers of clonality reacting on paraffin-embedded BM sections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01698130
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  • 4
    Electronic Resource
    Electronic Resource
    Analysis of diagnostic procedure costs for cerebrovascular disease admission to a highly specialized hospital (1991)
    Springer
    Neurological sciences 12 (1991), S. 397-405 
    Details
    ISSN: 1590-3478
    Keywords: Diagnostic procedures ; teaching hospital ; hospital costs ; cerebrovascular disease ; lenght of stay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario La durata della degenza e i costi sostenuti nei ricoveri per malattie cerebrovascolari dipendono da vari fattori relativi a struttura, paziente e patologia. Al fine di evidenziare quale peso abbiano questi singoli fattori abbiamo studiato 240 pazienti ricoverati per malattie cerebrovascolari presso una divisione neurologica e due divisioni mediche di un ospedale altamente specializzato. L'analisi statistica dei dati, raccolti dalle cartelle cliniche, ha dimostrato l'effetto di vari fattori. Alcuni incrementavano solo la durata della degenza (gravi sequele neurologiche alla dimissione, ricovero in Medicina Generale, diagnosi di emorragia, ipertensione arteriosa). altri aumentavano i costi degli esami (durata della degenza, stato civile) ed i costi erano più alti nei ricoveri in reparto specialistico. La durata della degenza era invece più bassa in presenza di un numero maggiore di infermieri per letto. L'età avanzata ed il sesso maschile erano associati alla riduzione dei costi degli esami diagnostici.
    Notes: Abstract Lenght of stay and hospital costs for cerebrovascular disease admissions depend on several hospital-, patient- and disease-related factors. To determine the incidence of each of these factors we studied 240 admissions for cerebrovascular diseases in a neurology division and in two medical divisions of a highly specialized hospital. Statistical analysis of the data collected from the case records revealed the effect of several factors. Some increased only the length of stay (severe neurological sequels on discharge; stay in general medicine, diagnosis of hemorrhage, arterial hypertension). Others increased investigation costs (length of stay, marital status), and costs were higher in a specialists ward. Length of stay was shorter where the nurse/bed ratio was higher. Old age and male sex were associated with a lower cost of diagnostic procedures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02335780
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    Paper (German National Licenses)
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